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Monocytes promote viral control during SARS-COV-2 infection

In a paper recently uploaded to the preprint server bioRxiv by Vanderheiden et al. (May 4th, 2021) the contribution of monocytes in promoting protective immunity from SARS-CoV-2 is investigated in a murine model, suggesting that CCR2 plays the role of an inflammation modulator in early infection.

6 May 2021

PET imaging can enable accurate diagnosis of recurring brain metastases

For patients with brain metastases, amino acid positron emission tomography (PET) can provide valuable information about the effectiveness of state-of-the-art treatments.

5 May 2021

Key mechanism behind mutant p53 aggregation process is linked to cancer pathology

Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors.

5 May 2021

Study identifies novel combination therapy to help patients with advanced lung cancer

A new study by researchers at the UCLA Jonsson Comprehensive Cancer Center has identified a novel combination therapy to potentially help overcome resistance to immunotherapy in people diagnosed with advanced lung cancer.

5 May 2021

Biomedical engineer receives NIH Trailblazer grant to advance research on paralysis, brain damage

Imagine harnessing the proliferating power of cancer cells to treat spinal cord injuries and restore function following brain damage. It's an idea that University of Massachusetts Amherst biomedical engineer Chase Cornelison has been exploring in recent years.

5 May 2021

Penn State researchers develop a way to study microenvironment of breast cancer in 3D

Cancerous tumors thrive on blood, extending their roots deep into the fabric of the tissue of their host. They alter the genetics of surrounding cells and evolve to avoid the protective attacks of immune cells.

4 May 2021

Researchers develop new technology to reduce high error rates in gene sequencing

Next-generation gene sequencing (NGS) technologies --in which millions of DNA molecules are simultaneously but individually analyzed-- theoretically provides researchers and clinicians the ability to noninvasively identify mutations in the blood stream.

4 May 2021

SARS-CoV-2 study in human gut organoids

Most of the major life-threatening symptoms of COVID-19 disease are associated with the host's generation of an exacerbated pro-inflammatory immune response. Many studies have correlated the intensity of the immune response with the severity of disease.

3 May 2021

Review outlines ways to effectively deliver radiotherapy to optimize benefit and minimize risk

A comprehensive review by University of North Carolina researchers and colleagues highlights the optimal ways that focused, high-dose radiation can be delivered to various types of tumors while sparing normal tissue and mitigating long-term side effects.

3 May 2021

Chemotherapy drugs delivered via nanoparticles could improve bowel cancer survival rates

Bowel cancer survival rates could be improved if chemotherapy drugs were delivered via tiny nanoparticles to the diseased organs rather than oral treatment.

3 May 2021

Novel method provides faster and more precise diagnostics in histopathology

Histology is the study of biological tissues at a microscopic level. Also called microscopic anatomy, histology is widely used to provide diagnosis of cancer and other diseases.

30 Apr 2021

Arresting tumor growth for a variety of cancers through T cell engineering

Through T cell engineering, researchers at Virginia Commonwealth University Massey Cancer Center show that it's possible to arrest tumor growth for a variety of cancers and squash the spread of cancer to other tissues.

30 Apr 2021

Scientists develop an ultrasonic imaging system to visualize cell abnormalities in 3D

Scientists at the University of Nottingham have developed an ultrasonic imaging system, which can be deployed on the tip of a hair-thin optical fiber, and will be insertable into the human body to visualize cell abnormalities in 3D.

30 Apr 2021

Novel integrative genetic screening platform offers insights into role of DNA accessibility in cancer

In a new resource for the scientific community, published today in Nature Biotechnology, researchers in the lab of Neville Sanjana, PhD, at the New York Genome Center (NYGC) and New York University (NYU) developed CRISPR-sciATAC, a novel integrative genetic screening platform that jointly captures CRISPR gene perturbations and single-cell chromatin accessibility genome-wide.

30 Apr 2021

Study evaluates first tumor-uninformed ctDNA assay to detect residual cancer cells after treatment

After patients with cancer undergo surgery to remove a tumor and sometimes additional chemotherapy, tools are used to identify patients at highest risk of recurrence.

30 Apr 2021

New book provides details on the roles of inflammation in head and neck malignancy

'Head and Neck Cancer: Hallmarks of The Inflammation Ecosystem' aims to highlight the significant roles of inflammation in head and neck malignancy.

29 Apr 2021

Host protein mimicry of SARS-CoV-2 receptor binding motif

In a new study, structural bioinformatics approaches are employed to investigate the potential mimicry of the receptor-binding motif (RBM) of these three coronaviruses, finding that several proteins from both human and non-human sources were similar to each, with implications regarding the mechanism of infection and tropism of SARS-CoV-2.

29 Apr 2021

Pancreatic cancer cells de-differentiate to spawn highly aggressive tumors, study shows

A Ludwig Cancer Research study has identified a previously unrecognized mechanism by which cancer cells of a relatively benign subtype of pancreatic tumors methodically revert-or "de-differentiate"-to a progenitor, or immature, state of cellular development to spawn highly aggressive tumors that are capable of metastasis to the liver and lymph nodes.

29 Apr 2021

New exosome-based therapeutic strategy to potentially treat late-stage colorectal cancer

In a recent discovery by University of Minnesota Medical School, researchers uncovered a new way to potentially target and treat late-stage colorectal cancer - a disease that kills more than 50,000 people each year in the United States.

29 Apr 2021

Male bladder cancer vulnerability could be exploited to design new therapeutic strategies

A protein variant common in malignant bladder tumor cells may serve as a new avenue for treating bladder cancer.

29 Apr 2021

Tumor News and Research

Monocytes promote viral control during SARS-COV-2 infection

PET imaging can enable accurate diagnosis of recurring brain metastases

Key mechanism behind mutant p53 aggregation process is linked to cancer pathology

Study identifies novel combination therapy to help patients with advanced lung cancer

Biomedical engineer receives NIH Trailblazer grant to advance research on paralysis, brain damage

Penn State researchers develop a way to study microenvironment of breast cancer in 3D

Researchers develop new technology to reduce high error rates in gene sequencing

SARS-CoV-2 study in human gut organoids

Review outlines ways to effectively deliver radiotherapy to optimize benefit and minimize risk

Chemotherapy drugs delivered via nanoparticles could improve bowel cancer survival rates

Novel method provides faster and more precise diagnostics in histopathology

Arresting tumor growth for a variety of cancers through T cell engineering

Scientists develop an ultrasonic imaging system to visualize cell abnormalities in 3D

Novel integrative genetic screening platform offers insights into role of DNA accessibility in cancer

Study evaluates first tumor-uninformed ctDNA assay to detect residual cancer cells after treatment

New book provides details on the roles of inflammation in head and neck malignancy

Host protein mimicry of SARS-CoV-2 receptor binding motif

Pancreatic cancer cells de-differentiate to spawn highly aggressive tumors, study shows

New exosome-based therapeutic strategy to potentially treat late-stage colorectal cancer

Male bladder cancer vulnerability could be exploited to design new therapeutic strategies

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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