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Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Optibrium, a leading developer of software and AI solutions for drug discovery, today launched the latest version of its drug discovery platform, StarDrop.

From Optibrium Ltd. 2 Oct 2023

Could plant-based phytonutrients be the secret weapon against obesity?

This comprehensive review in the journal Foods explores the therapeutic potential of phytonutrients in combating obesity. The paper delves into various plant-based compounds like polyphenols, alkaloids, and terpenoids, detailing their mechanisms of action in inhibiting fat accumulation, regulating metabolism, and even altering gut microbiota.

1 Oct 2023

Cancer cells hijack enhancer DNA to grow faster, study finds

University of Toronto researchers have found that cancer cells can enhance tumor growth by hijacking enhancer DNA normally used when tissues and organs are formed.

29 Sep 2023

New tau PET radiotracer shows promise for early detection of Alzheimer's disease

A new tau PET radiotracer, 18F-SNFT-1, has been found to be more effective than existing tau PET radiotracers in identifying Alzheimer's disease in its earliest stages, according to research published in the September issue of The Journal of Nuclear Medicine.

29 Sep 2023

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Patients with multiple myeloma, a blood cancer of plasma cells in the bone marrow, who also have diabetes have a reduced overall survival when compared to those without diabetes.

29 Sep 2023

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

29 Sep 2023

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Number of patient participants needed for secondary approval of a new cancer drug.

29 Sep 2023

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

28 Sep 2023

Swapping meat for Quorn protein could reduce cholesterol and trim waist circumference

People looking to reduce their cholesterol and trim fat from around their waist could try swapping meat for Quorn protein, according to the findings from a new study by Northumbria University, Newcastle, published in the European Journal of Nutrition, which saw positive effects in both areas in just two weeks.

28 Sep 2023

New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

Loss of the "housekeeping" gene methylthioadenosine phosphorylase, or MTAP, is a common event in cancer.

28 Sep 2023

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

New Cleveland Clinic-led research shows commonly used COVID-19 anti-viral drugs Paxlovid (nirmatrelvir) and Lagevrio (molnupiravir) reduce risk of hospitalization and death in high-risk patients with mild disease, even with Omicron subvariants.

28 Sep 2023

Brain compensation may delay worsening of Parkinson's symptoms

In Parkinson's disease, the cerebral cortex can take over tasks from a deeper part of the brain that has been damaged, where cells that make dopamine have been lost.

28 Sep 2023

Deviations from normal pattern of sleep and physical activity could predict preterm birth risk

A lack of sleep and reduced physical activity during pregnancy are linked to risk of preterm birth, according to new research led by the Stanford School of Medicine.

28 Sep 2023

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.

28 Sep 2023

Hotter days in New York linked to spike in substance abuse hospital visits

New study finds a positive correlation between rising temperatures and increased hospital visits for alcohol and substance-related disorders in New York State. The research suggests that climate change could exacerbate negative outcomes related to substance abuse.

27 Sep 2023

Researchers develop new way to boost immune cells' ability to fight TB

Tuberculosis is old - ancient even. The infectious bacterial disease that plagued Old Testament Israelites and took down pharaohs was eventually stunted by vaccinations, antibiotics, and public health measures like isolation, but it hasn't been cured yet.

27 Sep 2023

Drugs News and Research

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Could plant-based phytonutrients be the secret weapon against obesity?

Cancer cells hijack enhancer DNA to grow faster, study finds

New tau PET radiotracer shows promise for early detection of Alzheimer's disease

Racial disparities in survival rates among patients with multiple myeloma and diabetes

Parasites that cause visceral leishmaniasis can infect non-immune cells, study finds

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Swapping meat for Quorn protein could reduce cholesterol and trim waist circumference

New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

Brain compensation may delay worsening of Parkinson's symptoms

Deviations from normal pattern of sleep and physical activity could predict preterm birth risk

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Hotter days in New York linked to spike in substance abuse hospital visits

Researchers develop new way to boost immune cells' ability to fight TB

HMS researcher to lead $104 million effort to study bacteria and antibiotic resistance

Blocking Notch signaling pathway could reverse age-related bone loss

Small and precise CRISPR-Cas13bt3 system can be used to shred viruses

Medication and mutations: molnupiravir's impact on SARS-CoV-2 genomes

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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