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A metabolomics approach to detect objective biomarkers of ASD

In a paper published online this week in Autism Research, scientists at NeuroPointDX, a division of Stemina Biomarker Discovery, Inc., in collaboration with researchers at the UC Davis MIND Institute and academic and clinical institutions across the country, report new findings from the Children's Autism Metabolome Project or CAMP.

18 Jun 2020

Scientists aim to understand the biology of SARS-CoV-2 virus to enable drug development

The University of Huddersfield has awarded funding to a research team that aims to provide a head start in developing drugs that will combat future pandemics.

18 Jun 2020

Thin adhesive film upgrades consumer smartwatch into a powerful health-monitoring system

UCLA engineers have designed a thin adhesive film that could upgrade a consumer smartwatch into a powerful health-monitoring system.

18 Jun 2020

Researchers solve structure of key enzyme critical for biofilm formation in fungal pathogen

Aspergillus fumigatus is a species of fungus that can cause serious illnesses in immunocompromised individuals such as those who are undergoing transplantation or cancer chemotherapy.

17 Jun 2020

New test could guide and improve treatment options for women with deadly ovarian cancer

University of British Columbia researchers have led an international team in developing a new test to better diagnose different types of ovarian cancer, a tool that could one day guide and improve treatment options for women diagnosed with the most common and deadliest form of the disease.

17 Jun 2020

Highly conserved RNA structures are essential for SARS-CoV-2 replication and pathogenesis

A recent study from the University of North Carolina at Chapel Hill revealed how selective pressure helps in preserving secondary RNA structures in coronavirus genomes, unveiling a pivotal role of these elements in viral replication and pathogenesis. The paper is currently available on the bioRxiv* preprint server.

17 Jun 2020

'Microbial dark matter' can affect cholesterol levels in humans

In the darkest parts of the world where light fails to block out the unfathomable bounty of the stars, look up. There are still fewer specks illuminating the universe than there are bacteria in the world, hidden from sight, a whole universe inside just one human gut.

17 Jun 2020

Even brief exposure to certain chemicals can prematurely age the liver epigenome

The epigenome is sometimes referred to as the "software" or "operating system" of the genome. It comprises small chemical modifications to DNA and the proteins that make up our chromosomes, and controls the activity of all the genes within the genome.

17 Jun 2020

Mapping RNA sequences of therapeutic value in the SARS-CoV-2 genome

Now, in new research published on the preprint server bioRxiv European scientists have performed RNA structure probing to obtain a single-base resolution secondary structure map of the full SARS-CoV-2 coronavirus genome.

17 Jun 2020

SARS-CoV-2 mutated spike proteins show variations in cell entry

A new study by Japanese scientists published on the preprint server bioRxiv* in June 2020 shows that the D614g mutation in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein can enhance the infectivity of the virus while leaving it vulnerable to neutralization by antibodies.

17 Jun 2020

Researchers receive federal funding to rapidly repurpose FDA-approved drugs for COVID-19

Researchers at the University of Maryland School of Medicine will be partnering on an agreement funded by the federal government's Defense Advanced Research Projects Agency (DARPA) to rapidly test hundreds of drugs, approved and marketed for other conditions, to see whether any can be repurposed to prevent or treat COVID-19.

16 Jun 2020

Exercise has profound protective effect in mouse models of Friedreich's ataxia

A top exercise researcher at the University of Virginia School of Medicine is urging clinical trials of exercise in patients with Friedreich's ataxia after finding that physical activity has a "profound" protective effect in mouse models of the debilitating genetic disease.

16 Jun 2020

Researchers analyze immune properties of ancient human DNA

Could remnants of DNA from a now-extinct human subspecies known as the Denisovans help boost the immune functions of modern humans?

16 Jun 2020

SARS-CoV-2 mutation reduces S1 shedding, increases infective potential

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the seventh coronavirus known to infect humans. SARS-CoV-2 emerged in the last month of 2019 in Wuhan, China, sparking off the ongoing COVID-19 pandemic. This virus enters the host cells through receptor binding and membrane fusion between the viral and host cell membrane.

16 Jun 2020

Tracing coronavirus habitats with genomics

Now, a new study by researchers at the University of Ottawa and published on the preprint server bioRxiv in June 2020 reports the differences in genomes of viruses that are exposed to antiviral proteins vs. those that are not. This host-derived pressure on the virus to adapt may help devise newer ways to build an effective vaccine.

15 Jun 2020

U.S. and European SARS CoV-2 mutation enhances transmission, increases infectivity

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that is causing the COVID-19 pandemic across the world has undergone a genetic mutation in the density of functional spikes on the virus, says a new study. This has led the virus to become highly infectious and easily transmissible between humans.

15 Jun 2020

Identifying early routes of SARS-CoV-2 introduction to Los Angeles

Researchers at Cedars-Sinai Medical Center, Los Angeles, have described for the first time, the likely sources of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduction to the Los Angeles community.

15 Jun 2020

Dante Labs, Cambridge Cancer Genomics and Nonacus collaborate to provide precision oncology at scale

Dante Labs, Cambridge Cancer Genomics, and Nonacus, today announced that they have signed a collaboration agreement.

15 Jun 2020

Chimeric reference standards for validating controls in SARS-CoV-2 tests

A preliminary study by researchers from the Garvan Institute of Medical Research and the University of New South Wales and published on the preprint server bioRxiv in June 2020 reports the use of chimeric design to produced reference standards for diagnostic tests. This could allow a highly flexible approach to the development of different genetic features in the same test, even for organisms that are not directly related.

15 Jun 2020

Effect of human genes on severity and infectivity of SARS-CoV-2

Now, a new paper published on the preprint server medRxiv* reports the results of an analysis of the association between the genetic variants in the patients and the clinical progression of the disease. The study included 332 patients hospitalized with COVID-19 in a single-center, with widely varying laboratory and clinical features. There were 25, 12, and 17 patients with asymptomatic, mild, and critical disease.

14 Jun 2020

Genome News and Research

A metabolomics approach to detect objective biomarkers of ASD

Scientists aim to understand the biology of SARS-CoV-2 virus to enable drug development

Thin adhesive film upgrades consumer smartwatch into a powerful health-monitoring system

Researchers solve structure of key enzyme critical for biofilm formation in fungal pathogen

New test could guide and improve treatment options for women with deadly ovarian cancer

Highly conserved RNA structures are essential for SARS-CoV-2 replication and pathogenesis

'Microbial dark matter' can affect cholesterol levels in humans

Even brief exposure to certain chemicals can prematurely age the liver epigenome

Mapping RNA sequences of therapeutic value in the SARS-CoV-2 genome

SARS-CoV-2 mutated spike proteins show variations in cell entry

Researchers receive federal funding to rapidly repurpose FDA-approved drugs for COVID-19

Exercise has profound protective effect in mouse models of Friedreich's ataxia

Researchers analyze immune properties of ancient human DNA

SARS-CoV-2 mutation reduces S1 shedding, increases infective potential

Tracing coronavirus habitats with genomics

U.S. and European SARS CoV-2 mutation enhances transmission, increases infectivity

Identifying early routes of SARS-CoV-2 introduction to Los Angeles

Dante Labs, Cambridge Cancer Genomics and Nonacus collaborate to provide precision oncology at scale

Chimeric reference standards for validating controls in SARS-CoV-2 tests

Effect of human genes on severity and infectivity of SARS-CoV-2

Genetics & Genomics - Second Edition eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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