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New delivery system could improve the effectiveness of peptide-based cancer vaccines

Researchers at the Terasaki Institute for Biomedical Innovation have developed an innovative delivery system that could significantly improve the effectiveness of peptide-based cancer vaccines, according to a new study published in Advanced Functional Materials.

28 Jan 2025

$Combined therapy could revolutionize the prevention of osteoporosis fractures$

Combined therapy could revolutionize the prevention of osteoporosis fractures

Osteoporosis is a disease in which bone resorbs faster than it is formed, gradually weakening its structure over time and leading to fractures.

28 Jan 2025

Establishing common nomenclature for mitochondria transfer and transplantation

Most animal, plant and fungal cells contain organelles called mitochondria. These descendants of a primordial bacterial endosymbiont still preserve distinct genes and are known for their ability to create ATP as chemical energy.

27 Jan 2025

New nanosystem offers hope for improved diagnosis and treatment of tongue cancer

A pioneering study has unveiled the Au-HN-1 nanosystem, a cutting-edge approach that promises to transform the diagnosis and treatment of tongue squamous cell carcinoma (TSCC).

27 Jan 2025

Breakthrough gene discovery offers new hope for medulloblastoma therapy

Scientists at The Hospital for Sick Children (SickKids) have identified a key gene that could lead to next-generation treatments for medulloblastoma, the most common malignant brain tumor in children.

24 Jan 2025

NUS researchers develop DNA barcoded nanoparticles for targeted cancer therapy

A team of researchers from the National University of Singapore (NUS) has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA barcodes.

24 Jan 2025

Researchers elucidate the significance of birth in neural stem cell maintenance

A research group led by Kazunobu Sawamoto, a professor at Nagoya City University and National Institute for Physiological Sciences, and Koya Kawase, a pediatric doctor at Nagoya City University Hospital, has elucidated the significance of birth in the maintenance of neural stem cells (NSCs).

24 Jan 2025

Research develops framework to compare lab, AI, and simulation data

The successful and safe delivery of therapeutics relies on understanding how easily drugs can pass through biological barriers which protect cells.

24 Jan 2025

Researchers identify ferroptosis as driver of osteocyte death in melanoma metastasis

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain.

23 Jan 2025

New approach to treating ependymoma with leukemia drug

Rakesh Jain PhD, Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.

23 Jan 2025

Microplastics in the bloodstream may pose hidden risks to brain health

Trapped immune cells laden with microplastics starve the brain of oxygen—mouse study links vascular blockages to memory loss and motor deficits, with lingering risks even after symptoms fade.

23 Jan 2025

New air-liquid interface method enhances hair follicle formation in skin organoids

For decades, creating human skin models with physiological relevance has been a persistent challenge in dermatological research.

22 Jan 2025

The science of silk fibroin and chitosan: Techniques for biomaterials analysis

An interview on how advanced techniques can be used to enhance silk fibroin and chitosan for drug delivery applications.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 21 Jan 2025

Manuka vs. Ohia Lehua honey: Study reveals key antioxidant differences and health benefits

Study compares the antioxidant properties of Manuka honey (MH) and Ohia Lehua honey (OLH), revealing that MH contains ten times more phenolic content, while OLH demonstrates superior in vivo antioxidant activity by reducing oxidative stress and enhancing antioxidant capacity.

19 Jan 2025

Exploring the role of EpCAM in early-stage hepatocellular carcinoma progression

Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors.

17 Jan 2025

RNA damage plays key role in sunburn reaction

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study by the University of Copenhagen and Nanyang Technological University, Singapore, reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

17 Jan 2025

New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Pharmacokinetics of berberine and astragaloside IV in normal and diabetic rats

Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats.

15 Jan 2025

Gut microbes revealed as hidden drivers of aging and cellular decline

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial dysfunction and DNA damage, offering insights into therapeutic interventions for age-related decline.

14 Jan 2025

Sapio Sciences Announces Enhanced Capabilities for Chemistry, Immunogenicity, GMP and Molecular Biology

Sapio Sciences' Release 24.12 enhances lab informatics with improved GMP workflows and molecular biology features, driving efficiency and scientific discovery.

From Sapio Sciences 14 Jan 2025