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Genetics play vital role in knee pain sensitivity

Genetics play a key role in knee pain sensitivity, according to a team of researchers studying knee osteoarthritis patients.

20 Jan 2016

Small differences in specific genetic variant could alter nicotine consumption

Nicotine is an addictive substance and genetic factors are known to play a role in smoking behaviors. Recently, a team of researchers at Penn State and the University of Colorado determined how small differences in a particular region of the mouse genome can alter nicotine consumption.

11 Jan 2016

Working Group identifies many potential genetic contributors to weight loss

In the midst of the holiday season, celebratory get-togethers can mean overindulging on treats and high-calorie foods, leaving many of us struggling to keep off the extra pounds. With as many as two-thirds of American adults already carrying excess weight, and one third with obesity, maintaining weight can be the biggest challenge, say researchers.

24 Dec 2015

Perceived stress increases likelihood of amnestic mild cognitive impairment in older people

Feeling stressed out increases the likelihood that elderly people will develop mild cognitive impairment—often a prelude to full-blown Alzheimer's disease. In a new study, scientists at Albert Einstein College of Medicine and Montefiore Health System found that highly stressed participants were more than twice as likely to become impaired than those who were not.

13 Dec 2015

Mayo Clinic investigators discover novel mechanism linked to diabetes risk

Researchers at Mayo Clinic have discovered an unexpected effect from a gene known to increase diabetes risk. They assumed that the specific allele in the gene TCF7L2 which increases the risk of type 2 diabetes, impairs insulin production in response to increased insulin resistance. Some slight evidence of that was found, but more significantly the researchers discovered that this variant impaired a person's ability to balance blood sugar (glucose) by suppressing glucagon - the hormone that raises the level of glucose in the bloodstream.

12 Nov 2015

Baylor Miraca Genetics Laboratories licenses SNP probe technology from OGT

Oxford Gene Technology (OGT), The Molecular Genetics Company, has entered into a deal with Baylor Miraca Genetics Laboratories (BMGL), licensing the use of OGT’s proprietary single nucleotide polymorphism (SNP) array probe technology.

From Oxford Gene Technology 12 Nov 2015

Perisylvian polymicrogyria gene found

Researchers have identified the genetic basis for bilateral perisylvian polymicrogyria, the most common form of regional polymicrogyria.

4 Nov 2015

APOE ε4 predicts risk of future depression

One of the most powerful predictors in neuropsychiatry is the epsilon 4 (ε4) allele of the apolipoprotein gene (APOE).

3 Nov 2015

Single gene variation may influence obesity in children, adults

A single variation in the gene for brain-derived neurotropic factor (BDNF) may influence obesity in children and adults, according to a new study funded by the National Institutes of Health.

30 Oct 2015

Changes in lifestyle could reduce Alzheimer's disease risk

Changes in lifestyle could reduce the risk of developing Alzheimer's disease. That was the conclusion of a study conducted by researchers of Heidelberg University's Network Aging Research, who examined the data from two independent epidemiological studies. Carriers of the ApoE4 genetic risk factor for Alzheimer's may be able to reduce their increased risk of cognitive decline by reducing their cholesterol level, especially if they also suffer from cardiovascular disease.

27 Oct 2015

Findings suggest a potential "early warning" detection system for Alzheimer's disease

The findings suggest a potential "early warning" detection system for Alzheimer's disease, even in young and asymptomatic individuals.

23 Oct 2015

Researchers use cutting edge genomic methods to explain protective effects of malaria vaccine candidate

An international team led by researchers from the Broad Institute of MIT and Harvard, the Harvard T.H. Chan School of Public Health, and Fred Hutchinson Cancer Research Center have used cutting edge genomic methods to uncover key biological insights that help explain the protective effects of the world's most advanced malaria vaccine candidate, RTS,S/AS01 (RTS,S).

22 Oct 2015

ToMMo constructs Japanese population reference panel from genome information of 1,070 individuals

A research group at Tohoku Medical Megabank Organization (ToMMo) has successfully constructed a Japanese population reference panel (1KJPN), from the genome information of 1,070 individuals who had participated in the cohort studies of the Tohoku Medical Megabank Project.

19 Oct 2015

Quest Diagnostics scientists demonstrate new molecular combing technique that predicts cystic fibrosis, muscular dystrophy

Genetic testing for mutations beyond those currently recommended in medical guidelines may aid the identification of more couples at risk of having a child with cystic fibrosis, according to a study presented today at the 2015 American Society of Human Genetics Annual Meeting, which runs through October 10 in Baltimore, Maryland.

From Quest Diagnostics 13 Oct 2015

Cardiac monitoring predicts survival in patients with Friedreich ataxia

Researchers confirm the need for cardiac follow-up in patients with Friedreich ataxia, with particular focus on left ventricular ejection fraction as a predictor of worse prognosis.

12 Oct 2015

IU-led scientists discover new gene that increases Alzheimer's disease risk

In a newly published study, a multi-institutional team led by scientists at the Indiana University School of Medicine have discovered an immune system gene associated with higher rates of amyloid plaque buildup in the brains of Alzheimer's patients and older adults at risk for the disease.

6 Oct 2015

Body weight change in older women may aid in diagnosis, management of Alzheimer's disease

Researchers led by Deborah Gustafson, PhD, MS, professor of neurology at SUNY Downstate Medical Center, have shown that women with a gene variant (APOEe4 allele) associated with Alzheimer's disease experience a steeper decline in body mass index (BMI) after age 70 than those women without the version of the gene, whether they go on to develop dementia or not.

6 Oct 2015

Genetic polymorphisms may serve as prognostic markers for lung cancer

Genetic polymorphisms associated with cancer progression lead to variations in gene expression and may serve as prognostic markers for lung cancer. Researchers at the Hiroshima University and Saitama Medical University found that in patients with lung cancer, a single nucleotide polymorphism (SNP) may regulate gene and protein expression and be associated with poor prognosis.

6 Oct 2015

Researchers identify new gene locus that may protect children from developing malaria in Africa

Published today in Nature, the findings detail a new gene locus that can explain why, in communities where everyone is constantly exposed to malaria, some children develop severe malaria and others don't. Now, researchers can be sure that this particular stretch of our DNA plays a crucial role in the progression of the disease.

1 Oct 2015

Comprehensive collection of human genomic variants now available in Kaviar database

The Institute for Systems Biology (ISB) and the Inova Translational Medicine Institute (ITMI) announced today a new release of Kaviar, the most comprehensive collection of human genomic variants currently available to the public.

26 Sep 2015

Allele News and Research

Genetics play vital role in knee pain sensitivity

Small differences in specific genetic variant could alter nicotine consumption

Working Group identifies many potential genetic contributors to weight loss

Perceived stress increases likelihood of amnestic mild cognitive impairment in older people

Mayo Clinic investigators discover novel mechanism linked to diabetes risk

Baylor Miraca Genetics Laboratories licenses SNP probe technology from OGT

Perisylvian polymicrogyria gene found

APOE ε4 predicts risk of future depression

Single gene variation may influence obesity in children, adults

Changes in lifestyle could reduce Alzheimer's disease risk

Findings suggest a potential "early warning" detection system for Alzheimer's disease

Researchers use cutting edge genomic methods to explain protective effects of malaria vaccine candidate

ToMMo constructs Japanese population reference panel from genome information of 1,070 individuals

Quest Diagnostics scientists demonstrate new molecular combing technique that predicts cystic fibrosis, muscular dystrophy

Cardiac monitoring predicts survival in patients with Friedreich ataxia

IU-led scientists discover new gene that increases Alzheimer's disease risk

Body weight change in older women may aid in diagnosis, management of Alzheimer's disease

Genetic polymorphisms may serve as prognostic markers for lung cancer

Researchers identify new gene locus that may protect children from developing malaria in Africa

Comprehensive collection of human genomic variants now available in Kaviar database

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

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