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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

New research may help better understand the causes of human diseases

New University of Gloucestershire research aims to increase our understanding of the causes of human diseases, potentially leading to the design of better treatments in the future.

7 Jan 2022

Curia unveils comprehensive mRNA solution

Curia, formerly AMRI, a leading contract research, development and manufacturing organization, today unveiled its messenger RNA solution, which includes discovery, process development and mRNA drug substance production, through large-scale lipid manufacturing, lipid nanoparticle formulation and development for full-scale sterile fill-finish services.

From Curia Global, Inc. 7 Jan 2022

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

In a recently published article in the journal Nano-Micro Letters, scientists have provided an in-depth review on the application and benefits of nanotechnology in the development of coronavirus disease 2019 (COVID-19) vaccines.

7 Jan 2022

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

An experimental immunotherapy can temporarily reprogram patients' immune cells to attack a specific target via only a single injection of messenger RNA (mRNA), similar to the mRNA-based COVID-19 vaccines, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2022

Study reinforces the link between microglia and some cases of brain disease

Certain subtle differences in DNA sequences are known to raise the chances a person may develop Alzheimer's or Parkinson's disease.

6 Jan 2022

PLOS and CSHL expand partnership to offer new options for sharing preprints in medicine

The Public Library of Science (PLOS) and Cold Spring Harbor Laboratory (CSHL) today announced an expansion of their longstanding partnership to offer authors more options for rapidly and easily sharing their research before publication in a journal.

6 Jan 2022

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

Standard chemotherapies may efficiently kill cancer cells, but they also pose significant risks to healthy cells, resulting in secondary illness and a diminished quality of life for patients. To prevent the previously unavoidable damage, researchers, led by Penn State, have developed a new class of nanomaterials engineered to capture chemotherapy drugs before they interact with healthy tissue.

6 Jan 2022

Scientists discover a division of labor between genetic switches

Two X chromosomes are actually one too many. Female mammalian cells hence switch off one of them – but only when the cells start to specialize into tissues.

5 Jan 2022

Horizontal gene transfer between viruses and hosts plays a major role in driving evolution

The first comprehensive analysis of viral horizontal gene transfer (HGT) illustrates the extent to which viruses pick up genes from their hosts to hone their infection process, while at the same time hosts also co-opt useful viral genes.

5 Jan 2022

New compound could combat multidrug-resistant pathogens in healthcare settings

For years, public-health experts have been sounding the alarm about the next phase in humanity's co-existence with bacteria - a dark future where emerging strains have rendered once-powerful antibiotics useless.

5 Jan 2022

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.

5 Jan 2022

New CRISPR-based assay can non-invasively detect a biomarker of acute kidney rejection in urine

When a patient receives a kidney transplant, doctors carefully monitor them for signs of rejection in several ways, including biopsy. However, this procedure is invasive and can only detect issues at a late stage.

5 Jan 2022

New gene therapy addresses primary cellular deficit associated with limb-girdle muscular dystrophy 2B

Children's National Hospital experts developed a new pre-clinical gene therapy for a rare disorder, known as limb-girdle muscular dystrophy (LGMD) 2B, that addresses the primary cellular deficit associated with this disease.

4 Jan 2022

Unique nanoparticle can deliver genome editing technology to endothelial cells

The lab of Youyang Zhao, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls.

4 Jan 2022

Research provides compelling insights into the complex nature of genomic imprinting in mice

Mammalian offspring inherit two versions, or alleles, of each gene with one allele from each biological parent. However, gene expression is tightly regulated and certain genes undergo the phenomenon of "genomic imprinting", which is where only the allele received by the male or the female parent is expressed.

4 Jan 2022

Exposure to parasitic roundworm linked with lower lung-function and asthma in younger men

By looking at the exposure to the parasitic roundworm Ascaris lumbricoides/suum in Nothern Europe (Norway, Denmark and Estonia), the study finds that younger men exposed to Ascaris had a striking reduction in lung function and nearly five times higher odds of having asthma compared to the non-exposed.

4 Jan 2022

DNA News and Research

Further Reading

New research may help better understand the causes of human diseases

Curia unveils comprehensive mRNA solution

From laboratory to clinic - Nanotechnology-enabled mRNA COVID-19 vaccines

New approach with mRNA preparation reprograms T cells to attack heart fibroblasts

Study reinforces the link between microglia and some cases of brain disease

PLOS and CSHL expand partnership to offer new options for sharing preprints in medicine

New engineered nanomaterials help capture chemotherapy drugs to avoid tissue damage

Scientists discover a division of labor between genetic switches

Horizontal gene transfer between viruses and hosts plays a major role in driving evolution

New compound could combat multidrug-resistant pathogens in healthcare settings

Folic acid-like drug reprograms DNA methylome of aggressive brain tumors

New CRISPR-based assay can non-invasively detect a biomarker of acute kidney rejection in urine

New gene therapy addresses primary cellular deficit associated with limb-girdle muscular dystrophy 2B

Unique nanoparticle can deliver genome editing technology to endothelial cells

Research provides compelling insights into the complex nature of genomic imprinting in mice

Exposure to parasitic roundworm linked with lower lung-function and asthma in younger men

Study finds increased oxidative stress, oxidant damage and glutathione deficiency in COVID-19 patients

COVID-19 tests with the new assay may be just as reliable as laboratory-based molecular tests

Genomic variant may help predict which patients will experience chemotherapy-induced cardiotoxicity

Researchers discover how the sponginess of stem cell nuclei controls cell differentiation

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