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Researchers study significance of water in a promising cancer biomarker

The UPV/EHU's Department of Physical Chemistry and the Biofísika Institute have conducted a multidisciplinary study of the Tn antigen that appears in 90% of cancers. Two variants that appear to be similar but which have very different shapes in water have been studied.

26 Oct 2018

New method for making mirrored forms of molecules

One of the biggest challenges facing synthetic chemists is how to make molecules of only a particular "handedness." Molecules can come in two shapes that mirror each other, just like our left and right hands.

26 Oct 2018

University of Alicante study: Antiparasitic Ivermectin six times more toxic than Moxidectin

Ivermectin is six times more toxic than Moxidectin for insects in charge of the recycling of organic matter. For the first time ever, there is scientific evidence based on physiological studies and this should be taken into account when using antiparasitic agents for livestock.

25 Oct 2018

Scientists identify new target for battling deadly form of leukemia

UT Southwestern scientists, working with colleagues at a sister institution in Houston, have identified a new target for battling a deadly form of leukemia.

24 Oct 2018

Researchers reach new milestone in understanding muscle formation

Researchers from the Randall Centre for Cell & Molecular Biophysics believe they have reached a new milestone in the understanding of muscle formation that could help define new cellular and molecular approaches in pathological conditions affecting muscle wellness.

24 Oct 2018

Researchers uncover new lead for mechanism of action of frontline Type 2 diabetes drug

Canadian and British researchers have discovered how the frontline Type 2 diabetes drug metformin may work to help cells better take up and use glucose.

24 Oct 2018

New type of molecule shows early promise against treatment-resistant prostate cancer

A new type of molecule blocks the action of genes that drive the growth of therapy-resistant prostate cancer, a new study finds.

23 Oct 2018

Scientists develop new class of compounds for treatment of progressive neurodegenerative disorder

St. Jude Children's Research Hospital investigators have developed a new class of compounds that extended the lives and eased symptoms of mice with a progressive neurodegenerative human disorder.

23 Oct 2018

Novartis: Lancet publishes pioneering study of Aimovig’s efficacy in episodic migraine patients

Novartis announced today that the full data from the LIBERTY study of Aimovig (erenumab) in episodic migraine patients who had tried and failed two to four prior preventive treatments have been published in the Lancet.

23 Oct 2018

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

AbbVie, a research-based global biopharmaceutical company, today announced positive results from U-ACHIEVE, an ongoing Phase 2b/3 dose-ranging study evaluating upadacitinib, an investigational JAK1-selective inhibitor, for induction and maintenance therapy in adult patients with moderately to severely active ulcerative colitis.

23 Oct 2018

Common antibodies associated with myocardial infarction

Levels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoimmune co-morbidity, a study from Karolinska Institutet in Sweden published in The Annals of Internal Medicine reports.

23 Oct 2018

SLU researcher seeks to find solutions for 'chemo brain' symptoms and side effects of opioids

With a pair of RO1 grants from the National Institutes of Health, pain researcher Daniela Salvemini, Ph.D., will embark on two new research projects, studying chemotherapy-induced cognitive impairment, or "chemo brain," symptoms and unwanted side effects of opioids.

23 Oct 2018

New topical gel can prevent pesticide-induced toxicity and lethality

Farmers are exposed to toxic pesticides, through skin contact and inhalation, during the spraying of pesticides. This is a severe health hazard. In the last year, from the Vidharbha region in Maharashtra alone, spraying is thought to have led to over 40 deaths, 25 cases of lost vision, and over 1000 hospitalizations.

22 Oct 2018

New protein sequencing technique could revolutionize biomedical research

Scientists have developed a new, low-throughput technique that allows individual proteins to be identified. It is called single molecule fluorosequencing.

22 Oct 2018

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Merck, known as MSD outside the United States and Canada, today announced the first presentation of preliminary data from a Phase 1 clinical trial evaluating MK-1454, an investigational STING (stimulator of interferon genes) agonist, as monotherapy and in combination with KEYTRUDA (pembrolizumab), Merck's anti-PD-1 therapy, in patients with advanced solid tumors or lymphomas.

22 Oct 2018

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Takeda Pharmaceutical Company Limited today announced results from the phase 3 VISIBLE 1 clinical trial evaluating the efficacy and safety of an investigational subcutaneous formulation of the gut-selective biologic vedolizumab for maintenance therapy in adult patients with moderately to severely active ulcerative colitis who achieved clinical response* at week 6 following two doses of open-label vedolizumab intravenous induction therapy.

22 Oct 2018

Deciphera presents Phase 1 clinical results of DCC-2618 in patients with gastrointestinal stromal tumors

Deciphera Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company focused on addressing key mechanisms of tumor drug resistance, announced the presentation today of updated preliminary results from its ongoing Phase 1 clinical study of DCC-2618, the company's broad-spectrum KIT and PDGFRα inhibitor, in patients with gastrointestinal stromal tumors as a proffered paper presentation at the European Society of Medical Oncology 2018 Congress in Munich, Germany.

22 Oct 2018

Gilead Sciences presents Phase 3 results of filgotinib in biologic-experienced rheumatoid arthritis at 2018 ACR/ARHP Annual Meeting

Gilead Sciences, Inc. and Galapagos NV today announced detailed results from the Phase 3 FINCH 2 clinical trial of filgotinib, an investigational, selective JAK1 inhibitor, in adults with moderately-to-severely active rheumatoid arthritis and prior inadequate response or intolerance to biologic agents.

22 Oct 2018

X4 Pharmaceuticals announces clinical data of X4P-001-IO and Opdivo in patients with clear cell renal cell carcinoma

X4 Pharmaceuticals, a clinical stage biotechnology company developing novel CXCR4 antagonists to improve immune cell trafficking to treat cancer and rare disease, today announced results from a pilot study of X4P-001-IO in combination with Opdivo (nivolumab) in patients with clear cell renal cell carcinoma who are non-responsive to the anti-PD-1 checkpoint inhibitor Opdivo alone.

22 Oct 2018

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions.

19 Oct 2018

Molecule News and Research

Researchers study significance of water in a promising cancer biomarker

New method for making mirrored forms of molecules

University of Alicante study: Antiparasitic Ivermectin six times more toxic than Moxidectin

Scientists identify new target for battling deadly form of leukemia

Researchers reach new milestone in understanding muscle formation

Researchers uncover new lead for mechanism of action of frontline Type 2 diabetes drug

New type of molecule shows early promise against treatment-resistant prostate cancer

Scientists develop new class of compounds for treatment of progressive neurodegenerative disorder

Novartis: Lancet publishes pioneering study of Aimovig’s efficacy in episodic migraine patients

AbbVie’s U-ACHIEVE Phase 2b/3 dose-ranging study improves outcomes in patients with ulcerative colitis

Common antibodies associated with myocardial infarction

SLU researcher seeks to find solutions for 'chemo brain' symptoms and side effects of opioids

New topical gel can prevent pesticide-induced toxicity and lethality

New protein sequencing technique could revolutionize biomedical research

Merck presents MK-1454 Phase 1 data for treatment of advanced solid tumors or lymphomas

Takeda presents vedolizumab phase 3 VISIBLE 1 trial results for treatment of moderately to severely active ulcerative colitis

Deciphera presents Phase 1 clinical results of DCC-2618 in patients with gastrointestinal stromal tumors

Gilead Sciences presents Phase 3 results of filgotinib in biologic-experienced rheumatoid arthritis at 2018 ACR/ARHP Annual Meeting

X4 Pharmaceuticals announces clinical data of X4P-001-IO and Opdivo in patients with clear cell renal cell carcinoma

Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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