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RNA Targeted Small Molecules: Finally Drug the “Undruggable” RNA

At a time when the previously untapped drug discovery opportunity promised within RNA opens up, the 2nd RNA- Targeted Drug Discovery Summit returns to reunite the leading minds from large pharma, innovative biotech and KOLs of academia to overcome unique discovery and development challenges associated with novel RNA targeted small molecule therapeutics and achieve their seemingly limitless potential.

From RNA-Targeted Drug Discovery Summit 30 Sep 2019

US Government supports Kinoxis Therapeutics to end opioid addiction

Kinoxis Therapeutics has been awarded a grant for a potential of up to $US4.6 million ($6.8 million) under the USA National Institutes of Health Helping to End Addiction Long-Term, or the NIH HEAL Initiative.

30 Sep 2019

Additional heart artery stenting can help prevent future heart attacks

Research has shown that patients who have had emergency heart attack treatment with heart artery stenting - and have significant narrowings in their other untreated arteries - can benefit from additional stenting to help prevent future heart attacks.

28 Sep 2019

NAU researchers aim to find microbial link between two common respiratory diseases

Asthma and chronic rhinosinusitis- sinus inflammation that lasts for at least three months- are serious and costly diseases, and both are on the rise. According to the American Academy of Allergy, Asthma and Immunology, CRS affects up to 16 percent of the U.S. adult population and eats up a staggering 5 percent of the country's health care budget each year.

27 Sep 2019

Novel nanogels could precisely deliver therapeutic treatments to cancer patients

Researchers at The University of Texas at Austin have developed new guidelines for fabricating nanoscale gel materials, or nanogels, that can deliver numerous therapeutic treatments to treat cancer in a precise manner.

27 Sep 2019

Polymer drug-eluting and polymer-free drug-coated stents safe and effective for patients with high bleeding risk

The first randomized trial to compare a durable polymer drug-eluting stent to a polymer-free drug-coated stent in patients at high risk of bleeding and treated with one-month dual antiplatelet therapy (DAPT) found that both are clinically safe and effective.

27 Sep 2019

IDEAL LM study: Biodegradable polymer everolimus-eluting stent safe and effective for patients undergoing PCI

New data from the IDEAL-LM trial found that a biodegradable polymer everolimus-eluting stent (BP-EES) followed by four months of dual antiplatelet therapy (DAPT) was safe and effective compared to a conventional durable polymer everolimus-eluting stent (DP-EES) followed by 12 months of DAPT in patients undergoing PCI for unprotected left main coronary artery (uLMCA) disease.

27 Sep 2019

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

New data from the randomized, placebo-controlled TWILIGHT trial found that compared to ticagrelor plus aspirin, ticagrelor monotherapy reduces bleeding events without increasing the risk of death, myocardial infarction, or stroke in high-risk patients who have undergone successful percutaneous coronary intervention and completed three months of dual antiplatelet therapy.

27 Sep 2019

Shorter duration DAPT after PCI did not increase adverse events in high-bleeding risk patients, finds study

Data from the EVOLVE Short DAPT study found that shortened three-month dual antiplatelet therapy did not increase myocardial infarction or stent thrombosis in high bleeding risk patients treated with a contemporary drug-eluting stent.

27 Sep 2019

Combination therapy may offer new therapeutic avenue for previously-treated NSCLC and kidney cancer patients

Pegilodecakin, a first-in-class drug currently in clinical trials, has shown positive safety results and may offer a potential new treatment avenue for patients with non-small cell lung cancer and kidney cancer.

26 Sep 2019

High-risk heart patients may not require long-term aspirin use after stent placement

High-risk patients undergoing coronary stent procedures may not require long-term aspirin use after stent placement, Mount Sinai researchers report in a groundbreaking study

26 Sep 2019

Children's of Alabama using cold sore virus to fight pediatric brain cancer

Children's of Alabama is home to one of the most exciting studies underway in pediatric cancer: evaluating the use of a cold sore virus to treat children with progressive malignant brain tumors.

26 Sep 2019

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

An international, multicenter phase II clinical trial is evaluating the efficacy and safety of mavrilimumab co-administered with a 26-week corticosteroid taper in patients with giant cell arteritis.

26 Sep 2019

Texas Biomed scientists continue testing therapies and vaccines for Ebola virus

In mid-August 2019, human clinical trials were halted in the current Ebola epidemic that has claimed more than 2,100 lives in Africa.

26 Sep 2019

New NIH program aims to improve lives for people with inherited blood and immune diseases

People with inherited diseases of the blood and immune system can now receive treatment at the National Institutes of Health Clinical Center through a new, streamlined program that integrates expertise from many medical specialties and related basic science disciplines.

26 Sep 2019

Research reveals molecular link between chronic pain and depression

Researchers at Hokkaido University have identified the brain mechanism linking chronic pain and depression in rats. Their research, which was recently published in The Journal of Neuroscience, could lead to the development of new treatments for chronic pain and depression.

26 Sep 2019

'A new era of drug discovery’: Company develops drug using AI

For the first time, a company has discovered a drug target and corresponding candidate using artificial intelligence (AI).

26 Sep 2019

Investigational drug may offer new treatment option for patients with lung and kidney cancer

26 Sep 2019

Scientists use new single-cell genetic technique to tackle potential drug resistance

Using a new technique that can identify genetic profiles of individual cells, University of Notre Dame researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance.

25 Sep 2019

Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

A metabolic imbalance in some cancer patients following treatment with a checkpoint inhibitor drug, nivolumab, is associated with resistance to the immunotherapy agent and shorter survival, report scientists from Dana-Farber Cancer Institute, in collaborative work with the Broad Institute of MIT and Harvard.

25 Sep 2019

Therapeutics News and Research

RNA Targeted Small Molecules: Finally Drug the “Undruggable” RNA

US Government supports Kinoxis Therapeutics to end opioid addiction

Additional heart artery stenting can help prevent future heart attacks

NAU researchers aim to find microbial link between two common respiratory diseases

Novel nanogels could precisely deliver therapeutic treatments to cancer patients

Polymer drug-eluting and polymer-free drug-coated stents safe and effective for patients with high bleeding risk

IDEAL LM study: Biodegradable polymer everolimus-eluting stent safe and effective for patients undergoing PCI

Ticagrelor monotherapy reduces bleeding while preserving ischemic benefit in high-risk PCI patients

Shorter duration DAPT after PCI did not increase adverse events in high-bleeding risk patients, finds study

Combination therapy may offer new therapeutic avenue for previously-treated NSCLC and kidney cancer patients

High-risk heart patients may not require long-term aspirin use after stent placement

Children's of Alabama using cold sore virus to fight pediatric brain cancer

Clinical trial to evaluate efficacy and safety of new treatment for giant cell arteritis

Texas Biomed scientists continue testing therapies and vaccines for Ebola virus

New NIH program aims to improve lives for people with inherited blood and immune diseases

Research reveals molecular link between chronic pain and depression

'A new era of drug discovery’: Company develops drug using AI

Investigational drug may offer new treatment option for patients with lung and kidney cancer

Scientists use new single-cell genetic technique to tackle potential drug resistance

Metabolic imbalance in cancer patients associated with resistance to immune checkpoint blocker

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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