Efficacy News and Research

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The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Researchers select and study an RDV-resistant virus by serial passaging of wild type SARS-CoV-2 in the presence of increasing concentrations of RDV.

15 Feb 2022

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

There is currently no effective treatment for facioscapulohumeral muscular dystrophy (FSHD), one of the most common neuromuscular diseases, which is caused by an abnormal expression of the transcription factor DUX4.

15 Feb 2022

New approach to alter the skin microbiome and reduce acne lesions using bacteria

Acne on the face is often treated with topical antibiotics, which tend to be used for an extended period of time and contribute to the serious problem of antibiotic resistance.

15 Feb 2022

Novel combination therapeutic approach could increase survival of pancreatic cancer patients

A novel combination treatment approach extended survival in mice with pancreatic cancer, demonstrating a potential second-line therapy for patients, according to findings published in Proceedings of the National Academy of Sciences.

15 Feb 2022

Post-vaccination titers of neutralizing antibodies revealed as a moderate predictor of vaccine-induced immunity

In a new study, researchers investigated whether neutralizing antibodies against the SARS-CoV-2 spike protein offered adequate immunity against breakthrough infections among vaccinated individuals.

15 Feb 2022

Antiviral activity assessment of remdesivir against 10 current and former SARS-CoV-2 variant clinical isolates

A new study published demonstrated the in vitro potencies of RDV and GS-441524 through PRA, and nucleoprotein ELISA against SARS-CoV-2 and other VOC/VOIs isolates with specific substitutions in Nsp12.

15 Feb 2022

Scientists identify potential reasons for COVID-19 vaccine hesitancy in US among individuals with chronic health conditions

A recent survey conducted on the adult population in the United States has identified the most common predictive reasons behind COVID-19 vaccine hesitancy.

15 Feb 2022

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

A recent study posted to the bioRxiv* pre-print server investigated the antiviral potential of N-acylethanolamine acid amidase (NAAA) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the Zika virus (ZIKV).

14 Feb 2022

U of U Health awarded HRSA grant to promote resilience and mental health among health care workers

The Resiliency Center at University of Utah Health has been awarded a three-year grant of $2,955,996 from the US Health Resources and Services Administration for promoting resilience and mental health among the health care workforce.

14 Feb 2022

Real-world data on efficacy and safety of COVID vaccines in Canada

In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy and safety of the coronavirus disease 2019 (COVID-19) vaccines in young and elderly cohorts from Canada.

14 Feb 2022

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

A recent study posted to the medRxiv* preprint server reported the phase one pharmacokinetic and safety data of nirmatrelvir/ritonavir to facilitate its rapid progression to the last stages of clinical trials in coronavirus disease 2019 (COVID-19) patients with mild to moderate disease.

14 Feb 2022

New system produces a 3D interactive map of arrhythmia hotspots in the heart

A new way of treating arrhythmias, including atrial fibrillation (AF) - the most common heart arrhythmia diagnosis in clinical practice - has debuted at UC San Diego Health.

14 Feb 2022

Study explores factors influencing countries with high rates of COVID-19 vaccine acceptance

A new study investigated the various factors affecting the acceptance rate and trust in SARS-CoV-2 vaccines in countries with high rates of vaccination.

14 Feb 2022

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

In a recent study published in Science Translational Medicine, researchers characterized a human antibody targeting betacoronaviruses (β-CoVs).

14 Feb 2022

An alternative strategy targeting furin disrupts SARS-CoV-2 infection cycle

A new study was based on the hypothesis that competitively inhibiting cellular furin and selectively targeting SARS-CoV-2 in the infected viral-producing cells is critical for therapeutic specificity.

14 Feb 2022

Study finds mRNA vaccines induce poor neutralizing antibody response against SARS-CoV-2 variants in dialysis patients

Scientists studied plasma samples from 130 hemodialysis (HD) and 13 peritoneal dialysis patients and showed a poor neutralizing and rapidly decaying antibody response to mRNA vaccines in such individuals.

14 Feb 2022

New research could deliver a breakthrough for kids suffering from severe form of genetic epilepsy

New research from the University of South Australia could deliver a breakthrough for children suffering one of the most severe forms of genetic epilepsy, reducing the frequency of their seizures and improving their quality of life.

14 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Assessing potential allergic reactions in COVID-19 vaccinated patients

Researchers analyze suspected reactions in patients vaccinated with the first and/or second dose of SARS-CoV-2 vaccines.

13 Feb 2022

Real world evidence on acquired immunity from vaccines and SARS-CoV-2 infection

Researchers assess the incidence of SARS-CoV-2 breakthrough cases and reinfections among unvaccinated and vaccinated individuals.

13 Feb 2022

Efficacy News and Research

The in vitro selection of a remdesivir-resistant SARS-CoV-2 mutation

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

New approach to alter the skin microbiome and reduce acne lesions using bacteria

Novel combination therapeutic approach could increase survival of pancreatic cancer patients

Post-vaccination titers of neutralizing antibodies revealed as a moderate predictor of vaccine-induced immunity

Antiviral activity assessment of remdesivir against 10 current and former SARS-CoV-2 variant clinical isolates

Scientists identify potential reasons for COVID-19 vaccine hesitancy in US among individuals with chronic health conditions

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

U of U Health awarded HRSA grant to promote resilience and mental health among health care workers

Real-world data on efficacy and safety of COVID vaccines in Canada

Phase one study of oral SARS-CoV-2 antiviral agent nirmatrelvir

New system produces a 3D interactive map of arrhythmia hotspots in the heart

Study explores factors influencing countries with high rates of COVID-19 vaccine acceptance

Study describes a β-CoV spike protein target for protective antibodies that may facilitate pan-β-CoV vaccine development

An alternative strategy targeting furin disrupts SARS-CoV-2 infection cycle

Study finds mRNA vaccines induce poor neutralizing antibody response against SARS-CoV-2 variants in dialysis patients

New research could deliver a breakthrough for kids suffering from severe form of genetic epilepsy

Nitazoxanide shows promise for COVID-19 treatment in animal model

Assessing potential allergic reactions in COVID-19 vaccinated patients

Real world evidence on acquired immunity from vaccines and SARS-CoV-2 infection

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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