Transcription Factors News and Research

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Scientists may have discovered new way to repair damaged tissue

By transforming human scar cells into blood vessel cells, scientists at Houston Methodist may have discovered a new way to repair damaged tissue. The method, described in an upcoming issue of Circulation (early online), appeared to improve blood flow, oxygenation, and nutrition to areas in need.

9 Nov 2014

Induced neural stem cells hold promise for therapeutic transplantation

Induced neural stem cells (iNSCs) created from adult cells hold promise for therapeutic transplantation, but their potential in this capacity has been limited by failed efforts to maintain such cells in the desirable multi-potent NSC state without continuous expression of the transcription factors used initially to reprogram them.

7 Nov 2014

Inventiva’s IVA337 receives EMA COMP positive opinion on orphan drug designation for SSc treatment

Inventiva, a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets, today announces that the Committee for Orphan Medicinal Products (COMP) at the European Medicines Agency (EMA) has given a positive opinion on the designation of IVA337 as an orphan medicinal product.

4 Nov 2014

Epicure project: an interview with Frédéric Cren

Epicure is a project led by Inventiva and Institut Curie that aims to deliver pre-clinical candidates on two novel epigenetic targets that have been selected due to their potential to activate immune responses against cancer cells. In addition one of these two targets has potential in respiratory indications such as asthma or COPD.

3 Nov 2014

Researchers identify genetic variant in Latina women that protects against breast cancer

An international research collaboration led by UC San Francisco researchers has identified a genetic variant common in Latina women that protects against breast cancer.

20 Oct 2014

Research: Ageing and depression are associated with epigenetic changes

Psychological stress and stress-related psychiatric disorders are associated with increased risk for aging-related diseases, but the molecular mechanisms underlying this relation are unknown.

20 Oct 2014

Blocking STAT3 in immune system cells increases anti-tumour immunity

The STAT transcription factors are involved in the development of many forms of cancer. STAT3 is frequently activated in tumour cells, so drugs targeting STAT3 could be used in cancer therapy. However, STAT3 is also important in the development of the immune system. Dagmar Gotthardt and colleagues at the Vetmeduni Vienna now show that blocking STAT3 in cells of the immune system actually leads to increased anti-tumour immunity. Anti-STAT3 therapy may thus be highly promising.

13 Oct 2014

New model predicts replication rate in genome-wide studies based on SNP characteristics

To reduce false positives when identifying genetic variations associated with human disease through genome-wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014.

9 Oct 2014

High-throughput ChIP analysis platform introduced in new technical article

Porvair Sciences, in conjunction with researchers at Swansea University (UK) have written a new technical article entitled 'Chromatrap® 96: a new solid-state platform for high-throughput Chromatin Immunoprecipitation (ChIP)'.

From Chromatrap® - Porvair Sciences Ltd 24 Sep 2014

MIT engineers find new strategy to combat superbugs

In recent years, new strains of bacteria have emerged that resist even the most powerful antibiotics. Each year, these superbugs, including drug-resistant forms of tuberculosis and staphylococcus, infect more than 2 million people nationwide, and kill at least 23,000. Despite the urgent need for new treatments, scientists have discovered very few new classes of antibiotics in the past decade.

22 Sep 2014

Curie-Cancer, Inventiva launch Epicure project that aims to develop epigenetic targets for cancer

Curie-Cancer, the body responsible for developing Institut Curie’s industry partnership activities, and Inventiva, a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets, today announce the launch of the Epicure project, which has just received financial backing from France’s national research agency, the ANR [Agence Nationale pour la Recherche].

17 Sep 2014

Scientists identify developmental on-off switch for Streptomyces

Scientists have identified the developmental on-off switch for Streptomyces, a group of soil microbes that produce more than two-thirds of the world's naturally derived antibiotic medicines.

30 Aug 2014

Dartmouth researchers evaluate role of assortativity signature on robustness

Dartmouth researchers explored the type and number of connections in transcription factor networks (TFNs) to evaluate the role assortativity plays on robustness in a study published in PLOS Computational Biology in August.

30 Aug 2014

Researchers explore connections in TFNs to evaluate role assortativity plays on robustness

30 Aug 2014

UT Southwestern faculty awarded CPRIT grants to combat cancer

UT Southwestern Medical Center faculty have received 19 grants totaling more than $26 million from the Cancer Prevention and Research Institute of Texas to expand cancer screenings, investigate the effectiveness and viability for cancer therapies and radiation treatments, conduct research into cancer biology, and recruitment.

29 Aug 2014

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

How much is currently known about what happens in the developing brain that puts people at risk of schizophrenia?

11 Aug 2014

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

The circadian rhythm is affected by many different stimuli—such as sleep and light, which are the most broadly appreciated ways—but also eating— all of which can modulate, or change, important processes in our bodies such as temperature, production of hormones or other signalling small molecules, cellular regeneration, and others.

6 Aug 2014

Xbp1s protein plays key role in brain regions to regulate metabolism

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

26 Jul 2014

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

A protein that controls when genes are switched on or off plays a key role in specific areas of the brain to regulate metabolism, UT Southwestern Medical Center researchers have found.

25 Jul 2014

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

Our immune system contains CD8+ T cells which protect us from various diseases such as cancer and viruses. Some of them are specifically tasked with killing cells infected with the HIV virus - and researchers from Karolinska Institutet in Sweden, together with international colleagues, have for the first time identified a key explanation for why these cells are unsuccessful in their task.

18 Jul 2014

Transcription Factors News and Research

Scientists may have discovered new way to repair damaged tissue

Induced neural stem cells hold promise for therapeutic transplantation

Inventiva’s IVA337 receives EMA COMP positive opinion on orphan drug designation for SSc treatment

Epicure project: an interview with Frédéric Cren

Researchers identify genetic variant in Latina women that protects against breast cancer

Research: Ageing and depression are associated with epigenetic changes

Blocking STAT3 in immune system cells increases anti-tumour immunity

New model predicts replication rate in genome-wide studies based on SNP characteristics

High-throughput ChIP analysis platform introduced in new technical article

MIT engineers find new strategy to combat superbugs

Curie-Cancer, Inventiva launch Epicure project that aims to develop epigenetic targets for cancer

Scientists identify developmental on-off switch for Streptomyces

Dartmouth researchers evaluate role of assortativity signature on robustness

Researchers explore connections in TFNs to evaluate role assortativity plays on robustness

UT Southwestern faculty awarded CPRIT grants to combat cancer

Schizophrenia-linked genetic variations and the developing brain: an interview with Prof. Guo-li Ming

Altering the circadian rhythm: an interview with Dr. Doug Kojetin, The Scripps Research Institute

Xbp1s protein plays key role in brain regions to regulate metabolism

Study identifies molecular mechanisms could lead to new therapies to treat obesity, diabetes

Researchers identify key explanation for why immune system unsuccessful in killing HIV virus

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