Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Researchers use electric fields to identify aged cells

Researchers from Tokyo Metropolitan University have created a new way of telling "aged" human cells apart from younger ones using electric fields.

21 Jun 2025

Study reveals intercellular flow as crucial factor in tissue mechanics

Water makes up around 60 percent of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.

21 Jun 2025

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

A recent study published in Engineering has provided novel insights into the involvement of α2,6-sialylation in Alzheimer's disease (AD), revealing that the ablation of α2,6-sialyltransferase-I (ST6Gal-I), an enzyme responsible for α2,6-sialylation, can downregulate BACE1 expression and suppress the production of amyloid-β42 (Aβ42) plaques, which are hallmarks of AD.

20 Jun 2025

New 3D immunohistochemistry method enhances deep tissue imaging

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

19 Jun 2025

Why Alzheimer’s DNA tests don’t treat all populations equally

A major global study tested whether European-derived polygenic risk scores (PGS) for Alzheimer’s disease can predict risk across diverse populations. While PGS performed well in many groups, it was less accurate in individuals of sub-Saharan African and Indian ancestry, highlighting the urgent need for more inclusive genetic data.

19 Jun 2025

Study finds high levels of iron in the brains of people diagnosed with Down syndrome and Alzheimer's

Scientists at the USC Leonard Davis School of Gerontology have discovered a key connection between high levels of iron in the brain and increased cell damage in people who have both Down syndrome and Alzheimer's disease.

19 Jun 2025

Researchers identify key differences in Alzheimer's progression in humans and animal models

Although it is known that Alzheimer's disease can start up to 20 years before the first symptoms appear, the lack of knowledge about how it progresses prevents the development of effective treatments, as well as a clear diagnosis to confront this neurodegenerative disease, which origin is also unknown.

19 Jun 2025

Brain age gap may influence the relationship between cognitive impairment risk factors

The difference between the brain's predicted age and actual chronological age, called a brain age gap, may influence the relationship between cognitive impairment risk factors, like high blood pressure and diabetes, and a person's cognitive performance, also known as thinking and memory skills, according to a study published June 18, 2025, in Neurology, the medical journal of the American Academy of Neurology.

19 Jun 2025

Could a diabetes drug be the key to stopping Alzheimer’s?

Investigating tirzepatide's role in Alzheimer's reveals its potential to improve brain function and reduce inflammation, linking diabetes and neurodegeneration.

17 Jun 2025

Indiana University researcher helps develop FDA-approved Alzheimer’s test

A first-of-its-kind blood test to detect amyloid plaques in the brain associated with Alzheimer's disease recently received clearance from the U.S. Food and Drug Administration. An Indiana University School of Medicine researcher who helped lead the discovery and development of one of the biomarkers the test identifies hopes it will provide greater access and a more accurate diagnosis for patients.

16 Jun 2025

c-Fos exhibits a dual role in memory formation and Alzheimer's disease

Immediate-early genes (IEGs), including c-Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural activity, synaptic plasticity, and stress responses.

14 Jun 2025

UK study finds small proportion of early Alzheimer’s patients suitable for latest treatments

Few people in the UK with early stage Alzheimer's disease are likely to be suitable for the latest drugs which aim to halt progress of the condition, yet many are nevertheless likely to be referred for these treatments, finds research published online in the Journal of Neurology Neurosurgery & Psychiatry.

13 Jun 2025

APOE gene variants influence metabolic patterns linked to aging and Alzheimer’s risk

A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled "APOE genotype and biological age impact inter-omic associations related to bioenergetics."

12 Jun 2025

Engineered lymph node model advances human immune system research

Scientists with the Fralin Biomedical Research Institute at VTC have created an engineered model of the supportive tissue found within a lymph node to study human health.

12 Jun 2025

Exercise targets specific brain cells to protect against Alzheimer’s

Using advanced single-nuclei RNA sequencing (snRNA-seq) and a widely used preclinical model for Alzheimer's disease, researchers from Mass General Brigham and collaborators at SUNY Upstate Medical University have identified specific brain cell types that responded most to exercise.

12 Jun 2025

New large-scale study maps early triggers of Alzheimer’s protein aggregation

A new large-scale study has mapped the first molecular events that drive the formation of harmful amyloid protein aggregates found in Alzheimer's disease, pointing towards a new potential therapeutic target.

12 Jun 2025

Legal environment shapes doctors’ preferences for assisted dying

When it comes to advanced cancer or Alzheimer's disease, over half of doctors would consider assisted dying for themselves, but preferences seem to vary according to their jurisdiction's legislation on euthanasia, reveal the results of an international survey, published online in the Journal of Medical Ethics.

11 Jun 2025

As federal health grants shrink, memory cafes help dementia patients and their caregivers

Rob Kennedy mingled with about a dozen other people in a community space in Clarks Summit, Pennsylvania.

10 Jun 2025

Brain-computer interfaces signal a new era in neurosurgery and neurorehabilitation

Brain-computer interface (BCI) technology is opening an unprecedented chapter in human-machine integration by establishing direct communication between the brain and external devices.

10 Jun 2025

‘We dissent’: NIH workers protest Trump policies that ‘harm the health of Americans’

Hundreds of workers at the National Institutes of Health on Monday openly protested the Trump administration’s cuts to the agency and consequences for human lives, writing in a sharply worded letter that its actions are causing "a dramatic reduction in life-saving research."

9 Jun 2025

Alzheimer's Disease News and Research

Further Reading

Researchers use electric fields to identify aged cells

Study reveals intercellular flow as crucial factor in tissue mechanics

Targeting ST6Gal-I shows promise in reducing Alzheimer’s disease pathology

New 3D immunohistochemistry method enhances deep tissue imaging

Why Alzheimer’s DNA tests don’t treat all populations equally

Study finds high levels of iron in the brains of people diagnosed with Down syndrome and Alzheimer's

Researchers identify key differences in Alzheimer's progression in humans and animal models

Brain age gap may influence the relationship between cognitive impairment risk factors

Could a diabetes drug be the key to stopping Alzheimer’s?

Indiana University researcher helps develop FDA-approved Alzheimer’s test

c-Fos exhibits a dual role in memory formation and Alzheimer's disease

UK study finds small proportion of early Alzheimer’s patients suitable for latest treatments

APOE gene variants influence metabolic patterns linked to aging and Alzheimer’s risk

Engineered lymph node model advances human immune system research

Exercise targets specific brain cells to protect against Alzheimer’s

New large-scale study maps early triggers of Alzheimer’s protein aggregation

Legal environment shapes doctors’ preferences for assisted dying

As federal health grants shrink, memory cafes help dementia patients and their caregivers

Brain-computer interfaces signal a new era in neurosurgery and neurorehabilitation

‘We dissent’: NIH workers protest Trump policies that ‘harm the health of Americans’

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