Therapeutics News and Research

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Harnessing the power of skin microbiome to develop new therapeutics

As scientific researchers continue to investigate the complexities of the skin microbiome, our mission for the 2nd Microbiome Movement – Skin Health & Dermatology Summit is simple: Build a collaborative forum that unites forward thinking academic, dermatological & cosmetic researchers, and lay out the foundational framework around the unique scientific and translational challenges involved in developing and commercializing solutions that modify the skin microbiome to treat disease (therapeutics) or support overall skin health (cosmetics).

From The Microbiome Movement 19 Jun 2019

Novel approach of blocking inflammation before surgical procedure may prevent cancer recurrences

A growing body of evidence suggests that traditional cancer treatments can paradoxically promote new tumor growth.

19 Jun 2019

Researchers investigate why many cancer clinical trials fail to enroll enough patients

The increasing sophistication of cancer treatments threatens to outpace the ability of health care providers to enroll patients in clinical trials to test those therapies. That's a key finding by researchers in UT Southwestern's new Department of Population and Data Sciences.

18 Jun 2019

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

It's a feat three decades in the making: Harvard University chemists have achieved what a new paper calls a "landmark in drug discovery" with the total synthesis of halichondrin.

17 Jun 2019

Research paves way for new treatment to protect people from cardiovascular disease

New University of Alberta research is paving the way for the first medical treatment to help protect people from cardiovascular disease by boosting the body's natural defenses.

17 Jun 2019

Scientists create 'mini-brain' for studying sporadic Creutzfeldt-Jakob disease

National Institutes of Health scientists have used human skin cells to create what they believe is the first cerebral organoid system, or "mini-brain," for studying sporadic Creutzfeldt-Jakob disease.

16 Jun 2019

Novel insight could improve vaccines that protect pregnant women and newborns

A team led by Duke Health scientists has identified a cellular process that could lead to the development of safer and more effective vaccines that protect pregnant women as well as their newborns from dangerous infections.

16 Jun 2019

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

What's good for our bones may also help stop cancer cells that develop resistance to multiple chemotherapy drugs.

14 Jun 2019

Chemicals produced by gut microbiome could help identify children at risk of organ failure

Chemicals produced by healthy bacteria could be used to assess the health of the gut microbiome and help identify critically-ill children at greatest risk of organ failure, a study published in Critical Care Medicine has found.

14 Jun 2019

New small drug-targeting molecules may improve cancer treatment

Researchers from the University of Notre Dame have developed small drug-targeting molecules that may be hundreds to thousands of times more effective at delivering potent drugs to desired sites of disease, including cancer.

14 Jun 2019

UAB researchers awarded $2.3 million grant to study macrophage circadian rhythms in heart failure

Researchers at the University of Alabama at Birmingham have been awarded a four-year, $2.3 million grant from the National Heart, Lung and Blood Institute to study macrophage circadian rhythms in heart failure.

13 Jun 2019

Norovirus structures could help develop therapeutics to fight food-borne illness

Noroviruses are a leading cause of food-borne illness outbreaks, accounting for 58% of all outbreaks and cause 685 million cases worldwide each year. There is no effective therapeutic against them. Having knowledge of the intricate structure of the outer layer of noroviruses, the capsid, which allows the virus to attach to its human host, could help in vaccine development.

13 Jun 2019

Scientists identify potential target for Parkinson's treatment

An international research team led by scientists at the University of Alabama at Birmingham has identified a potential target for therapeutics that might help slow the progression of Parkinson's disease.

12 Jun 2019

Study: Underweight boys and overweight girls have increased risk of depression

The results of a large community-based study have shown that the probability of major depressive disorder in children and adolescents with high, low, or normal body mass index differs according to gender.

12 Jun 2019

Plant-derived siRNAs could bring a 'green revolution' in RNAi tools and therapeutics

"Green revolution" in the early 1950s, the extensive cultivation of Dwarf Rice solves the food problem in developing countries. At present, chronic infection with hepatitis B virus (HBV) has been a major public health problem.

11 Jun 2019

URMC biotech start-up receives funding to develop cell-based therapies for neurological disorders

Oscine Therapeutics, a new biotechnology company based on discoveries made and developed at the University of Rochester Medical Center has received a significant multi-year investment to support both research and development of cell-based therapies for neurological disorders.

11 Jun 2019

Promising methods for early detection and treatment of rheumatoid arthritis

Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that leads to significant health issues as well as high treatment costs. In this themed issue of Clinical Therapeutics, published by Elsevier, experts review multiple aspects of RA detection and intervention with the overall goal of moving the field closer to developing effective preventive measures.

10 Jun 2019

Bacteriophage can have a profound impact on the dynamics of gut microbiome, study finds

The gut microbiome is a complex, interconnected ecosystem of species. And, like any ecosystem, some organisms are predators and some are prey.

7 Jun 2019

Three-drug combination could be effective therapy for people with advanced melanoma

A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma.

7 Jun 2019

Rettsyndrome.org funds research that will benefit boys and girls with MECP2-related disorders

Rettsyndrome.org announced their funding of two new research projects today. Jeannie T. Lee, MD, Ph.D. of Massachusetts General Hospital is awarded a two-year ANGEL Grant for $600,000 to focus on reactivating the silent X chromosome for Rett syndrome and Davut Pehlivan, MDof Baylor College of Medicine is awarded a two-year Mentored Clinical Fellowship for $250,000 to study MECP2 Duplication syndrome.

6 Jun 2019

Therapeutics News and Research

Harnessing the power of skin microbiome to develop new therapeutics

Novel approach of blocking inflammation before surgical procedure may prevent cancer recurrences

Researchers investigate why many cancer clinical trials fail to enroll enough patients

Harvard chemists achieve landmark in drug discovery with synthesis of potent anti-cancer agent

Research paves way for new treatment to protect people from cardiovascular disease

Scientists create 'mini-brain' for studying sporadic Creutzfeldt-Jakob disease

Novel insight could improve vaccines that protect pregnant women and newborns

Vitamin D metabolite may stop mechanism by which cancer cells become drug-resistant

Chemicals produced by gut microbiome could help identify children at risk of organ failure

New small drug-targeting molecules may improve cancer treatment

UAB researchers awarded $2.3 million grant to study macrophage circadian rhythms in heart failure

Norovirus structures could help develop therapeutics to fight food-borne illness

Scientists identify potential target for Parkinson's treatment

Study: Underweight boys and overweight girls have increased risk of depression

Plant-derived siRNAs could bring a 'green revolution' in RNAi tools and therapeutics

URMC biotech start-up receives funding to develop cell-based therapies for neurological disorders

Promising methods for early detection and treatment of rheumatoid arthritis

Bacteriophage can have a profound impact on the dynamics of gut microbiome, study finds

Three-drug combination could be effective therapy for people with advanced melanoma

Rettsyndrome.org funds research that will benefit boys and girls with MECP2-related disorders

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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