immunity News and Research

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Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

A new study by US-based researchers describes the results of a study on the immune response among healthcare workers, in particular, their T cell responses predating the pandemic.

19 Jan 2021

Large study finds SARS-CoV-2 viral load is lowest in children

A new study by researchers in the Netherlands confirms the hypothesis that for SARS-CoV-2 infection, higher age is associated with increased viral loads.

19 Jan 2021

What are the key factors and impact of interventions in England’s COVID-19 epidemic?

Researchers from Imperial College London provide a mathematical model to help understand how SARS-CoV-2, the causative pathogen of (COVID-19), spread across England in the first two waves of the epidemic, and the effect of various interventions by the government.

18 Jan 2021

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

A recent study by US researchers shows how the 501Y.V2 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), characterized by several mutations, is able to escape neutralization by present first-wave anti-SARS-CoV-2 antibodies and potentially re-infect COVID-19 convalescent individuals.

17 Jan 2021

National consortium to study the effects of emerging SARS-CoV-2 mutations

A new national research project to study the effects of emerging mutations in SARS-CoV-2 will be launched with £2.5 million of funding from UK Research and Innovation.

15 Jan 2021

5 reasons to wear a mask even after you’re vaccinated

As an emergency physician, Dr. Eugenia South was in the first group of people to receive a covid vaccine. She received her second dose last week — even before President-elect Joe Biden.

15 Jan 2021

Computational method uses heat map data to reverse engineer 3D chromosome models

Genome analysis can provide information on genes and their location on a strand of DNA, but such analysis reveals little about their spatial location in relation to one another within chromosomes -- the highly complex, three-dimensional structures that hold genetic information.

15 Jan 2021

Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers

Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response.

15 Jan 2021

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

It was also classified as a "Variant of Concern" (VOC B.1.1.7) in December 2020. First discovered in Kent, United Kingdom, in September 2020, this new variant has since been found in more than 29 countries across the globe, including the USA.

14 Jan 2021

MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials

A new study reports the preclinical testing of a recombinant MVA (rMVA) candidate vaccine against SARS-CoV-2, the agent that is causing the current COVID-19 pandemic.

14 Jan 2021

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

The unchecked advance of COVID-19 has made it a top public health priority to produce a vaccine capable of inducing a safe and powerful protective response against its causative pathogen: SARS-CoV-2. An encouraging new study shows the immunogenicity, safety, and protective efficacy, of a Newcastle disease virus (NDV)-based intranasal vector vaccine in animal studies.

14 Jan 2021

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

A recent study shows that mutated SARS-CoV-2 strains with a substitution at position 501 might have circulated unnoticed even before the end of September 2020, when the rapid emergence of B.1.1.7 lineage (carrying the N501Y mutation) was initially reported.

13 Jan 2021

SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses

What is the endgame for SARS-CoV-2, the virus that is causing worldwide devastation? If it becomes endemic -- circulating in the general population -- and most people are exposed in childhood, SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses that currently circulate in humans, according to a model developed by Emory and Penn State scientists.

13 Jan 2021

Medical institutions should support health care workers with COVID-19 infection, say experts

By mid-November, the Centers for Disease Control and Prevention had reported that 218,439 health care workers in the U.S. had been infected with COVID-19 -- a likely underestimate due to incomplete data from states.

13 Jan 2021

Researchers develop novel antibody fragments against SARS coronavirus-2

An international research team led by the University of Bonn (Germany) has identified and further developed novel antibody fragments against the SARS coronavirus-2. These "nanobodies" are much smaller than the classic antibodies used to treat US President Donald Trump, for example.

13 Jan 2021

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

DiosCURE SE announced a publication in Science describing its core technology of multivalent single-chain antibodies with a unique molecular mode-of-action to inactivate SARS-CoV-2 virions. An international team led by scientists at the University of Bonn developed and characterized the lead candidates, which are exclusively licensed by DiosCURE.

13 Jan 2021

Scientists identify sensor in human lungs that detects SARS-CoV-2

Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified the sensor in human lungs that detects SARS-CoV-2 and signals that it's time to mount an antiviral response.

13 Jan 2021

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

A short paper that appeared recently on the preprint bioRxiv server pointed to a link between specific characteristics of anti-SARS-CoV-2 antibodies associated with the severity of COVID-19.

12 Jan 2021

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

A new preprint that appeared on the bioRxiv server reports that intranasal vaccination with the D614G variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus monkeys reduces viral shedding. This is an experiment in non-human primates (NHP), and its extrapolation to humans is unclear as yet.

12 Jan 2021

immunity News and Research

Gene-cutting system may play second role as a genetic dimmer switch

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

Large study finds SARS-CoV-2 viral load is lowest in children

What are the key factors and impact of interventions in England’s COVID-19 epidemic?

Study reveals possible SARS-CoV-2 escape mutant that may re-infect immune individuals

National consortium to study the effects of emerging SARS-CoV-2 mutations

5 reasons to wear a mask even after you’re vaccinated

Computational method uses heat map data to reverse engineer 3D chromosome models

Targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers

Phylogenetic analyses shows SARS-CoV-2 variant B.1.1.7 originated in the UK

MVA SARS-CoV-2 vaccine candidate shows strong immunogenicity in preclinical trials

Could intranasal SARS-CoV-2 vaccines be a practical alternative to intramuscular shots?

New N501 SARS-CoV-2 mutation may have been circulating in Italy since August 2020

SARS-CoV-2 may join the ranks of mild cold-causing coronaviruses

Medical institutions should support health care workers with COVID-19 infection, say experts

Researchers develop novel antibody fragments against SARS coronavirus-2

New publication describes DiosCURE’s multivalent single-chain antibodies to inactivate SARS-CoV-2

Scientists identify sensor in human lungs that detects SARS-CoV-2

Antibody-Fc-mediated innate immunity shapes COVID-19 severity

Intranasal vaccination effectively reduces viral shedding of SARS-CoV-2 in monkeys

Industry Focus eBook - Cell biology (5th edition) eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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