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Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Results of a small, but unique research study, led by researchers from the Seaver Autism Center for Research and Treatment at Mount Sinai and published online in Human Genetics and Genomic Advances, suggest that low-dose ketamine is generally safe, well-tolerated and effective to treat clinical symptoms in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.

6 Sep 2022

Novel method can be used to study the resistance profile of bacteria that cause meningitis

A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis – an inflammation of the membranes that envelop the brain and spinal cord – are resistant to antibiotics.

6 Sep 2022

Lactate may have a previously unrecognized role in fighting cancer

A new study by UT Southwestern's Simmons Cancer Center scientists suggests that lactate, a metabolic byproduct produced by cells during strenuous exercise, can rejuvenate immune cells that fight cancer.

6 Sep 2022

The existing molecular variance levels in haplotypes of the interferon-alpha-beta receptor gene in Orthopoxviruses

Researchers performed an analysis of molecular variance in 59 haplotypes of the IFNAR gene, departing from monkeypox virus, camelpox virus, buffalopox virus, ectromelia virus, cowpox virus, rabbitpox virus, variola virus, and vaccinia virus.

6 Sep 2022

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

2 Sep 2022

UTHSC team wins $2.13 million NINDS award to study early neuron development

The National Institute of Neurological Disorders and Stroke has awarded $2.13 million to a University of Tennessee Health Science Center (UTHSC) team studying how neural cells that build a functional brain are generated during embryonic and neonatal life.

2 Sep 2022

Understanding how microglia change their states to adapt to different areas of the brain

In this interview, News Medical speaks to Jeffrey Stogsdill, Ph.D., about his latest research exploring how microglia change their state to adapt to different areas of the brain.

2 Sep 2022

Depletion of reactive astrocytes regresses glioblastoma

A groundbreaking study at Tel Aviv University effectively eradicated glioblastoma, a highly lethal type of brain cancer. The researchers achieved the outcome using a method they developed based on their discovery of two critical mechanisms in the brain that support tumor growth and survival: one protects cancer cells from the immune system, while the other supplies the energy required for rapid tumor growth. The work found that both mechanisms are controlled by brain cells called astrocytes, and in their absence, the tumor cells die and are eliminated.

2 Sep 2022

Horizontal gene transfer plays an essential role in keeping microbiomes healthy

Biomedical engineers at Duke University have demonstrated a microbial community phenomenon that essentially equates to teaching neighbors how to complete necessary tasks by ripping out and sharing parts of the brain.

2 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Researchers identify how some cancer cells cheat treatment-induced cell death

Scientists at St. Jude Children's Research Hospital have identified how some cancer cells cheat treatment-induced cell death.

1 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Less is more: early short-course rapamycin effective in sustained anti-aging effects

A new study shows that a brief treatment period could have the same anti-aging efficacy and duration of effect but without the potentially serious adverse effects of chronic administration.

1 Sep 2022

How does origin impact antiviral immune response?

A new study observed differential antiviral responses in Indian and European individuals.

1 Sep 2022

Detection of a novel bird flu virus with pandemic potential

A recent virological study published in the Emerging Infectious Diseases journal identified the novel influenza A virus (H3N8) in live poultry in Hong Kong, genetically similar to the zoonotic H3N8 viruses reported in mainland China with its origin akin to H5N1, H5N6, H10N8, and H7N9 viruses.

31 Aug 2022

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

All normal human tissues acquire mutations over time. Some of these mutations may be driver mutations that promote the development of cancer through increased proliferation and survival, while other mutations may be neutral passenger mutations that have no impact on cancer development.

30 Aug 2022

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

Brain activity patterns during sleep shed light on the neurobiology behind 22q11.2 Deletion Syndrome

The brain activity patterns during sleep shed light on the neurobiology behind a genetic condition called 22q11.2 Deletion Syndrome (22q11.2DS) and could be used as a biomarker to detect the onset of neuropsychiatric disorders in people with 22q11.2DS.

30 Aug 2022

Genes News and Research

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Novel method can be used to study the resistance profile of bacteria that cause meningitis

Lactate may have a previously unrecognized role in fighting cancer

The existing molecular variance levels in haplotypes of the interferon-alpha-beta receptor gene in Orthopoxviruses

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

UTHSC team wins $2.13 million NINDS award to study early neuron development

Understanding how microglia change their states to adapt to different areas of the brain

Depletion of reactive astrocytes regresses glioblastoma

Horizontal gene transfer plays an essential role in keeping microbiomes healthy

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Researchers identify how some cancer cells cheat treatment-induced cell death

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Less is more: early short-course rapamycin effective in sustained anti-aging effects

How does origin impact antiviral immune response?

Detection of a novel bird flu virus with pandemic potential

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Brain activity patterns during sleep shed light on the neurobiology behind 22q11.2 Deletion Syndrome

eBook: Using iPSCs models for human disease research and drug discovery eBook

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