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Two-arm molecule can deplete cancer-protecting cells to promote immune responses against tumors

A two-arm molecule can effectively deplete cancer-protecting cells inside tumors, allowing the immune system to fight off tumors without becoming overactive. The finding, published online in Science Translational Medicine, could lead to new types of cancer immunotherapies.

11 Aug 2021

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

Cancer cells have evolved a myriad of mechanisms that support their uncontrolled growth. In case of solid tissue tumors, the tumor microenvironment, which consists of extracellular components and conditions surrounding the tumor, is crucial in deciding the fate of the cancer cells.

11 Aug 2021

UC Davis epidemiologist turns to colleagues for cancer care

Brad Pollock knows a lot about cancer. In addition to his appointments as chair of the UC Davis Public Health Sciences Department and associate dean for public health sciences, Pollock is an expert in cancer epidemiology, including the study of what causes cancer, how it spreads and cancer prevention.

11 Aug 2021

Deep learning model can classify intracranial tumors using a single 3D MRI scan

A team of researchers at Washington University School of Medicine have developed a deep learning model that is capable of classifying a brain tumor as one of six common types using a single 3D MRI scan, according to a study published in Radiology: Artificial Intelligence.

11 Aug 2021

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

A potential new treatment for mast cell cancers reduces the number of mast cells by "mutating" the messenger RNA (mRNA) before it can deliver instructions for manufacturing the gene responsible for cell proliferation.

10 Aug 2021

New approach could be a useful tool in the fight against cancer drug resistance

Using a virus to purposely mutate genes that produce cancer-driving proteins could shed light on the resistance that inevitably develops to cancer drugs that target them, a new study led by UT Southwestern scientists suggests.

10 Aug 2021

Study may provide a new therapeutic target for treatment of LUAD patients

Aging-US published "A novel ferroptosis-related gene signature for prognostic prediction of patients with lung adenocarcinoma" which reported that RNA-seq transcriptome data of LUAD patients were obtained from The Cancer Genome Atlas database.

9 Aug 2021

New recommendations for diagnosis and treatment of brain metastases from solid tumors

Brain metastases are a common and dangerous complication in cancer patients. Under the leadership of experts from MedUni Vienna, two of the largest international oncology societies have published new clinical guidelines for the diagnosis and treatment of brain metastases from solid tumors.

9 Aug 2021

MRI texture features can predict response to neoadjuvant chemotherapy in patients with breast cancer

Oncotarget published "MRI texture features from tumor core and margin in the prediction of response to neoadjuvant chemotherapy in patients with locally advanced breast cancer" which reported that the authors investigated whether pre-treatment T2-weighted magnetic resonance imaging can be used to predict response to neoadjuvant chemotherapy in breast cancer.

6 Aug 2021

New immunotherapy strategy can eliminate pancreatic tumors in mice

Pancreatic cancer, which affects about 60,000 Americans every year, is one of the deadliest forms of cancer. After diagnosis, fewer than 10 percent of patients survive for five years.

6 Aug 2021

Scientists use AI to identify new biomarkers for breast cancer

Scientists at Case Western Reserve University have used Artificial Intelligence (AI) to identify new biomarkers for breast cancer that can predict whether the cancer will return after treatment - and which can be identified from routinely acquired tissue biopsy samples of early-stage breast cancer.

6 Aug 2021

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Remetinostat, a topical cream and first-in-class inhibitor of histone deacetylation, showed signs of clinical efficacy in patients with basal cell carcinoma.

6 Aug 2021

Using circulating tumor DNA to detect urothelial cancer relapse could help improve treatment

Using circulating tumor DNA to identify patients at risk of urothelial cancer relapse after surgical resection could help improve post-surgery treatment.

6 Aug 2021

Researchers create new model for studying earliest stages of retinoblastoma

Scientists at St. JudeChildren's Research Hospital have created a laboratory model for studying retinoblastoma driven by inherited mutations in theRB1gene.Retinoblastoma is a rare cancer of the retina, the thin tissue inside the back of the eye.

6 Aug 2021

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Immunohistochemistry staining showing PD1 expression on tumor cells in a skin biopsy from a cutaneous T-cell lymphoma patient.

5 Aug 2021

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

A new study has revealed the mechanism by which the SARS-CoV-2 N protein activates NLRP3 inflammasomes to induce hyperinflammation.

5 Aug 2021

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Shuo Ma, MD, '00 PhD, associate professor of Medicine in the Division of Hematology and Oncology, was co-first author of the clinical trial published in Blood.

5 Aug 2021

Research suggests potential new treatment strategy for phenylketonuria

Researchers at The University of Texas MD Anderson Cancer Center have discovered a critical new factor in regulating phenylalanine metabolism and, therefore, in preventing the inherited metabolic disorder phenylketonuria (PKU).

5 Aug 2021

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Lung cancer remains the leading cause of cancer-associated death in the United States and worldwide. Patients with a subtype called lung adenocarcinoma (LUAD) have benefited from the development of new targeted medicines, but the search for effective new therapies for another subtype called lung squamous cell carcinoma (LSCC) has largely come up short.

5 Aug 2021

Experimental drug combination extends survival in mice with lung cancer, study finds

A combination of experimental drugs increased the attack of immune cells on non-small cell lung cancer (NSCLC) to extend survival in mice, a new study found.

5 Aug 2021

Tumor News and Research

Two-arm molecule can deplete cancer-protecting cells to promote immune responses against tumors

Understanding hypoxia-induced gene expression variations in aggressive type of pancreatic cancer

UC Davis epidemiologist turns to colleagues for cancer care

Deep learning model can classify intracranial tumors using a single 3D MRI scan

Potential new treatment for mast cell cancers reduces tumor size and prevents organ infiltration

New approach could be a useful tool in the fight against cancer drug resistance

Study may provide a new therapeutic target for treatment of LUAD patients

New recommendations for diagnosis and treatment of brain metastases from solid tumors

MRI texture features can predict response to neoadjuvant chemotherapy in patients with breast cancer

New immunotherapy strategy can eliminate pancreatic tumors in mice

Scientists use AI to identify new biomarkers for breast cancer

Topical cream shows signs of clinical efficacy in patients with basal cell carcinoma

Using circulating tumor DNA to detect urothelial cancer relapse could help improve treatment

Researchers create new model for studying earliest stages of retinoblastoma

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

Combination therapy improves outcomes for relapsed chronic lymphocytic leukemia

Research suggests potential new treatment strategy for phenylketonuria

Researchers develop the most comprehensive molecular map of lung squamous cell carcinoma

Experimental drug combination extends survival in mice with lung cancer, study finds

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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