Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Researchers to develop new test to predict therapy for women with ER+ breast cancer

Researchers from Case Western Reserve University are teaming with industry and other academics to develop a quick and inexpensive test to predict which women with ER+ breast cancer need chemotherapy and which need only the more tolerable hormonal therapy.

11 Jul 2016

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

Columbia University Medical Center and Weill Cornell Medicine, in collaboration with NewYork-Presbyterian and NYC Health + Hospitals/Harlem, have been awarded a grant from the NIH for approximately $4 million in fiscal year 2016 to enroll participants in the Cohort Program of President Barack Obama's Precision Medicine Initiative (PMI)—a large-scale research effort to improve our ability to prevent and treat disease based on individual differences in lifestyle, environment and genetics.

11 Jul 2016

AMP looks forward to working with FDA to determine optimal approach to regulating NGS tests

The Association for Molecular Pathology, the premier global, non-profit organization serving molecular diagnostic professionals, today announced that it looks forward to working with the U.S. Food and Drug Administration to determine the best adaptive approach to regulating Next-Generation Sequencing (NGS) tests.

11 Jul 2016

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Great strides have been made in treating neuroblastoma, the most common cancer in infants and toddlers. However, advanced cases are often fatal, and children who survive often face life-long physical and intellectual challenges related to their treatment.

8 Jul 2016

Study results pave way to development of effective human vaccine against HIV

A new scientific study conducted by a team of leading AIDS scientists reveal results that lead the way to the development of an effective human vaccine against human immunodeficiency virus (HIV).

8 Jul 2016

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Massachusetts General Hospital investigators have discovered the mechanism by which obesity increases inflammation and desmoplasia - an accumulation of connective tissue - in the most common form of pancreatic cancer.

7 Jul 2016

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Inherited mutations in genes that function to repair DNA may contribute to metastatic prostate cancer more than previously recognized, according to a study out today in the New England Journal of Medicine.

7 Jul 2016

Hippocampal inflammation linked to depressive symptoms in patients with multiple sclerosis

Patients with multiple sclerosis have higher rates of depression than the general population, including people with other life-long disabling diseases. Symptoms of multiple sclerosis arise from an abnormal response of the body's immune system.

7 Jul 2016

New ESMO guidelines reflect personalized approach for management of metastatic colorectal cancer

ESMO, the leading European professional organisation for medical oncology, has released new consensus guidelines for the management of metastatic colorectal cancer that reflect an increasingly personalized approach to treatment, as published online today in Annals of Oncology.

7 Jul 2016

Changes in benign tissue adjacent to prostate tumors could better predict recurrence

Changes in benign tissues next to prostate tumors may provide an early warning for patients at higher risk for biochemical recurrence after a radical prostatectomy, a study by researchers at Case Western Reserve University and Johns Hopkins Medical Institutions shows.

6 Jul 2016

Diabetes drug metformin could help reduce toxic acid levels linked to MSUD

Maple Syrup Urine Disease (MSUD) is a rare inherited metabolic disorder involving the dysfunction of an enzyme which breaks down three essential amino acids: leucine, isoleucine and valine.

6 Jul 2016

Proscia completes $1M seed round of financing to advance cancer diagnosis, treatment

Proscia Inc., a data solutions provider for digital pathology, announced today the completion of its $1M seed round of financing.

5 Jul 2016

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

LouLou Foundation and the Orphan Disease Center (ODC) in the Perelman School of Medicine at the University of Pennsylvania are pleased to announce the award of 11 new research grants into CDKL5 deficiency - a rare X-chromosome-linked genetic disorder that causes severe neuro-developmental impairment and early-onset, difficult-to-control seizures.

5 Jul 2016

New mouse model reveals how Alzheimer's causes dementia

Using a novel, newly developed mouse model that mimics the development of Alzheimer's disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological "insults" must occur in the brain to cause the dementia that is the hallmark of the disease.

4 Jul 2016

New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Brain vessel diseases may contribute to Alzheimer's dementia

While strokes are known to increase risk for dementia, much less is known about diseases of large and small blood vessels in the brain, separate from stroke, and how they relate to dementia.

4 Jul 2016

New technique can help identify aggressive forms of DCIS

When a woman is diagnosed with the earliest stage of breast cancer, how aggressive should her treatment be? Will the non-invasive cancer become invasive? Or is it a slow-growing variety that will likely never be harmful?

1 Jul 2016

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD

Scientists from the University of Sheffield have discovered a novel function of the C9orf72 protein which is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) - giving a new insight into the most common genetic cause of the degenerative diseases.

1 Jul 2016

Itaconate can suppress pro-inflammatory activity of macrophages

An international group of scientists from US, Canada, Germany and Russia has revealed a substance produced in humans that can suppress the pro-inflammatory activity of macrophages - specific cells of immune system.

1 Jul 2016

Study shows low incidence of cancer in patients with large colorectal polyps

For the majority of patients with large or difficult to remove colorectal polyps (growths in the colon), the incidence of cancer is actually lower than previously thought, and using more advanced endoscopic techniques that spare the colon may be a better, safer alternative to a traditional operation in certain cases, according to study results published online in the Journal of the American College of Surgeons in advance of print publication.

30 Jun 2016

Pathology News and Research

Further Reading

Researchers to develop new test to predict therapy for women with ER+ breast cancer

Five-year NIH grant awarded to four NYC medical centers for PMI Cohort Program

AMP looks forward to working with FDA to determine optimal approach to regulating NGS tests

Study finds microRNA let-7 plays key role in restricting neuroblastoma

Study results pave way to development of effective human vaccine against HIV

MGH researchers discover how obesity increases inflammation, desmoplasia in PDAC patients

Inherited mutations in DNA repair genes may predispose to metastatic prostate cancer

Hippocampal inflammation linked to depressive symptoms in patients with multiple sclerosis

New ESMO guidelines reflect personalized approach for management of metastatic colorectal cancer

Changes in benign tissue adjacent to prostate tumors could better predict recurrence

Diabetes drug metformin could help reduce toxic acid levels linked to MSUD

Proscia completes $1M seed round of financing to advance cancer diagnosis, treatment

LouLou Foundation, ODC announce 11 new grants for research on CDKL5 deficiency

New mouse model reveals how Alzheimer's causes dementia

New strategy treats fatal autoimmune disease without outward off-target effects

Brain vessel diseases may contribute to Alzheimer's dementia

New technique can help identify aggressive forms of DCIS

Sheffield researchers identify novel function of C9orf72 protein linked to ALS and FTD

Itaconate can suppress pro-inflammatory activity of macrophages

Study shows low incidence of cancer in patients with large colorectal polyps

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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