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Cellular and molecular map of the human heart could guide personalized medicine

Scientists have created a cellular and molecular map of the healthy human heart, to understand how this vital organ functions, and to shed light on what goes wrong in cardiovascular disease.

24 Sep 2020

Molecular analysis of COVID-19's second wave shows mutant viruses linked to rapid spread

Molecular analysis of COVID-19's powerful second wave in Houston – from May 12 to July 7 – shows a mutated virus strain linked to higher transmission and infection rates than the coronavirus strains that caused Houston's first wave.

24 Sep 2020

Elegant, efficient way to find recombinant SARS-CoV-2 viruses from >85,000 genomes

The low divergence of near-identical genomes that are sequenced in short periods presents a statistical challenge that is not addressed by methods available currently. In a recent bioRxiv** paper, Ales Varabyou et al. from John Hopkins University present an efficient method designed to detect recombination and reassortment events between clades of viral genomes – a new algorithm called ‘Bolotie’.

23 Sep 2020

Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

Researchers at Tsinghua University, Beijing, have conducted a study providing possible new insights into the evolution and cross-species transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

23 Sep 2020

OXGENE launches a scalable, plasmid-free manufacturing system for AAV

OXGENE™, a biotechnology company designing and developing scalable gene therapy technologies, has today announced the launch of its scalable, plasmid-free manufacturing system for AAV.

From OXGENE 23 Sep 2020

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Using bioinformatics approaches, researchers have identified genes and pathways shared among patients with comorbidities and having severe COVID-19. The research is published on the preprint server bioRxiv in September 2020.

23 Sep 2020

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

The current COVID-19 pandemic has spread throughout the world. Caused by a single-stranded RNA betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is closely related to but much more infectious than the earlier highly pathogenic betacoronaviruses SARS and MERS-CoV, has impacted social, economic, and physical health to an unimaginable extent.

23 Sep 2020

Confirmed early re-infection with SARS-CoV-2

As scientists strive to develop commercially viable and effective antivirals and vaccines to counter the growing COVID-19 pandemic, there is considerable uncertainty about how long and how durable the immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is. A new paper recently published in the journal Clinical Infectious Disease in September 2020 reports a confirmed case of re-infection with this virus following recovery.

22 Sep 2020

Study shows key genetic differences in ADHD between African American and Caucasian children

Researchers from Children's Hospital of Philadelphia have shown there may be key genetic differences in the causes of attention-deficit hyperactivity disorder between African Americans and people of European ancestry, which may play an important part in how patients of different ethnic backgrounds respond to treatments for this condition.

22 Sep 2020

NAU researcher awarded $3.75 million NCI grant to build cancer research software

Greg Caporaso, director of the Center for Applied Microbiome Science, part of the Pathogen and Microbiome Institute at Northern Arizona University, has been awarded a $3.75 million grant by the National Cancer Institute to build software capable of analyzing and archiving data focused on the interplay between the human microbiome (the trillions of microorganisms living in and on the human body) and diverse types of cancer.

22 Sep 2020

Researchers identify a potential drug candidate for hand, foot and mouth disease

A study appearing next week in the journal Nature Communications offers some good news in the search for antiviral drugs for hard-to-treat diseases. Researchers have identified a potential new drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children

22 Sep 2020

Inhibition of SARS-CoV-2 with antisense oligonucleotides

A part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA is highly conserved. Researchers have used this as a target for designing antisense oligonucleotide gapmers to cleave the RNA and disrupt virus replication. Their research is published as a preprint on the online server bioRxiv in September 2020.

22 Sep 2020

FDA proposes new rule that lays the foundation for end-to-end food traceability

Today, I am excited to announce an important, critical step forward in the U.S. Food and Drug Administration's efforts to bring about farm-to-table traceability in our food supply.

22 Sep 2020

Researchers identify genetic markers linked to higher risk of capecitabine-induced hand-foot syndrome

Capecitabine is a chemotherapy drug used for breast and colorectal Cancer cancer. It can extend survival rate by nearly 10%.

21 Sep 2020

Research underlines SARS-CoV-2 N-terminal domain of Nsp1 as a potential drug target

A recent study reveals how the non-structural protein 1 (NSP1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a crucial role in inhibiting the host cell protein synthesis but simultaneously facilitating the viral protein synthesis.

21 Sep 2020

Research uncovers potential cause of neurotoxicity due to immunotherapy

New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

21 Sep 2020

Genomic adaptations to rice‐based diets contribute to mitigation of metabolic risk

The traditional rice-based diet of some east-Asian population has brought to a number of genomic adaptations that may contribute to mitigating the spread of diabetes and obesity.

21 Sep 2020

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause for the disease

21 Sep 2020

Study indicates an ancient explanation on link between humans and long-lived primate

Many humans live to see their 70s and 80s, some even reach 100 years old. But life is much shorter for our closest animal relatives. Chimpanzees, for example, rarely make it past age 50, despite sharing almost 99% of our genetic code.

21 Sep 2020

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

A recent study published on the preprint server bioRxiv* seeks to establish the pattern of antibody reactivity in COVID-19 convalescent plasma (CCP), which is widely being used as a therapy for seriously ill COVID-19 patients.

21 Sep 2020

Genome News and Research

Cellular and molecular map of the human heart could guide personalized medicine

Molecular analysis of COVID-19's second wave shows mutant viruses linked to rapid spread

Elegant, efficient way to find recombinant SARS-CoV-2 viruses from >85,000 genomes

Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

OXGENE launches a scalable, plasmid-free manufacturing system for AAV

Bioinformatics analysis reveals genes and pathways shared in COVID-19 disease and comorbidities

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

Confirmed early re-infection with SARS-CoV-2

Study shows key genetic differences in ADHD between African American and Caucasian children

NAU researcher awarded $3.75 million NCI grant to build cancer research software

Researchers identify a potential drug candidate for hand, foot and mouth disease

Inhibition of SARS-CoV-2 with antisense oligonucleotides

FDA proposes new rule that lays the foundation for end-to-end food traceability

Researchers identify genetic markers linked to higher risk of capecitabine-induced hand-foot syndrome

Research underlines SARS-CoV-2 N-terminal domain of Nsp1 as a potential drug target

Research uncovers potential cause of neurotoxicity due to immunotherapy

Genomic adaptations to rice‐based diets contribute to mitigation of metabolic risk

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

Study indicates an ancient explanation on link between humans and long-lived primate

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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