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HPV16 reprograms immune cells to weaken cancer defenses

The most common cancer-causing strain of human papillomavirus (HPV), HPV16, undermines the body's defenses by reprogramming immune cells surrounding the tumor, according to new research from the Keck School of Medicine of USC.

19 Aug 2025

Researchers find plasma donors with broad malaria protection

Malaria, caused by Plasmodium falciparum, remains a major global health threat, claiming 600,000 lives annually, mostly young children in sub-Saharan Africa. Immunity to severe malaria develops after repeated infections and is mediated by antibodies blocking the parasite's highly diversified PfEMP1 adhesion proteins from binding to the human endothelial protein C receptor (EPCR) on blood vessel walls.

19 Aug 2025

MIT technique reveals how AI models predict protein functions

Within the past few years, models that can predict the structure or function of proteins have been widely used for a variety of biological applications, such as identifying drug targets and designing new therapeutic antibodies.

19 Aug 2025

Missing messenger RNA fragments unlock new immunotherapy targets in pediatric brain tumors

A new study, led by researchers at Children's Hospital of Philadelphia (CHOP), identified tiny pieces of messenger RNA that are missing in pediatric high-grade glioma tumors but not in normal brain tissues.

18 Aug 2025

Bacteria and viruses team up to target cancer

Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team.

18 Aug 2025

It’s almost flu season. Should you still get a shot, and will insurance cover it?

For parents of school-aged children, the fall to-do list can seem ever-growing. Buy school supplies. Fill out endless school forms.

18 Aug 2025

New therapies for acute kidney injury show promise

Acute kidney injury (AKI) is a severe renal disorder affecting approximately 10%-15% of hospitalized patients and up to 50% in intensive care units (ICUs). Its pathogenesis involves complex inflammatory regulatory mechanisms. As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in AKI development, extensively participating in inflammation, fibrosis, tissue injury repair, and remote organ damage.

18 Aug 2025

2025 Chikungunya outbreak: A global health challenge

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus causing fever, severe joint pain, rash, and muscle aches, mainly transmitted by Aedes mosquitoes. As of 2025,

From Sino Biological Inc. 18 Aug 2025

Electrophysiology-based strategies enhance cancer immunotherapy

Tumor electrophysiological abnormalities, characterized by membrane potential dysregulation, ion channel network remodeling, and microenvironmental signaling interactions, are critical drivers of malignancy.

17 Aug 2025

Stem-like peripheral helper T cells found to sustain inflammation in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on patients' lives.

17 Aug 2025

Weill Cornell Medicine leads $14.9 million effort to develop personalized HIV cures

A multi-institutional team led by Weill Cornell Medicine has received a five-year, $14.9 million grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to find ways to remove latent HIV from the cells of individuals with HIV.

17 Aug 2025

Nanobody breakthrough offers precise targeting of lung cancer cells

A research team led by Dr. Juyeon Jung at the Bio-Nano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), has developed a nanobody-based technology that can precisely identify and attack only lung cancer cells, opening new possibilities for cancer therapy.

17 Aug 2025

Genetically-engineered immune cells show promise for preventing organ rejection

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.

17 Aug 2025

Engineered CD40 antibody shrinks tumors and induces remission

Over the past 20 years, a class of cancer drugs called CD40 agonist antibodies have shown great promise-and induced great disappointment.

14 Aug 2025

Llama-derived nanobody VHH21 destroys the spike-trimer of SARS-CoV-2

Neutralizing antibodies that merely block receptor binding are losing ground against heavily mutated SARS-CoV-2 Omicron sub-variants.

14 Aug 2025

New diagnostic tool offers rapid, low-cost blood test for multiple diseases

Researchers at Arizona State University have developed a breakthrough diagnostic tool that could transform how quickly and reliably we detect illnesses like COVID-19, Ebola, AIDS or Lyme disease. The test uses just a single drop of blood, costs a couple of dollars and delivers results in only 15 minutes.

13 Aug 2025

Research finds long-term health challenges in survivors of childhood cancer

Researchers at City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States with its National Medical Center ranked among the nation's top cancer centers by U.S. News & World Report, today published a new study which found that some survivors of childhood cancer are more at risk for serious health issues as they grow older, including new cancers and chronic conditions like heart disease.

11 Aug 2025

New imaging technique reveals how antibodies reshape cancer cell receptors

A new study shows how the single-molecule organization of receptors in a cellular context determines the function of antibodies, opening up new pathways for the development of cancer immunotherapies.

11 Aug 2025

Early clinical trial supports MASL as a targeted oral cancer treatment

Rowan University and Sentrimed, a clinical-stage biopharmaceutical company focused on developing safer, orally dosed oncology therapies, today announced results from a National Cancer Institute (NCI) funded clinical trial evaluating MASL in patients with oral squamous cell carcinoma (OSCC).

8 Aug 2025

Understanding the biomarkers and mechanisms associated with anti-NMDAR encephalitis

Encephalitis is a potentially life-threatening condition that involves inflammation of the brain. While some cases of encephalitis are caused by a bacterial or viral infection, other cases of 'autoimmune' encephalitis result when the body's own immune system attacks the brain.

8 Aug 2025