in vivo News and Research

RSS

New air-liquid interface method enhances hair follicle formation in skin organoids

For decades, creating human skin models with physiological relevance has been a persistent challenge in dermatological research.

22 Jan 2025

The science of silk fibroin and chitosan: Techniques for biomaterials analysis

An interview on how advanced techniques can be used to enhance silk fibroin and chitosan for drug delivery applications.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 21 Jan 2025

Manuka vs. Ohia Lehua honey: Study reveals key antioxidant differences and health benefits

Study compares the antioxidant properties of Manuka honey (MH) and Ohia Lehua honey (OLH), revealing that MH contains ten times more phenolic content, while OLH demonstrates superior in vivo antioxidant activity by reducing oxidative stress and enhancing antioxidant capacity.

19 Jan 2025

Exploring the role of EpCAM in early-stage hepatocellular carcinoma progression

Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors.

17 Jan 2025

RNA damage plays key role in sunburn reaction

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study by the University of Copenhagen and Nanyang Technological University, Singapore, reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

17 Jan 2025

New gene-editing treatment extends lifespan in mice with prion disease

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

15 Jan 2025

Pharmacokinetics of berberine and astragaloside IV in normal and diabetic rats

Announcing a new publication for Acta Materia Medica journal. The UPLC-QqQ-MS/MS method was established, validated, and used for the simultaneous detection of berberine (BBR), astragaloside IV (AST), and the main metabolites to demonstrate the comparative pharmacokinetics of BBR and AST in normal and T2DM rats.

15 Jan 2025

Gut microbes revealed as hidden drivers of aging and cellular decline

Gut microbiota-derived phenylacetylglutamine accelerates aging by driving cellular senescence through mitochondrial dysfunction and DNA damage, offering insights into therapeutic interventions for age-related decline.

14 Jan 2025

Sapio Sciences Announces Enhanced Capabilities for Chemistry, Immunogenicity, GMP and Molecular Biology

Sapio Sciences' Release 24.12 enhances lab informatics with improved GMP workflows and molecular biology features, driving efficiency and scientific discovery.

From Sapio Sciences 14 Jan 2025

COVID-19 vaccine developed by Brazilian researchers shows promise in mice

Studies conducted in mice have shown that the COVID-19 vaccine being developed by researchers at the University of São Paulo's Medical School (FM-USP) in Brazil is safe and efficacious.

13 Jan 2025

Short-chain fatty acids propionate and butyrate directly modify chromatin to regulate gene expression

Short-chain fatty acids influence gene regulation and chromatin accessibility, highlighting their role in colorectal cancer and normal cellular processes.

13 Jan 2025

Study finds certain H5N1 strains in cattle linked to milder human illness; other variants remain a concern

Study reveals that contemporary HPAI H5N1 viruses show reduced replication and immune activation in human lung organoids, potentially explaining milder disease in humans compared to historic strains.

13 Jan 2025

Developing and refining muscle atrophy models for drug discovery

With the intensification of global population aging, muscle atrophy, characterized by the loss of muscle mass and function, has become an important health issue affecting the elderly. Researchers have widely used various animal and cellular models to gain a deeper understanding of the pathophysiological mechanisms of muscle atrophy and develop effective treatment strategies.

9 Jan 2025

Could autophagy enhancement slow aging and combat Alzheimer's?

How cellular cleanup systems could hold the key to slowing aging and halting neurodegeneration.

9 Jan 2025

Targeting miR-4274 and PEX5 can help overcome radioresistance in colorectal cancer

Colorectal cancer (CRC) is a global health concern, and despite advances in radiotherapy, endogenous radioresistance in CRC patients remains a challenge.

9 Jan 2025

Bioactive compounds in coffee and tobacco may combat Parkinson’s disease

Tobacco and coffee contain bioactive compounds that may reduce Parkinson's disease risk by targeting key pathways such as MAO B inhibition, α-synuclein aggregation, and neuroinflammation.

7 Jan 2025

Researchers enhance longevity of neural implants with protective coating

Neural implants contain integrated circuits (ICs) — commonly called chips — built on silicon. These implants need to be small and flexible to mimic circumstances inside the human body.

7 Jan 2025

Heart attack recovery enhanced by human stem cell spheroids, study shows

In a large-animal model study, researchers have found that heart attack recovery is aided by injection of heart muscle cell spheroids derived from human induced pluripotent stem cells, or hiPSCs, that overexpress cyclin D2 and are knocked out for human leukocyte antigen classes I and II.

7 Jan 2025

Brazilian tree compound offers hope for visceral leishmaniasis treatment

A compound derived from Nectandra leucantha, a tree native to southern Brazil (local names canela-seca or canela-branca), has the potential to be used to treat visceral leishmaniasis, a neglected tropical disease associated with poverty, malnutrition, poor housing and lack of basic sanitation.

7 Jan 2025

Study finds microRNA target to combat breast cancer treatment resistance

A new University of Cincinnati Cancer Center study has identified a particular strand of microRNA as a promising new target for overcoming breast cancer treatment resistance and improving outcomes.

7 Jan 2025