Small Molecules News and Research

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Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers at The Wistar Institute have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer.

27 Jan 2021

Researchers discover potent antifungal agent from attine ant farms

Attine ants are farmers, and they grow fungus as food. Pseudonocardia and Streptomyces bacteria are their farmhands, producing metabolites that protect the crop from pathogens.

20 Jan 2021

Newly discovered biochemical pathway can protect cells from ferroptosis

The hallmarks of cancer include rapid cell-reproduction and metabolic activity. But these processes also lead to increased cellular stress and oxidation, and the risk of cell death.

15 Jan 2021

Scientists discover genetic variations that have a drastic impact on small molecules

The human organism requires a variety of small molecules, such as sugars or fats, in order to function properly.

14 Jan 2021

New findings could help better understand the mechanisms underlying severe malaria

The levels of small molecules called microRNAs (miRNAs) circulating in blood could help identify early on children with life-threatening forms of malaria, according to a study led by the Barcelona Institute for Global Health, an institution supported by "la Caixa" Foundation, in collaboration with the Manhiça Health Research Center (CISM) in Mozambique.

13 Jan 2021

Metabolites may be predictive indicators of patients at risk for recurrent major depression

Researchers at University of California San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites - small molecules produced by the process of metabolism - may be predictive indicators for persons at risk for recurrent major depressive disorder.

12 Jan 2021

Freiburg researchers receive ERC funding to develop and test immunostimulatory drug candidates

With the Proof of Concept funding line, the ERC grants recipients of ERC frontier research funds (Starting, Consolidator, Advanced or Synergy grants) with 150.000 Euro to develop promising ideas with commercial or societal potential to the proof of concept stage.

11 Jan 2021

Trinity researchers discover key mechanism underlying bacterial skin colonization in atopic dermatitis

Researchers from Trinity College Dublin have discovered a key mechanism underlying bacterial skin colonization in atopic dermatitis, which affects millions around the globe.

11 Jan 2021

Researchers receive NIH grant to develop more effective flu vaccines

To build better vaccines, scientists want to know more about how our bodies make adequate numbers of effective, durable antibodies against the influenza virus.

11 Jan 2021

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

An interesting new study published on the bioRxiv preprint server describes a new platform that allows a high-throughput workflow to generate matched human lung buds in the tens of thousands. This allows researchers to study SARS-CoV-2 infection and therapeutics in lung tissue that mirrors the key aspects of human lung development.

10 Jan 2021

Researchers pinpoint spike protein regions as targets for passive and active COVID-19 vaccines

Researchers at Stanford University School of Medicine have identified regions of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have relatively few mutations and might therefore serve as important targets for prophylactic agents against coronavirus disease 2019 (COVID-19).

10 Jan 2021

New cell therapy can boost immunotherapy against breast cancer

Boosting immune system T cells to effectively attack solid tumors, such as breast cancers, can be done by adding a small molecule to a treatment procedure called chimeric antigen receptor-T (CAR-T) cell therapy, according to a study by researchers at the UNC Lineberger Comprehensive Cancer Center.

4 Jan 2021

Researchers identify new weapon to battle the rising tide of antibiotic-resistant bacteria

As scientists around the globe wage war against a novel, deadly virus, one University of Colorado Boulder lab is working on new weapons to battle a different microbial threat: a rising tide of antibiotic-resistant bacteria which, if left unchecked, could kill an estimated 10 million people annually by 2050.

23 Dec 2020

The weak spot of colon cancer stem cells

Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body.

21 Dec 2020

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

As the coronavirus disease 2019 (COVID-19) pandemic continues to intensify in many parts of the world, vaccine development is proceeding apace.

21 Dec 2020

MFCR awards new grants to support an emerging approach to cancer therapeutics

The Mark Foundation for Cancer Research has awarded five new grants in support of an important, emerging approach to cancer therapeutics.

17 Dec 2020

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

For a vaccine to be most effective, sometimes nature needs a little 'extra' something. That something is often an adjuvant -- small molecules added to a vaccine that boost the body's immune response.

17 Dec 2020

Mogrify solidifies IP position surrounding core technology and expands platform algorithm to enhance cell conversion

Mogrify today announced it had secured the assignment of the foundational intellectual property underpinning its core direct cell conversion technology.

17 Dec 2020

New combination therapy has potential to treat aggressive cancers with common mutations

Scientists have long known that therapies that target the cancer-driving MAPK pathway are only effective in a handful of cancers with specific mutations in a cancer gene called BRAF, and these cancers that initially respond to the therapy often end up developing resistance to the treatment, resulting in relapse for many patients.

14 Dec 2020

Healthy gut microbiota contributes to normal brain function, study shows

Depression is a mental disorder that affects more than 264 million people of all ages worldwide. Understanding its mechanisms is vital for the development of effective therapeutic strategies.

11 Dec 2020

Small Molecules News and Research

Wistar researchers discover new enzymatic function of the Epstein-Barr Virus protein

Researchers discover potent antifungal agent from attine ant farms

Newly discovered biochemical pathway can protect cells from ferroptosis

Scientists discover genetic variations that have a drastic impact on small molecules

New findings could help better understand the mechanisms underlying severe malaria

Metabolites may be predictive indicators of patients at risk for recurrent major depression

Freiburg researchers receive ERC funding to develop and test immunostimulatory drug candidates

Trinity researchers discover key mechanism underlying bacterial skin colonization in atopic dermatitis

Researchers receive NIH grant to develop more effective flu vaccines

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

Researchers pinpoint spike protein regions as targets for passive and active COVID-19 vaccines

New cell therapy can boost immunotherapy against breast cancer

Researchers identify new weapon to battle the rising tide of antibiotic-resistant bacteria

The weak spot of colon cancer stem cells

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

MFCR awards new grants to support an emerging approach to cancer therapeutics

PVP at Boston Children's awarded $1 million to extend research into adjuvant-based vaccines

Mogrify solidifies IP position surrounding core technology and expands platform algorithm to enhance cell conversion

New combination therapy has potential to treat aggressive cancers with common mutations

Healthy gut microbiota contributes to normal brain function, study shows

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