Tumor Necrosis Factor News and Research

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The impact of multiple sclerosis therapy on COVID-19 vaccine efficacy

In a paper, the vaccine-induced cellular and immune response of MS patients receiving a range of therapies are assessed.

23 Sep 2021

Changes in fibrin clot structure contributes to thrombosis risk in severe COVID-19

Researchers from Europe recently demonstrated altered levels of factor XII (FXII) and its activation products in 2 independent cohorts of critically ill patients with COVID-19 compared to patients suffering from severe acute respiratory distress syndrome caused by the influenza virus (acute respiratory distress syndrome (ARDS)-influenza).

21 Sep 2021

Flu shots and COVID-19 immunity

A new paper finds that the influenza vaccine may influence both the response to and incidence of infection by the SARS-CoV-2.

14 Sep 2021

Researchers explore whether cocoa supplementation can reduce aging

Whether consuming cocoa, known to be packed with powerful antioxidants that protect our cells from damage, helps us age better, is a question scientists want to definitively answer.

14 Sep 2021

Immune-mediated inflammatory disease may increase risk of severe COVID-19 outcomes

Researchers in the UK have conducted a large population-based study showing that people with immune-mediated inflammatory diseases (IMIDs) appear to be at an increased risk of serious outcomes from coronavirus disease 2019 (COVID-19).

14 Sep 2021

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

A new study discusses the role of obesity in COVID-19 and its role in antibody-mediated immune responses to the COVID-19 vaccine.

7 Sep 2021

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

An intriguing new study reports a year-long study in patients with cMCADs from all over France.

7 Sep 2021

Decreased COVID-19 vaccine efficacy amongst IBS patients receiving anti-TNFα drugs

In a paper recently uploaded to the preprint server medRxiv* by Edelman-Klapper et al., the efficacy of the mRNA vaccine is examined amongst IBD patients and compared with healthy volunteers, finding reduced efficacy amongst those receiving anti-TNFα medication.

6 Sep 2021

New study analyzes altered gene expression in severe COVID-19

In a paper recently uploaded to the bioRxiv* preprint server, the genetic link between COVID-19 severity and gene expression is investigated, hoping to allow early identification of otherwise healthy individuals that will likely require hospitalization if infected.

30 Aug 2021

Next-gen COVID vaccine to make persistent neutralizing antibodies

Presently, there is a need to develop improved versions of COVID-19 vaccines that are effective against the SARS-CoV-2 variants of concern (VOC) and can confer long-term protection. Considering the need of the hour, scientists from the University of Sydney in Australia have generated a new COVID-19 vaccine CoVac-II and evaluated its effect against COVID-19 strains. The findings from this study are published on the bioRxiv* preprint server while awaiting peer review.

30 Aug 2021

Glycyrrhizic acid as a drug candidate for COVID-19

A new study presents the benefits of licorice, an age-old herbal remedy, to treat COVID-19 at all stages.

24 Aug 2021

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

The absence of a protein that activates the body's antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition that is treatable with an FDA-approved class of drugs known as TNF (tumor necrosis factor) inhibitors, a global research team led by Mount Sinai has found.

19 Aug 2021

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

A new study has revealed the mechanism by which the SARS-CoV-2 N protein activates NLRP3 inflammasomes to induce hyperinflammation.

5 Aug 2021

Flagging potential molecular predictors of response to biological therapies in ulcerative colitis

Several individuals suffering from bowel diseases like ulcerative colitis fail to respond to conventionally used biologic therapies.

3 Aug 2021

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

A study analyzes the immune responses of medical personnel, as well as immunocompromised DP and immunosuppressed KTR patients.

27 Jul 2021

Study sheds light on immune processes involved in long COVID

Researchers in the United States have provided important insights into the immune processes that may be associated with post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection – also referred to as long COVID (coronavirus disease 2019).

12 Jul 2021

Enzyme inhibitor boosts immune system to fight MRSA and other dangerous skin infections

In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.

8 Jul 2021

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

New research evaluating the drugs commonly used by rheumatoid arthritis patients suggests two combinations could reduce the risk of heart attack and strokes.

6 Jul 2021

Elevated levels of circulating proteins linked with protection against diabetic kidney disease

Elevated levels of three specific circulating proteins are associated with protection against kidney failure in diabetes, according to research from the Joslin Diabetes Center that will be published 30th June in Science Translational Medicine.

30 Jun 2021

Differences in monocyte subsets between severe COVID-19 and long COVID

Researchers in the United States and Costa Rica have identified differences in the proportions of monocyte subsets that occur in severe cases of coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and post-acute sequelae of COVID-19 (PASC), often referred to as “Long COVID”.

28 Jun 2021

Tumor Necrosis Factor News and Research

The impact of multiple sclerosis therapy on COVID-19 vaccine efficacy

Changes in fibrin clot structure contributes to thrombosis risk in severe COVID-19

Flu shots and COVID-19 immunity

Researchers explore whether cocoa supplementation can reduce aging

Immune-mediated inflammatory disease may increase risk of severe COVID-19 outcomes

COVID-19 vaccine antibodies inversely related to BMI in obese men, but not women

Activated mast cell disorders potentially linked to SARS-CoV-2 immunity

Decreased COVID-19 vaccine efficacy amongst IBS patients receiving anti-TNFα drugs

New study analyzes altered gene expression in severe COVID-19

Next-gen COVID vaccine to make persistent neutralizing antibodies

Glycyrrhizic acid as a drug candidate for COVID-19

Study identifies the cause and treatment for rare rheumatoid-like autoinflammatory condition

Activation of NLRP3 inflammasome by the N protein of SARS-CoV-2 to induce hyperinflammation

Flagging potential molecular predictors of response to biological therapies in ulcerative colitis

Immunity to SARS-CoV-2 in renal transplant and dialysis patients using Pfizer/BioNTech and Moderna vaccines

Study sheds light on immune processes involved in long COVID

Enzyme inhibitor boosts immune system to fight MRSA and other dangerous skin infections

Anti-rheumatic drug combinations could reduce the risk of heart attack and strokes

Elevated levels of circulating proteins linked with protection against diabetic kidney disease

Differences in monocyte subsets between severe COVID-19 and long COVID

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