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New study can help determine effectiveness of chemotherapy in patients with bladder cancer

In patients with bladder cancer, chemotherapy effectiveness is partially determined by the body's immune system response to the malignancy. This is the conclusion of research conducted by a team of scientists from Charité - Universitätsmedizin Berlin and the Berlin Institute of Health.

15 Jan 2021

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

It was also classified as a "Variant of Concern" (VOC B.1.1.7) in December 2020. First discovered in Kent, United Kingdom, in September 2020, this new variant has since been found in more than 29 countries across the globe, including the USA.

14 Jan 2021

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail.

14 Jan 2021

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

The unchecked advance of COVID-19 has made it a top public health priority to produce a vaccine capable of inducing a safe and powerful protective response against its causative pathogen: SARS-CoV-2. An encouraging new study shows the immunogenicity, safety, and protective efficacy, of a Newcastle disease virus (NDV)-based intranasal vector vaccine in animal studies.

14 Jan 2021

The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs

Biomedical engineers at Duke University have devised an algorithm to remove contaminated microbial genetic information from The Cancer Genome Atlas (TCGA).

13 Jan 2021

New genomics resource details the small RNA transcriptomes of four mosquito species

Researchers from Boston University School of Medicine provide a new genomics resource that details the small RNA transcriptomes (gene expression) of four bio-medically important mosquito species.

13 Jan 2021

Influenza drug enisamium a potential COVID-19 treatment

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Jan 2021

Researchers map genetic changes that may have facilitated SARS-CoV-2’s jump from bats to humans

Researchers from the University of Cambridge and the Pirbright Institute in the UK have identified key genetic changes in SARS-CoV-2 that may be responsible for the virus’s jump from bats to humans. The team also determined which animals contain cellular receptors that allow the virus to enter cells more effectively, zoning in on potential animals that acted as an intermediary host in facilitating SARS-CoV-2’s zoonosis.

13 Jan 2021

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Researchers from the University of Seville and the University of Pavia have identified a link between Amyotrophic Lateral Sclerosis (ALS) and the accumulation of DNA-RNA hybrids in the genome.

13 Jan 2021

Large study provides new understanding of genome diversity in Ukrainian population

Today, the largest study of genetic diversity in Ukraine was published in the open science journal GigaScience.

13 Jan 2021

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

A team of HIV researchers, cellular biologists, and biophysicists who banded together to support COVID-19 science determined the atomic structure of a coronavirus protein thought to help the pathogen evade and dampen response from human immune cells.

13 Jan 2021

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

13 Jan 2021

Daily circadian cycles may impact our ability to fight disease

An analysis of an exhaustive dataset on cells essential to the mammalian immune system shows that our ability to fight disease may rely more heavily on daily circadian cycles than previously assumed.

12 Jan 2021

UTSW study uncovers a gene linked to growth of breast cancer

A team of UT Southwestern researchers has identified a gene involved in the growth of breast cancer, a finding that could lead to potential new targets for treatment.

12 Jan 2021

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

A recent study conducted at the University of Malta Medical School, Malta, has revealed that a drop in the level of particulate matter 2.5 (PM2.5), which are airborne pollutant particles with a diameter of 2.5 micrometer, in the atmosphere due to lockdown is associated with the arrival of a newer variant of SARS-CoV-2, which has eventually displaced the original virus after lockdown.

12 Jan 2021

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

12 Jan 2021

Stress during pregnancy could affect the baby's chance of developing multiple diseases

Stress on an expectant mother could affect her baby's chance of developing disease - perhaps even over the course of the child's life, UC researchers have found.

12 Jan 2021

Mosaic mutations during embryonic development can cause autism spectrum disorder

Two studies in today's Nature Neuroscience, led by researchers at Boston Children's Hospital, Brigham and Women's Hospital (BWH), and Harvard Medical School (HMS), implicate mosaic mutations arising during embryonic development as a cause of autism spectrum disorder (ASD). The findings open new areas for exploring the genetics of ASD and could eventually inform diagnostic testing.

11 Jan 2021

Master Regulator proteins control cancer transcriptional identity

Thousands of different genetic mutations have been implicated in cancer, but a new analysis of almost 10,000 patients found that regardless of the cancer's origin, tumors could be stratified in only 112 subtypes and that, within each subtype, the Master Regulator proteins that control the cancer's transcriptional state were virtually identical, independent of the specific genetic mutations of each patient.

11 Jan 2021

Researchers succeed in mapping the structure of virus that causes diarrhea

Researchers at Umeå University in Sweden have for the first time at the atomic level succeeded in mapping what a virus looks like that causes diarrhea and annually kills about 50,000 children in the world.

11 Jan 2021

Genome News and Research

New study can help determine effectiveness of chemotherapy in patients with bladder cancer

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

The Cancer Microbiome Atlas gives clearer picture of microbiota living in organs

New genomics resource details the small RNA transcriptomes of four mosquito species

Influenza drug enisamium a potential COVID-19 treatment

Researchers map genetic changes that may have facilitated SARS-CoV-2’s jump from bats to humans

Researchers identify link between ALS and accumulation of DNA-RNA hybrids in the genome

Large study provides new understanding of genome diversity in Ukrainian population

Biologists reveal unusual structure of coronavirus protein linked to immune evasion

Researchers identify a simple way to eliminate sequencing errors produced by portable DNA sequencer

Daily circadian cycles may impact our ability to fight disease

UTSW study uncovers a gene linked to growth of breast cancer

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

Researchers determine the atomic structure of protein that helps coronavirus to evade immune cells

Stress during pregnancy could affect the baby's chance of developing multiple diseases

Mosaic mutations during embryonic development can cause autism spectrum disorder

Master Regulator proteins control cancer transcriptional identity

Researchers succeed in mapping the structure of virus that causes diarrhea

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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