Molecule News and Research

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New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Today, Insilico Medicine, Inc., a Rockville-based next-generation artificial intelligence company specializing in the application of deep learning for target identification, drug discovery and aging research announces the publication of a new research paper "Entangled Conditional Adversarial Autoencoder for de-novo Drug Discovery" in Molecular Pharmaceutics, the leading American Chemical Society journal covering research on the molecular mechanistic understanding of drug delivery and drug delivery systems

12 Sep 2018

Particular immune cell seems to play key role in determining male or female characteristics

Researchers at the University of Maryland School of Medicine have made a surprising discovery: during fetal development, a particular immune cell seems to play a key role in determining the male or female characteristics of the brain.

12 Sep 2018

Discovery of unusual biosynthetic pathways could aid in the search for new natural products

Bacteria are master engineers of small, biologically useful molecules. A new study in Nature Communications has revealed one of the tricks of this microbial trade: synthesizing and then later inserting a nitrogen-nitrogen bond, like a prefabricated part, into a larger molecule.

12 Sep 2018

Inhaled form of high blood pressure drug has potential to treat anxiety, pain

An inhaled form of a high blood pressure medication has potential to treat certain types of anxiety as well as pain, according to a new study by the Centre for Addiction and Mental Health.

11 Sep 2018

Molecule produced during fasting appears to have anti-aging effects on vascular system

A molecule produced during fasting or calorie restriction has anti-aging effects on the vascular system, which could reduce the occurrence and severity of human diseases related to blood vessels, such as cardiovascular disease, according to a study led by Georgia State University.

11 Sep 2018

Researchers reveal effect of high amounts of cholesterol on specific ion channel in heart

Using a computer model, researchers from North Carolina State University and the University of Illinois at Chicago have revealed the effect of increased amounts of cholesterol on a specific ion channel involved in regulating potassium levels in the heart.

11 Sep 2018

Researchers unravel how Zika virus manipulates the human immune system

Macrophages are immune cells that are supposed to protect the body from infection by viruses and bacteria. Yet Zika virus preferentially infects these cells. Researchers at University of California San Diego School of Medicine have now unraveled how the virus shuts down the genes that make macrophages function as immune cells.

11 Sep 2018

New screening strategy identifies novel inhibitors that may help develop cure for Parkinson's

Parkinson's disease is the most common movement disorder in the world. PD patients suffer from shaking, rigidity, slowness of movement and have difficulties walking.

10 Sep 2018

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

UC San Francisco researchers have discovered how a mutation in a gene regulator called the TERT promoter -- the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma -- confers "immortality" on tumor cells, enabling the unchecked cell division that powers their aggressive growth.

10 Sep 2018

Metabolic dysfunction drives chronic illness

Much of modern Western medicine is based upon the treatment of acute, immediate harm, from physical injury to infections, from broken bones and the common cold to heart and asthma attacks.

7 Sep 2018

Researchers develop new generation of pain medications

Researchers from Charité - Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of pain medications.

7 Sep 2018

Researchers test experimental cancer vaccine on mice with aggressive melanoma

An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumors, scientists reported recently in the Proceedings of the National Academy of Sciences.

7 Sep 2018

Research team identifies new therapeutic target for castration-resistant prostate cancer

A collaborative research team has linked the development of castration-resistant prostate cancer and resistance to treatment to a lack of androgen receptor expression in prostate cancer cells, identifying a new therapeutic target for one of the deadliest forms of cancer among men.

7 Sep 2018

Natural plant compound exploits newly identified Achilles' heel in uveal melanoma

A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis.

6 Sep 2018

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

BeiGene, Ltd., a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly-targeted and immuno-oncology drugs for the treatment of cancer, and SpringWorks Therapeutics, a clinical-stage rare disease and oncology company focused on sourcing and developing innovative treatments for underserved patient populations, announced today that the companies have entered into a global clinical collaboration agreement to evaluate the safety, tolerability and preliminary efficacy of combining BeiGene's investigational RAF dimer inhibitor, lifirafenib and SpringWorks Therapeutics' investigational MEK inhibitor, PD-0325901, in patients with advanced solid tumors.

6 Sep 2018

Researchers discover natural plant compound that shuts down uveal melanoma cell growth

A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma.

6 Sep 2018

New system accelerates discovery of chemical compounds that inhibit enzyme implicated in cancers

Researchers at the National Center for Advancing Translational Sciences, part of the National Institutes of Health, have developed a system to accelerate the discovery of chemical compounds that inhibit an enzyme implicated in a number of cancers.

6 Sep 2018

New LSU research aims to prevent kidney failure caused by type 2 diabetes

A National Institutes of Health grant will help LSU Pennington Biomedical Research Center take the next step to better understanding how to prevent the kidney damage and failure caused by type 2 diabetes.

6 Sep 2018

UNH researchers aim to better understand dehydration and help humans survive it

A grant from the National Institutes of Health will help a University of New Hampshire researcher better understand dehydration and ultimately help humans better survive it by studying a tiny desert rodent that's adapted to survive both acute and chronic dehydration.

6 Sep 2018

Researchers discover how a protein complex safeguards against certain brain tumors

Researchers have discovered how a molecule can help prevent certain types of brain tumors by recognizing and 'disarming' harmful proteins that cause them.

5 Sep 2018

Molecule News and Research

New research on molecular mechanistic understanding of drug delivery and drug delivery systems

Particular immune cell seems to play key role in determining male or female characteristics

Discovery of unusual biosynthetic pathways could aid in the search for new natural products

Inhaled form of high blood pressure drug has potential to treat anxiety, pain

Molecule produced during fasting appears to have anti-aging effects on vascular system

Researchers reveal effect of high amounts of cholesterol on specific ion channel in heart

Researchers unravel how Zika virus manipulates the human immune system

New screening strategy identifies novel inhibitors that may help develop cure for Parkinson's

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

Metabolic dysfunction drives chronic illness

Researchers develop new generation of pain medications

Researchers test experimental cancer vaccine on mice with aggressive melanoma

Research team identifies new therapeutic target for castration-resistant prostate cancer

Natural plant compound exploits newly identified Achilles' heel in uveal melanoma

BeiGene collaborates with SpringWorks to evaluate new combinational therapy for solid tumors

Researchers discover natural plant compound that shuts down uveal melanoma cell growth

New system accelerates discovery of chemical compounds that inhibit enzyme implicated in cancers

New LSU research aims to prevent kidney failure caused by type 2 diabetes

UNH researchers aim to better understand dehydration and help humans survive it

Researchers discover how a protein complex safeguards against certain brain tumors

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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