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Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Researchers evaluated primary responses in SARS-CoV-2-naïve vaccinees, as well as secondary responses in the SARS-CoV-2-infected vaccines, and observed a clear set of differences in their clinical symptoms, antibody levels, and cellular and mucosal immune responses.

17 Dec 2021

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Researchers performed a meta-analysis of the results of four previous studies estimating fold-drop in neutralization titer against Omicron to present a combined estimate of the same.

17 Dec 2021

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

A new study measured antibody levels from blood samples of vaccinated individuals and individuals who recovered from COVID-19 illness.

17 Dec 2021

Study provides a more effective treatment approach to preventing graft-versus-host-disease

A new study led by UC Davis Health researchers showed that blocking IL-6 and TNF cytokines provides a more effective approach to preventing life-threatening graft-versus-host-disease (GVHD), an inflammatory condition that develops in patients after their allogeneic hematopoietic stem cell transplantation (allo-HSCT).

16 Dec 2021

PET scans can be used to see drug movement in the body to better treat bacterial infections

Treating bacterial infections associated with orthopaedic implants has often been a case of too little, too late.

16 Dec 2021

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A

Researchers determined the minimally effective dose (MED) of a clinical candidate gene therapy vector for treating hemophilia A.

16 Dec 2021

New study demonstrates SARS-CoV-2 Omicron antibody escape

A new study examined the neutralization of virus variants using three sets of antibodies: serum from individuals vaccinated or infected with earlier variants of the virus; concentrated human antibodies from plasma donors; and approved monoclonal antibodies.

16 Dec 2021

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

A new study reports the results of a study focused on immune evasion characteristics, specifically the ability to escape neutralization by antibodies to the earlier SARS-CoV-2 variants or to the spike antigen used in COVID-19 vaccines.

16 Dec 2021

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

A new study assesses the safety and efficacy of SARS-CoV-2 convalescent plasma containing high titers of anti-SARS-CoV-2 antibodies as PEP.

16 Dec 2021

Capability of BNT162b2 vaccine given in 2 or 3 doses to neutralize SARS-CoV-2 Omicron

The team observed that three doses of the BNT162b2 (Pfizer-BioNTech) mRNA vaccine are required to mount an effective antibody response against the Omicron variant.

16 Dec 2021

Scientists find better treatment options for patients with advanced colorectal cancer

City of Hope, a world-renowned cancer research and treatment organization, today announced study results of a Phase 2 clinical trial showing monotherapy with sotorasib resulted in anti-tumor activity and a favorable benefit-risk profile among heavily pretreated patients with advanced colorectal cancer. The research was published today in Lancet Oncology.

16 Dec 2021

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

A new study has used this assay to evaluate sera, obtained from 239 individuals vaccinated via any of the above-stated vaccines against SARS-CoV-2’s original strain, the Delta, and Omicron SARS-CoV-2 pseudoviruses.

16 Dec 2021

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Scientists identified a human monoclonal antibody (mAb), which successfully neutralized or bound all sarbecoviruses tested in vitro.

16 Dec 2021

Co-morbid insomnia and sleep apnea linked to greater mortality risk

People who suffer from both insomnia and obstructive sleep apnea are more likely to suffer from heart problems and are almost 50% more likely to die than those without either condition, say Flinders University researchers, who advise people being tested for one of the disorders be tested for the other.

16 Dec 2021

New combined therapy shows promising results in treating triple negative breast cancer

A drug used to treat cardiac failure has shown promising results in treating triple negative breast cancer, according to Houston Methodist researchers who released results this week on a new combined therapy with the potential to improve outcomes for these hard-to-treat breast cancer patients.

15 Dec 2021

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

A new study assessed nAb activities against five strains of SARS-CoV-2 in paired maternal and infant cord blood samples.

15 Dec 2021

Exploring the possibility of developing a plant-based oral vaccine against COVID-19

New research optimizes methods for the in-planta expression of the recombinant protein corresponding to the Receptor Binding Domain (RBD) subunit of the surface-exposed Spike glycoprotein of SARS-CoV-2.

15 Dec 2021

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

Researchers compared the binding of the new SARS-CoV-2 VOC Omicron’s RBD and ACE2 receptor with the original Wuhan SARS-CoV-2 strain and other VOCs such as Beta and Delta.

15 Dec 2021

West African countries must increase COVID-19 vaccination rates to achieve population-level immunity

West African nations need to drastically ramp up their COVID-19 vaccination programmes by factor of 10 if they are to reach at least 60% coverage by 2022 and achieve the population level immunity needed to bring the pandemic under control in Africa and elsewhere, indicates an analysis published in the open access journal BMJ Global Health.

15 Dec 2021

SARS-CoV-2 Omicron variant binding to its receptor and therapeutic entities

Researchers generated a set of computed structural models of the Omicron receptor-binding domain attached to its receptor angiotensin-converting enzyme.

15 Dec 2021

Efficacy News and Research

Primary responses to SARS-CoV-2 in COVID-19 naïve vaccinees

Prediction of waning COVID-19 vaccine efficacy against Omicron variant

Analysis of the alteration of neutralizing titers with Omicron pseudovirus

Study provides a more effective treatment approach to preventing graft-versus-host-disease

PET scans can be used to see drug movement in the body to better treat bacterial infections

Study determines minimally effective dose of clinical candidate gene therapy vector to treat hemophilia A

New study demonstrates SARS-CoV-2 Omicron antibody escape

Moderna booster vaccination overcomes SARS-CoV-2 Omicron variant antibody escape

Study suggests convalescent plasma appears safe but does not prevent SARS-CoV-2 infection

Capability of BNT162b2 vaccine given in 2 or 3 doses to neutralize SARS-CoV-2 Omicron

Scientists find better treatment options for patients with advanced colorectal cancer

Neutralization potency of COVID-19 vaccine boosters against SARS-CoV-2 variant pseudoviruses

Human monoclonal antibody protects against SARS-CoV-2 and SARS-CoV in vivo

Co-morbid insomnia and sleep apnea linked to greater mortality risk

New combined therapy shows promising results in treating triple negative breast cancer

Evaluation of SARS-CoV-2 neutralizing antibodies in mothers and infants

Exploring the possibility of developing a plant-based oral vaccine against COVID-19

Receptor binding of SARS-CoV-2 Omicron variant compared to other variants

West African countries must increase COVID-19 vaccination rates to achieve population-level immunity

SARS-CoV-2 Omicron variant binding to its receptor and therapeutic entities

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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