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New study provides promising results for metformin in periodontitis

Periodontitis, a prevalent global health concern, results in the gradual destruction of tooth-supporting tissues and is often exacerbated by oxidative stress conditions and bacterial changes. Current treatment methodologies include mechanical debridement, anti-inflammatory drugs, and regenerative surgery.

4 Aug 2023

Gene expression ratio linked to prognosis in solid tumors

A Ludwig Cancer Research study has identified a pair of genes whose expression by a type of immune cell within tumors is predictive of outcomes for cancer patients and is linked to a vast network of gene expression programs, engaged by multiple cell types in the tumor microenvironment, that control human cancers.

3 Aug 2023

Deep learning improves protein design by 10x

The key to understanding proteins - such as those that govern cancer, COVID-19, and other diseases - is quite simple. Identify their chemical structure and find which other proteins can bind to them. But there's a catch.

3 Aug 2023

Peppermint oil may be new option for pain relief after open heart surgery

The use of essential peppermint oil aromatherapy may ease pain severity after open heart surgery and enhance sleep quality as well, suggest the results of a small comparative clinical trial, published online in the journal BMJ Supportive & Palliative Care.

3 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

GABA-modulating treatments could help tackle cognitive, affective symptoms associated with depression

Depression is a complex condition correlated with multiple differences in brain function and mechanisms. A new paper spanning known data about the neurotransmitter GABA and its principal receptors showcases evidence of the receptors' importance in depression and potential as therapeutic targets.

3 Aug 2023

COVID-19's impact on persons with disabilities in Africa

In 2017, a road accident left Anna Nzioka with two fractures in her right leg. After a series of operations and physiotherapy, she has slowly learned to walk again, although with the aid of a crutch.

3 Aug 2023

Gut microbiome changes have significant effects on cocaine use and cravings

According to the 2021 National Survey on Drug Use and Health, 4.8 million people (ages 12 and up) reported using cocaine within the previous 12 months, and 24,486 people died from an overdose involving cocaine.

3 Aug 2023

Research sheds light on the causes of endometriosis-related pelvic pain

Pelvic pain in women with endometriosis is attributed to neuroinflammation. Researchers investigated biochemical mediators of endometriosis-associated pelvic pain to provide a foundation to identify new drugs to improve symptoms and quality of life.

3 Aug 2023

AGA announces support for the reintroduced Treat and Reduce Obesity Act

The American Gastroenterological Association (AGA) today announced support for the reintroduced Treat and Reduce Obesity Act (TROA), which would expand Medicare coverage to include screening and treatment of obesity from a diverse range of health care providers who specialize in obesity care.

3 Aug 2023

Insilico Medicine's new AI tool shows promise in predicting clinical trial outcomes

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has demonstrated that it can predict the outcome of Phase II to Phase III clinical trial success using its proprietary transformer-based AI clinical trial prediction tool called inClinico with a high degree of accuracy.

3 Aug 2023

Nanoengineered bioink improves tumor model accuracy

Scientists from the Terasaki Institute for Biomedical Innovation have developed a nanoengineered bioink with improved bonding and cross-linking capabilities for 3D bioprinting of tumor models.

3 Aug 2023

Pharmatech: The Art of AI-Driven Drug Design with Exscientia

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Garry Pairaudeau, Chief Technology Officer at Exscientia, about pharmatech, AI, and more.

From Society for Laboratory Automation and Screening (SLAS) 3 Aug 2023

Innovative 3D cell culture platform could replace the use of animals in research

PeptiMatrix is the latest spin-out company from the University of Nottingham, providing access to an innovative 3D cell culture platform that aims to replace the use of animals in research.

3 Aug 2023

TU Graz researchers gain new insights into a light-activated protein switch

Researchers at TU Graz have gained new insights into the functioning of a protein found in bacteria, whose enzymatic activity is activated by blue light.

3 Aug 2023

The mechanisms of triptan using metabolomics and transcriptomics in spontaneous migraine attacks

Researchers discuss the mechanisms of triptans for the treatment of spontaneous migraine attacks by using transcriptomics and metabolomics.

3 Aug 2023

Genome-wide study finds link between CHD1L gene and HIV control

"We searched for human genetic variation that associates with spontaneous control of HIV and identified a novel region in the genome that is only variable in populations of African ancestries," says Professor Jacques Fellay at EPFL's School of Life Sciences.

2 Aug 2023