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Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

14 Nov 2024

Healthy low-carb diet and time-restricted eating improve weight loss and gut health beyond calorie restriction

Researchers discovered that a healthy low-carb diet and time-restricted eating, combined with moderate calorie restriction, offer significant weight loss and gut health benefits for overweight adults, with some effects lasting up to 28 weeks post-intervention.

13 Nov 2024

Utilizing process Raman in optimizing cultivated meat production

Learn about the usage of process raman spectroscopy in the optimization of bioreactor monitoring and then improvement of cultivated meat production.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 13 Nov 2024

Novel compound BHB-Phe could offer new approach to weight loss

Researchers at Baylor College of Medicine, Stanford University School of Medicine and collaborating institutions report in the journal Cell the discovery of BHB-Phe, a novel compound produced by the body that regulates appetite and body weight through interactions with neurons in the brain.

12 Nov 2024

Studies link gut dysbiosis to pancreatic cancer, offering pathways for early detection

The gut microbiome's impact on pancreatic cancer highlights potential for early screening and fecal microbiota transplantation in improving treatment efficacy.

11 Nov 2024

New approach reinvigorates exhausted T cells to improve tumor control

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells - which have lost their cancer-fighting oomph - consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

8 Nov 2024

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function in patients with pre-existing chronic liver disease.

8 Nov 2024

Understanding gut microbial imbalance in pancreatic cancer development and treatment

Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most lethal cancers, with an estimated five-year survival rate of approximately 10%.

7 Nov 2024

Ketogenic diet linked to gut microbes and seizure reduction in epileptic children

The ketogenic diet's anti-seizure effects in children may be influenced by gut bacteria and metabolites, highlighting their role in epilepsy treatment.

7 Nov 2024

UT Dallas researchers awarded $3.7 million NIH grant for brain aging study

Two researchers from The University of Texas at Dallas' Center for Vital Longevity (CVL) have received a five-year grant from the National Institutes of Health (NIH) to expand their study of brain structure, function and cognition across time through the use of powerful high-resolution imaging.

4 Nov 2024

New insights into early Huntington's disease mechanisms

Researchers uncover a link between impaired glutathione–ascorbate metabolism and early dopamine increases in Huntington's disease, suggesting GSTO2 as a potential therapeutic target to manage motor dysfunction.

4 Nov 2024

New study links childhood BMI trajectories to adult lung health

Researchers examine interactions between early life body mass index values and later life lung function.

1 Nov 2024

Study compares metabolism of humantenirine in human, pig, and goat liver microsomes

Gelsemium elegans Benth (G. elegans) is a traditional medicinal plant; however, it is highly toxic, and toxicity varies significantly between species.

30 Oct 2024

Machine learning reveals secrets of aging in flies and humans

Discoveries that impact lifespan and healthspan in fruit flies are usually tested in mice before being considered potentially relevant in humans, a process that is expensive and time intensive. A pioneering approach taken at the Buck Institute leapfrogs over that standard methodology.

30 Oct 2024

Researchers identify genetic markers for cardiovascular disease

A team of researchers from Girona Biomedical Research Institute Dr. Josep Trueta (IDIBGI), Bellvitge Biomedical Research Institute (IDIBELL), IRB Barcelona, Institut Català d'Oncologia (ICO), Germans Trias i Pujol Research Institute (IGTP) has worked together to identify possible genes associated with certain metabolites - molecules involved in the body's biochemical processes - and cardiovascular risk.

30 Oct 2024

Enzyme from gut microbe shows promise in fighting childhood malnutrition

The study highlights FAAH's role in gut microbiota, showing its potential in improving growth and health in malnourished children through dietary intervention.

29 Oct 2024

Abnormal BMI in children linked to impaired lung function

An abnormal BMI in children - be it high or low - can now be associated with impaired lung function, but if their BMI is normalized before they reach adulthood, the impairment can be offset, researchers from Karolinska Institutet report.

28 Oct 2024

Physical tests offer prognostic insights for lung cancer patients

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing and walking can help physicians arrive at a prognosis and approach to treatment.

22 Oct 2024

New research reveals GPR31's role in immune response to gut infections

Researchers from Osaka University discover that the GPR31 path in 'gut surveillance' cells detects bacterial metabolites and triggers immune responses, opening new possibilities for drug development, vaccines, and probiotics to fight infections.

22 Oct 2024

Frequent ultra-processed food consumption raises mortality risks, especially in women

Ultra-processed food intake is linked to increased all-cause and cause-specific mortality, particularly in females, with metabolomic signatures highlighting the associated risks. This study provides critical evidence on the health dangers of UPFs.

22 Oct 2024

Metabolites News and Research

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

Healthy low-carb diet and time-restricted eating improve weight loss and gut health beyond calorie restriction

Utilizing process Raman in optimizing cultivated meat production

Novel compound BHB-Phe could offer new approach to weight loss

Studies link gut dysbiosis to pancreatic cancer, offering pathways for early detection

New approach reinvigorates exhausted T cells to improve tumor control

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Understanding gut microbial imbalance in pancreatic cancer development and treatment

Ketogenic diet linked to gut microbes and seizure reduction in epileptic children

UT Dallas researchers awarded $3.7 million NIH grant for brain aging study

New insights into early Huntington's disease mechanisms

New study links childhood BMI trajectories to adult lung health

Study compares metabolism of humantenirine in human, pig, and goat liver microsomes

Machine learning reveals secrets of aging in flies and humans

Researchers identify genetic markers for cardiovascular disease

Enzyme from gut microbe shows promise in fighting childhood malnutrition

Abnormal BMI in children linked to impaired lung function

Physical tests offer prognostic insights for lung cancer patients

New research reveals GPR31's role in immune response to gut infections

Frequent ultra-processed food consumption raises mortality risks, especially in women

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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