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APOE4 alters brain immunity and cognition differently in females and males

APOE4 drove sex-specific changes in meningeal immunity, lymphatic drainage, brain lipids, neuroinflammation, and cognition in mouse models, with females showing greater inflammatory and cognitive vulnerability. Suppressing innate immunity improved some cognitive outcomes in female E4/E4 mice but worsened them in male E4/E4 mice, underscoring the need for sex-tailored approaches.

29 Mar 2026

Aging lung cells drive severe inflammation in flu and COVID

Older adults are much more likely to become seriously ill from flu or COVID because aging lung cells can drive excessive immune responses, according to a new study led by researchers at UC San Francisco.

27 Mar 2026

Healthy thymus gland linked to longer life and immune stability

The thymus is a small organ located in the upper chest that plays a central role in the immune system: it produces T cells - specialized immune cells that recognize and fight pathogens.

26 Mar 2026

Mentally active sitting linked to reduced risk of dementia

New research distinguishing between passive and mentally active sitting in association with dementia has found that adults who engaged in extended durations of mentally passive sedentary behaviors had a higher risk of dementia.

26 Mar 2026

Stroke may trigger younger brain patterns in unaffected regions

In a new study published in The Lancet Digital Health, scientists at the USC Mark and Mary Stevens Neuroimaging and Informatics Institute (Stevens INI) have discovered that the brains of people who experience severe physical impairment after a stroke may reorganize themselves in unexpected ways, showing signs of "younger" brain structure in undamaged regions as they adapt to injury.

25 Mar 2026

UT San Antonio study evaluates rapamycin’s potential to promote healthy aging

UT Health San Antonio, the academic health center of The University of Texas at San Antonio (UT San Antonio) is launching a multi-phase clinical study to better understand how the drug rapamycin may promote healthy aging.

25 Mar 2026

Whole wheat diets may reduce the risk of inflammatory bowel disease

Enriching the diet with wheat fiber protects mice against intestinal inflammation, according to a study published by researchers in the Institute for Biomedical Sciences (IBMS) at Georgia State University.

25 Mar 2026

Massive clinical trial investigates brain training to delay dementia onset

An expansive clinical trial led by USF researchers and aimed at delaying the onset of dementia continues to receive major federal support for addressing a public health crisis.

25 Mar 2026

Can collagen supplements really improve your skin?

Investigating collagen peptides, this review explores their role in skin aging, assessing clinical evidence and the mechanisms behind their potential benefits.

25 Mar 2026

Study identifies rare genetic disorder linked to premature aging and cognition

Scientists at Sanford Burnham Prebys Medical Discovery Institute and an international team of collaborators have defined a new genetic disease marked by premature aging and deficits in brain function.

24 Mar 2026

Study reveals genetic impact of Agent Orange on bone marrow cancers

More than 50 years after Agent Orange was used in Vietnam, a new national study published online ahead of print in Blood Advances highlights the genetic changes that link exposure to Agent Orange to myelodysplastic syndromes (MDS), a group of bone marrow cancers that can progress to acute leukemia.

23 Mar 2026

Scientists discover similarities in brain aging between mice and humans

By scanning the brains of mice throughout their lifespans, scientists at Columbia's Zuckerman Institute and the University of Texas at Dallas have discovered that the human brain is not unique in how it changes with age.

23 Mar 2026

Mediterranean diet may protect health through mitochondrial microproteins

A new study led by researchers at the USC Leonard Davis School of Gerontology suggests that the benefits of the Mediterranean diet may be driven, in part, by tiny proteins hidden within our mitochondria, opening a new window into how diet shapes aging and disease risk.

23 Mar 2026

New models predict biological age using blood and microbiome

A new research paper was published in Volume 18 of Aging-US on March 12, 2026, titled "Blood biochemical and gut microbiotic neural network models forecasting human biological age."

23 Mar 2026

Aging and Parkinson’s impact brain and muscle activity during balance recovery

Lena Ting, from Emory University, and colleagues explored how brain and muscle activity during balance recovery change due to aging and Parkinson's.

23 Mar 2026

Study identifies protein that slows cartilage breakdown in joints

Osteoarthritis, a condition that causes pain and reduced mobility in joints such as the knees and fingers, is one of the most common joint disorders worldwide, particularly among aging populations.

23 Mar 2026

Rising health costs push some middle-aged adults to skip the doc until Medicare

John Galvin knows he needs a colonoscopy. But he's waiting to schedule the procedure until December, when he turns 65 and qualifies for Medicare.

23 Mar 2026

Higher meat intake may slow cognitive decline in older adults with APOE ε4

In older Swedish adults, higher meat intake was associated with slower cognitive decline and lower dementia risk among people carrying APOE ε3/ε4 or ε4/ε4, but not among other genotype groups. A higher processed-to-total meat ratio was linked to worse dementia outcomes, while unprocessed red meat and poultry showed no substantial difference.

22 Mar 2026

‘How low can you go?’ The shifting guidelines for blood pressure control

The patient initially came to see Mark Supiano in 2017 because her family was concerned about her short-term memory loss.

20 Mar 2026

Brain age from sleep patterns may signal future dementia risk

A machine-learning analysis of brain waves recorded during sleep may help identify people at high risk of developing dementia, according to a study led by UC San Francisco and Beth Israel Deaconess Medical Center in Boston.

19 Mar 2026