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Wiley expands its KnowItAll solutions with new tools for LC-MS analysis, enterprise data management, and additional spectral advances

The latest KnowItAll software accelerates spectral analysis, featuring automated LC-MS tools and extensive spectral libraries to optimize research workflows.

From John Wiley and Sons - Scientific Publishers 11 Dec 2024

Study reveals gut microbiome’s person-specific role in glycemic sensitivity

Research reveals how individual gut microbiota responses to high-carbohydrate diets influence glycemic sensitivity, paving the way for personalized nutrition.

11 Dec 2024

Mayo Clinic researchers advocate for comprehensive TPMT genotyping across ancestries

Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent. A novel study in The Journal of Molecular Diagnostics, published by Elsevier, details the researchers' goal to provide pharmacogenomic testing that can be used clinically to predict drug response that is beneficial to all patients, regardless of their ancestral background.

11 Dec 2024

Chemical footprints of breast cancer: A new exposomics approach

Researchers in Sweden explored chemical exposures in plasma samples and uncovered links between environmental factors and breast cancer risk influenced by age, parity, and menarche.

10 Dec 2024

New method detects unrecognized chemicals in the human body

From the 1960s to the 1980s, the use of lead in fuel, paints, and pipes caused widespread contamination.

6 Dec 2024

Liver conversion of fructose fuels cancer growth by supplying lipids for tumor proliferation

This research highlights the indirect role of fructose in cancer, revealing how liver metabolism enhances tumor growth through lipid-mediated mechanisms.

5 Dec 2024

Gut microbiome and brain evolution: New insights into energy allocation

Gut microbiota from primates with larger brains promotes glucose production and energy allocation for brain function, shedding light on metabolic strategies in evolution.

4 Dec 2024

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Scientists uncover coffee's surprising effect on gut microbiota

Scientists reveal that coffee consumption influences gut microbiota composition, with a strong link to the bacterium Lawsonibacter asaccharolyticus, independent of caffeine.

3 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

Gut transit time and pH shape microbiome individuality and dietary responses

Scientists reveal gut transit time and pH as key drivers of microbiome and metabolic individuality, paving the way for personalized dietary strategies.

1 Dec 2024

Innovative annatto-based therapy shows promise for treating pediatric halitosis

A study by researchers working in Brazil shows that antimicrobial photodynamic therapy in which blue light targets annatto colorant is a feasible and effective option for treatment of halitosis in mouth-breathing children.

27 Nov 2024

MR1 molecule and vitamin B6 could unlock new paths for cancer immunotherapy

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1.

27 Nov 2024

Study reveals how liver bile composition changes during enteric infections

Intestinal infections can change the composition of liver bile, leading to changes in immune function and gut bacteria, potentially helping fight off harmful bacteria .

26 Nov 2024

How neural and hormonal gut-brain communication shapes metabolism and health

Interoception research reveals how gut-brain communication via neural, hormonal, and microbial pathways regulates metabolism, hunger, and overall health, offering insights for therapeutic innovations.

25 Nov 2024

New technology enables rapid detection of TNT metabolites in the human body

Recently, a research group led by Prof. HUANG Chaoqun from the Hefei lnstitutes of Physical Science of the Chinese Academy of Sciences, developed an innovative dual drift tube ion mobility spectrometry (DDT-IMS) technology.

22 Nov 2024

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option in combination with temozolomide.

21 Nov 2024

How alcohol impacts male health

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, emphasizing the complex mechanisms and public health implications.

18 Nov 2024

Green tea kombucha could transform your gut and boost your weight-loss journey

Green tea kombucha improves gastrointestinal symptoms and alters the serum metabolome in individuals with excess body weight on an energy-restricted diet, showing potential metabolic health benefits.

18 Nov 2024

How vitamin B3 could be the secret to living longer and protecting your heart

Dietary niacin intake reduces risks of all-cause and cardiovascular mortality in US adults, with benefits more pronounced in non-diabetic individuals and linked to NAD metabolism improvements.

18 Nov 2024