Efficacy News and Research

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Study explores phytochemical-based antivirals against SARS-CoV-2 infection

A new study depicted plant-based biologically active antiviral agents that are effective against SARS-CoV-2 infection.

11 Apr 2022

Efficacy of miniaturized electrostatic precipitator respirators in removal of SARS-CoV-2 bioaerosols compared to N95 masks

Researchers developed a prototype of a miniaturized electrostatic precipitator that can be used as an apparatus to effectively remove SARS-CoV-2 containing bioaerosols.

11 Apr 2022

Study explores COVID-19 vaccine hesitancy among those with underlying medical conditions

In a recent study posted to the medRxiv* preprint server, researchers examined the coronavirus disease 2019 (COVID-19) vaccine uptake and hesitancy among people with chronic or severe health conditions.

11 Apr 2022

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

A recent study posted to the medRxiv* preprint server assessed the impact of sotrovimab treatment on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-infected immunocompromised (IC) patients.

11 Apr 2022

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers developed aminoadamantane nitrates compounds that inhibit the ion channels formed by the envelope (E) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enable targeted drug delivery of nitric oxide (NO)-related group for S-nitrosylation of host angiotensin-converting enzyme 2 (ACE2), which would inhibit ACE2 binding with the viral spike (S) protein and thereby inhibit viral replication in the host.

11 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

The effect of unsuppressed HIV on T-cell response to COVID-19

A new study evaluates the impact of HIV infection on SARS-CoV-2 T-cell responses during the first and second waves of COVID-19 in South Africa.

10 Apr 2022

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Researchers identify a potentially effective compound against COVID-19 against the SARS-CoV-2 PLpro.

10 Apr 2022

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.

10 Apr 2022

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

Natural killer (NK) cells derived from cord blood that were activated and complexed with a CD30/CD16A bispecific antibody elicited an 89 percent overall response rate in patients with relapsed or refractory CD30+ lymphoma, according to results from a phase I/II clinical trial presented at the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Patients with non-small cell lung cancer (NSCLC) treated with the KRAS G12C inhibitor sotorasib (Lumakras) had a two-year overall survival rate of 32.5 percent, according to data from the CodeBreaK 100 clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

A new chimeric antigen receptor (CAR) T-cell product had an acceptable safety profile and showed early signs of efficacy as a monotherapy and in combination with an mRNA vaccine in patients with solid tumors, according to preliminary data from a phase I/II clinical trial presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

Efficacy News and Research

Study explores phytochemical-based antivirals against SARS-CoV-2 infection

Efficacy of miniaturized electrostatic precipitator respirators in removal of SARS-CoV-2 bioaerosols compared to N95 masks

Study explores COVID-19 vaccine hesitancy among those with underlying medical conditions

New research on SARS-CoV-2 Omicron variant mutations and sotrovimab therapy

S-Nitrosylation of ACE2 inhibits binding of SARS-CoV-2 spike protein

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

The effect of unsuppressed HIV on T-cell response to COVID-19

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

NK cells complexed with bispecific antibody elicit high response rate in patients with resistant lymphomas

NSCLC patients treated with KRAS G12C inhibitor sotorasib may receive long-term clinical benefit

Preliminary data from clinical trial reveals safety, efficacy of new CAR T-cell therapy for solid tumors

Artificial intelligence model could predict side effects resulting from new combination therapies

Many clinical trials fail to account for previous or ongoing studies, researchers show

Study explores the antibody evasion pattern of SARS-CoV-2 Omicron sublineages

SARS-CoV-2 Omicron variant spike-specific unique cluster of differentiation cells

Evaluating immunogenicity after BNT162b2 booster vaccination

UC researcher awarded renewal grant to continue the study of genetic drivers of breast cancer

Efficacy of SARS-CoV-2 hyperimmune globulin in treatment of severely immunocompromised hospitalized COVID-19 patients

Study explores broad-spectrum, host-acting antiviral strategy to treat SARS-CoV-2

Industry Focus eBook - Forensics & toxicology (2nd edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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