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5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

Study identifies new cause of inflammation in people living with HIV

While current antiretroviral treatments for HIV are highly effective, data has shown that people living with HIV appear to experience accelerated aging and have shorter lifespans - by up to five to 10 years - compared to people without HIV.

30 Oct 2020

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

Scientists have revealed the molecular mechanism regulating the trafficking of lysosomes that increases the invasiveness of radioresistant cancer cells following radiotherapy.

30 Oct 2020

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Like a key, SARS-CoV-2 - the virus that causes coronavirus disease 2019 (COVID-19) - attaches to specific molecules on the host cell surface, opening gateways into the cell interior.

30 Oct 2020

Study: Toxins produced by tube-dwelling anemones have pharmacological potential

Researchers based in Brazil and the United States have completed the first-ever mapping exercise to profile the toxins produced by tube-dwelling anemones, or cerianthids, a family of marine animals belonging to the same phylum (Cnidaria) as sea anemones, jellyfish and corals.

30 Oct 2020

A2B-COVID: Rapid identification of SARS-CoV-2 transmission

A new study published on the preprint server medRxiv in October 2020 reports a method to assess transmission potential for any event in the current pandemic, using what is known about the virus's spread, data on the mobility of individuals, and new ways of processing genomic sequencing data. The outcome is to determine whether cases are linked or not so as to take action to prevent further spread.

29 Oct 2020

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Researchers from Basel and Spain have identified a novel SARS-CoV-2 variant that has spread widely across Europe in recent months, according to an un-peer-reviewed preprint released this week.

29 Oct 2020

Toxin-carrying virus implicated in the emergence of new Salmonella strain in pigs

Researchers at the Quadram Institute have implicated a toxin-carrying virus in the emergence of a new strain of Salmonella in pigs.

29 Oct 2020

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies, researchers at Children's Hospital of Philadelphia have found significant genetic correlations between inflammatory bowel disease and stress and depression.

29 Oct 2020

Antiviral inhibitor DDX42 shows broad activity against Chikungunya, HIV and SARS-CoV-2

By exploiting type 1 interferon's ability to foster an antagonistic cellular environment for viral replication, a research group from France pinpointed DEAD-box RNA helicase DDX42 as an intrinsic inhibitor of HIV, but also other pathogenic viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Chikungunya virus.

29 Oct 2020

Tumor suppressor gene represses 'jumping genes'

About half of all tumors have mutations of the gene p53, normally responsible for warding off cancer. Now, UT Southwestern scientists have discovered a new role for p53 in its fight against tumors: preventing retrotransposons, or "jumping genes," from hopping around the human genome.

29 Oct 2020

Research shows why certain people infected with COVID-19 show no symptoms

Researchers worldwide have been surprised to see that individuals can be infected with the SARS-CoV-2 virus - the virus that produces COVID-19 - without showing symptoms. Since these individuals expose others to infection without knowing it, it is important to find an explanation and hopefully a solution to this.

29 Oct 2020

Study reveals complex and vast diversity of African genetic variation

The study, in which six Wits researchers were involved, show that these newly discovered variants were found mostly among newly sampled ethnolinguistic groups.

29 Oct 2020

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

By leveraging nucleotide triphosphate analog-induced cell death, Chinese researchers unveiled genes that affect the import, export, and metabolism of pervasively used antiviral drugs in the treatment of coronavirus disease (COVID-19). This exciting study is currently available on the bioRxiv* preprint server.

28 Oct 2020

Genomic analysis of early SARS-CoV-2 epidemic in the UK

By analyzing 50,887 SARS-CoV-2 genomes, the team has provided insights into the micro-epidemiological patterns underlying the features of one of the world's largest national COVID-19 epidemics.

28 Oct 2020

Grant programs will provide $2.2 million to support biomedical research on healthy aging

The Glenn Foundation for Medical Research and the American Federation for Aging Research announce the 2020 recipients of three grant programs: the Glenn Foundation for Medical Research and AFAR Grants for Junior Faculty, the Glenn Foundation for Medical Research Postdoctoral Fellowships in Aging Research, and the Glenn Foundation for Medical Research Breakthroughs in Gerontology Awards.

28 Oct 2020

Study of SARS-CoV-2 outbreak in meat processing plant suggests aerosol transmission in confined places

The importance of maintaining high-quality air flow to restrict transmission of SARS-CoV-2 in confined workspaces has been strongly indicated by the investigation of an outbreak of the virus at a German meat processing plant during May and June 2020.

28 Oct 2020

Researchers describe factors that reduce placenta's capacity to protect fetus from zika virus

Genetic factors that reduce the placenta's capacity to protect the fetus from the zika virus are described by Brazilian researchers in an article published in PLOS Neglected Tropical Diseases.

28 Oct 2020

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

The structure of a 3’ stimulatory pseudoknot in the viral genome or by itself has been proposed recently. Researchers report the structure and mechanisms of mammalian ribosomes during translation of the -1 frameshifting of the SARS-CoV-2 viral genome in a new study published on the preprint server bioRxiv.

28 Oct 2020

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

In the world of rare genetic diseases, exome and genome sequencing are two powerful tools used to make a diagnosis. A recent addition to the toolkit, RNA sequencing, has been demonstrated to help researchers narrow down disease candidate variants identified first on exome and genome sequencing.

28 Oct 2020

Genome News and Research

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Study identifies new cause of inflammation in people living with HIV

Study reveals molecular mechanism that increases the invasiveness of radioresistant cancer cells

SARS-CoV-2 spike proteins can directly impact the blood-brain barrier

Study: Toxins produced by tube-dwelling anemones have pharmacological potential

A2B-COVID: Rapid identification of SARS-CoV-2 transmission

Researchers identify a novel SARS-CoV-2 variant that spread widely across Europe in summer 2020

Toxin-carrying virus implicated in the emergence of new Salmonella strain in pigs

Study suggests a role for the hypothalamus in genetic susceptibility to IBD

Antiviral inhibitor DDX42 shows broad activity against Chikungunya, HIV and SARS-CoV-2

Tumor suppressor gene represses 'jumping genes'

Research shows why certain people infected with COVID-19 show no symptoms

Study reveals complex and vast diversity of African genetic variation

Genome-wide CRISPR screens reveal resistance and sensitization mechanisms of drugs used in COVID-19

Genomic analysis of early SARS-CoV-2 epidemic in the UK

Grant programs will provide $2.2 million to support biomedical research on healthy aging

Study of SARS-CoV-2 outbreak in meat processing plant suggests aerosol transmission in confined places

Researchers describe factors that reduce placenta's capacity to protect fetus from zika virus

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

Genetic analysis with RNA sequencing can increase diagnostic yield, shows study

The art of CRISPR: The power and promise of gene editing eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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