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Inflammation in mid-life may be linked to brain shrinkage decades later

People who have biomarkers tied to inflammation in their blood in their 40s and 50s may have more brain shrinkage decades later than people without the biomarkers, according to a study published in the November 1, 2017, online issue of Neurology, the medical journal of the American Academy of Neurology. The brain cell loss was found especially in areas of the brain that are affected by Alzheimer's disease.

2 Nov 2017

New CAR-T cell therapy offers effective option for certain blood cancer patients

Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis is one of the first centers nationwide to offer a new immunotherapy that targets certain blood cancers.

19 Oct 2017

Higher level of tumor-infiltrating lymphocytes linked to better survival for ovarian cancer patients

A group of international cancer researchers led by investigators from Mayo Clinic and University of New South Wales Sydney has found that the level of a type of white blood cell, called tumor-infiltrating lymphocytes, present in the tumors of patients with high-grade ovarian cancer may predict a patient's survival.

12 Oct 2017

Researchers uncover enzyme behind immune cell response

Monash University researchers have revealed the role played by an enzyme that is pivotal to the process of clearing infection in the body.

12 Oct 2017

Calcium controls use of glucose by T cells to multiply and battle against infection, study finds

A calcium signal controls whether immune cells can use the nutrients needed to fuel their multiplication into a cellular army designed to fight invading viruses.

11 Oct 2017

FDA approves Verzenio for advanced metastatic breast cancer

The U.S. Food and Drug Administration (FDA) has approved a new drug Verzenio (abemaciclib) for the treatment of advanced or metastatic hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

2 Oct 2017

Penn researchers develop predictive model to help lung cancer patients avoid ED visits

A pilot program that uses big data to predict which lung cancer patients will require a trip to an emergency department successfully anticipated a third of all ED visits over a two-week trial period, and was further able to identify which patients were at high risk and low risk of requiring such care.

27 Sep 2017

Regeneration ability may lie with the body's innate immune system, study shows

The answer to regenerative medicine's most compelling question -- why some organisms can regenerate major body parts such as hearts and limbs while others, such as humans, cannot -- may lie with the body's innate immune system, according to a new study of heart regeneration in the axolotl, or Mexican salamander, an organism that takes the prize as nature's champion of regeneration.

21 Sep 2017

Researchers identify natural protective factor against chronic inflammation in diabetes patients

In type 2 diabetes, chronic inflammation drives cardiovascular disease, the leading cause of death among people with the condition. Researchers at Joslin Diabetes Center now have identified an unexpected natural protective factor that works against this inflammation.

20 Sep 2017

Modified blood thinner may be first promising method to prevent repercussions after TBI

A chemically modified version of the common blood thinner heparin may be the first promising method of preventing the harmful cascade of destruction to brain tissue that commonly follows traumatic brain injury (TBI), according to new research findings.

13 Sep 2017

Researchers set new delivery distance record for medical drones

Johns Hopkins researchers have set a new delivery distance record for medical drones, successfully transporting human blood samples across 161 miles of Arizona desert. Throughout the three-hour flight, they report, the on-board payload system maintained temperature control, ensuring the samples were viable for laboratory analysis after landing.

12 Sep 2017

Antibody therapy found effective in subgroup of patients with treatment-resistant COPD

An antibody treatment reduces the rate of flare-ups by nearly 20 percent in patients with a subgroup of treatment-resistant chronic obstructive pulmonary disease (COPD), according to the results of two large international trials presented today at the European Respiratory Society International Congress in Milan, Italy, and simultaneously published in the New England Journal of Medicine.

12 Sep 2017

FDA approves first cell-based gene therapy for use in the United States

The U.S. Food and Drug Administration issued a historic action today making the first gene therapy available in the United States, ushering in a new approach to the treatment of cancer and other serious and life-threatening diseases.

30 Aug 2017

FDA grants accelerated approval to new treatment for children with Chagas disease

The U.S. Food and Drug Administration today granted accelerated approval to benznidazole for use in children ages 2 to 12 years old with Chagas disease. It is the first treatment approved in the United States for the treatment of Chagas disease.

29 Aug 2017

UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical trial of a novel combination drug therapy for B-cell cancers.

26 Aug 2017

$FDA approval provides new, targeted treatment option for adults with relapsed or refractory B-cell ALL$

FDA approval provides new, targeted treatment option for adults with relapsed or refractory B-cell ALL

The U.S. Food and Drug Administration today approved Besponsa (inotuzumab ozogamicin) for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).

17 Aug 2017

Antibiotic use makes immune cells less effective in fighting infections

Adding another reason for doctors to avoid the overuse of antibiotics, new research shows that a reduction in the variety of microbes in the gut interferes with the immune system's ability to fight off disease.

17 Aug 2017

Researchers discover way to stop deadly fungus from spreading to the brain

Research led by the University of Birmingham has discovered a way to stop a deadly fungus from 'hijacking' the body's immune system and spreading to the brain.

16 Aug 2017

Congress revamps housing program to benefit areas where HIV is spreading

In a bipartisan push, Congress has restructured a federal program that provides housing assistance for people living with HIV to funnel more money into areas struggling to control the outbreak.

7 Aug 2017

Cord-blood-derived natural killer cells can be modified to destroy B-cell cancers

Immune cells with a general knack for recognizing and killing many types of infected or abnormal cells also can be engineered to hunt down cells with specific targets on them to treat cancer, researchers at The University of Texas MD Anderson Cancer Center report in the journal Leukemia.

13 Jul 2017