immunity News and Research

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D614G mutation now the dominant variant in the global COVID-19 pandemic

Now, a new study published on the preprint server medRxiv in September 2020 shows that a significant variant characterized by the D614G mutation has higher infectivity, which may account for its rapid rise to the dominant position in all regions where it has emerged.

25 Sep 2020

About 10% patients with severe disease create auto-antibodies that attack the immune system

People infected by the novel coronavirus can have symptoms that range from mild to deadly. Now, two new analyses suggest that some life-threatening cases can be traced to weak spots in patients' immune systems.

25 Sep 2020

Faulty genes and an autoimmune condition linked to severe COVID-19 in young, healthy people

More than 10 percent of young and healthy people who develop severe COVID-19 have misguided antibodies that attack not the virus, but the immune system itself, new research shows. Another 3.5 percent, at least, carry a specific kind of genetic mutation.

25 Sep 2020

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Two new studies report specific mechanisms of impaired type I interferon (IFN) signaling in some hospitalized patients suffering from severe cases of COVID-19, suggesting that screens for these defects could help identify patients at the highest risk of life-threatening complications from SARS-CoV-2 infection.

25 Sep 2020

Scientists to use CRISPR gene-editing technology for Phase 1 vaccine trials in humans

Scientists are planning for Phase 1 human trials of a vaccine they developed by using CRISPR gene-editing technology to mutate the parasite that causes leishmaniasis, a skin disease common in tropical regions of the world and gaining ground in the United States

25 Sep 2020

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

Individuals with severe forms of COVID-19 disease can present with compromised type I interferon (IFN) responses based on their genetics, according to results published in two papers today in the journal Science.

25 Sep 2020

New study may explain why more men than women die from COVID-19

New findings by scientists at the National Institutes of Health and their collaborators help explain why some people with COVID-19 develop severe disease.

25 Sep 2020

New antibodies protect mice against lethal infections of influenza B virus

Researchers have identified two antibodies that protect mice against lethal infections of influenza B virus, report scientists at Washington University School of Medicine in St. Louis and Icahn School of Medicine at Mount Sinai.

24 Sep 2020

Tokyo citizens may have developed COVID-19 herd immunity, say researchers

Researchers in Japan and the United States have conducted a study showing that herd immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have developed among the citizens of Tokyo during the summer.

24 Sep 2020

Brazil becomes global hotspot for COVID-19 pandemic

Two nationwide COVID-19 antibody seroprevalence studies from Brazil show that many cities along the Amazon were hit hardest at the beginning of the epidemic in May and June, along with poorer and Indigenous communities.

24 Sep 2020

FDA issues emergency use authorization for first serology point-of-care test for COVID-19

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the first serology (antibody) point-of-care (POC) test for COVID-19.

24 Sep 2020

Siemens’ SARS-CoV-2 antibody immunoassays meet regulatory targets

New research being presented at the ESCMID Conference on Coronavirus Disease (ECCVID, online 23-25 September) shows that, in a head-to-head comparison of five tests used to detect SARS-CoV-2 antibodies (known as 'immunoassays'), an assay manufactured by Siemens and one developed by an academic partnership led by the University of Oxford had the most accurate results.

24 Sep 2020

Fourth Phase 3 clinical trial evaluating COVID-19 vaccine begins in the U.S.

A fourth Phase 3 clinical trial evaluating an investigational vaccine for coronavirus disease 2019 (COVID-19) has begun enrolling adult volunteers.

23 Sep 2020

New T-cell-based vaccine strategy provides broader protection against seasonal influenza

As Americans begin pulling up their sleeves for an annual flu vaccine, researchers at the University of Wisconsin-Madison have provided new insights into an alternative vaccine approach that provides broader protection against seasonal influenza.

23 Sep 2020

HIV drugs cause immune-system changes that can improve resistance to viral infections

Drugs currently used to keep the HIV virus in check also cause immune-system changes that might make humans better able to resist viral infections – but might also cause harmful inflammation, according to a study published today in Cell Reports Medicine.

23 Sep 2020

Shielding strategy could be ineffective in reducing COVID-19 prevalence and mortality

With the recognition that certain subgroups of the population seemed to have a higher risk of developing severe disease following infection, some countries put shielding policies into place to protect them from infection.

23 Sep 2020

A subunit SARS-CoV-2 vaccine may offer broader protection against virus

A new study published in the preprint server bioRxiv in September 2020 reports on the structure of this protein, as revealed by cryo-electron microscopy (cryoEM).

23 Sep 2020

Study suggests herd immunity to COVID-19 in Brazilian city of Manaus

According to the study estimates, the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes COVID-19 – rapidly increased in Manaus between March and April, before slowly declining between May and September.

22 Sep 2020

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

In a recent bioRxiv preprint paper, researchers from the Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR, and Department of Global Health, University of Washington, Seattle, WA, discuss their study in mice that undergo detailed immunophenotyping before getting infected with SARS-CoV.

22 Sep 2020

Confirmed early re-infection with SARS-CoV-2

As scientists strive to develop commercially viable and effective antivirals and vaccines to counter the growing COVID-19 pandemic, there is considerable uncertainty about how long and how durable the immunity induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is. A new paper recently published in the journal Clinical Infectious Disease in September 2020 reports a confirmed case of re-infection with this virus following recovery.

22 Sep 2020

immunity News and Research

D614G mutation now the dominant variant in the global COVID-19 pandemic

About 10% patients with severe disease create auto-antibodies that attack the immune system

Faulty genes and an autoimmune condition linked to severe COVID-19 in young, healthy people

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Scientists to use CRISPR gene-editing technology for Phase 1 vaccine trials in humans

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

New study may explain why more men than women die from COVID-19

New antibodies protect mice against lethal infections of influenza B virus

Tokyo citizens may have developed COVID-19 herd immunity, say researchers

Brazil becomes global hotspot for COVID-19 pandemic

FDA issues emergency use authorization for first serology point-of-care test for COVID-19

Siemens’ SARS-CoV-2 antibody immunoassays meet regulatory targets

Fourth Phase 3 clinical trial evaluating COVID-19 vaccine begins in the U.S.

New T-cell-based vaccine strategy provides broader protection against seasonal influenza

HIV drugs cause immune-system changes that can improve resistance to viral infections

Shielding strategy could be ineffective in reducing COVID-19 prevalence and mortality

A subunit SARS-CoV-2 vaccine may offer broader protection against virus

Study suggests herd immunity to COVID-19 in Brazilian city of Manaus

Baseline T cell signatures predict clinical outcomes of SARS-CoV infection

Confirmed early re-infection with SARS-CoV-2

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