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New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combining the JAK inhibitor ruxolitinib with the BCL-xL inhibitor navitoclax was twice as effective in reducing enlarged spleens – a major indicator of clinical improvement – compared with standard-of-care ruxolitinib monotherapy for adult patients with intermediate or high-risk myelofibrosis, a rare bone marrow cancer, according to results of the Phase III TRANSFORM-1 trial reported by researchers from The University of Texas MD Anderson Cancer Center.

11 Dec 2023

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who were not good candidates for the standard treatment of intensive chemotherapy had a median overall survival (OS) of 6.5 years on an alternate regimen of dasatinib and blinatumomab.

11 Dec 2023

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

Early results from a Phase I clinical trial of AT101, a new CAR T cell therapy that uses a distinct binding mechanism to target CD19, show a 100 percent complete response (CR) rate at the higher dose levels studied in the trial, according to researchers from the University of Pennsylvania Perelman School of Medicine and Penn Medicine's Abramson Cancer Center.

11 Dec 2023

New organoid model could revolutionize neuroendocrine tumor research

The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab.

11 Dec 2023

Natural compound activates macrophages to fight resistant tuberculosis bacteria

Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic.

11 Dec 2023

From surviving to thriving: a framework for long-term success in people with HIV

NewsMedical spoke to Lisa Sterman, Global Executive Director, Global HIV Medical Affairs, Gilead Sciences, about the recently published LTS framework, recently highlighted at the opening ceremony of the 19th European AIDS Conference, which takes a person-centric approach to the HIV treatment journey.

From Gilead Sciences, Inc. 11 Dec 2023

Researchers develop novel exosome-based drug delivery system to treat Alzheimer's disease

A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer’s disease (AD).

11 Dec 2023

Phase 2 trial data shows safety, tolerability and efficacy of imlifidase in GBS patients

Hansa Biopharma today announced positive high-level data from the 15-HMedIdeS-09 phase 2 trial that demonstrated imlifidase was safe and well tolerated when administered prior to standard of care, including rapid improvement in disease-related efficacy measures.

11 Dec 2023

Small molecule applications of process Raman spectroscopy

In this interview, Kevin Broadbelt of Thermo Fisher Scientific discusses the small molecule applications of process Raman spectroscopy.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 11 Dec 2023

Varied early symptoms of bacterial meningitis in adults and children highlight diagnostic challenges

This study in Scientific Reports reveals that symptoms of community-acquired bacterial meningitis (CABM) vary between children and adults, emphasizing the need for tailored approaches in early diagnosis and treatment to improve outcomes.

10 Dec 2023

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study demonstrates that inhibiting stromal class I histone deacetylases (HDACs) can effectively slow down pancreatic cancer progression, shedding light on a new therapeutic approach targeting the tumor microenvironment.

10 Dec 2023

Study explores the intricate gut-brain-liver connection and its impact on health

Study reviews the gut-brain-liver axis, revealing the complex interplay between these organs in health and disease and the implications for therapeutic interventions, focusing on how gut microbiota affects liver and brain health.

10 Dec 2023

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

The University of Texas MD Anderson Cancer Center and Rigel Pharmaceuticals, Inc. today announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia (AML) and other hematologic cancers.

8 Dec 2023

Study identifies targetable fusion RNAs in breast cancer

Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023.

8 Dec 2023

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

USF Health Heart Institute doctors are upbeat about cardiac regeneration. But when those batteries – heart muscle cells called cardiomyocytes − short circuit and die, the damage can be devastating.

8 Dec 2023

Many patients may not benefit from gene-editing treatments for sickle cell disease

Federal approval of a breakthrough gene-editing technology that treats the pain and debilitating effects of sickle cell disease is cause for celebration among a community with few options for relief.

8 Dec 2023

VUB researchers develop a nanobody-based technology to prevent liver inflammation

Mathieu Vinken, a professor in the In Vitro Toxicology and Dermato-cosmetology (IVTD) lab at the Vrije Universiteit Brussel, and doctoral student Raf Van Campenhout have developed a technique based on nanobody technology to prevent liver inflammation.

8 Dec 2023

Closing the gender gap in HIV treatment could slash infection rates in Uganda

A study looking at 15 years of HIV transmission and suppression in Uganda reveals how closing gender gaps in treatment could slash infection rates.

8 Dec 2023

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Study examines the efficacy of anastrozole in preventing breast cancer in postmenopausal women at high risk, focusing on the role of baseline estradiol levels and their impact on treatment outcomes.

7 Dec 2023

Liver trigger holds the key to boosting gene therapy success

Indiana University School of Medicine researchers have uncovered vital insights regarding a liver trigger that blocks an undesired immune response from gene therapy, surprisingly resulting in the activation of specific immune cells, despite the liver's typical role in suppressing immune responses.

7 Dec 2023

Therapy News and Research

New drug combination doubles effectiveness in shrinking enlarged spleens in myelofibrosis patients

Combination of dasatinib and blinatumomab offers effective treatment for older Ph+ ALL patients

Phase I clinical trial of new CAR T cell therapy AT101 shows promising early responses

New organoid model could revolutionize neuroendocrine tumor research

Natural compound activates macrophages to fight resistant tuberculosis bacteria

From surviving to thriving: a framework for long-term success in people with HIV

Researchers develop novel exosome-based drug delivery system to treat Alzheimer's disease

Phase 2 trial data shows safety, tolerability and efficacy of imlifidase in GBS patients

Small molecule applications of process Raman spectroscopy

Varied early symptoms of bacterial meningitis in adults and children highlight diagnostic challenges

Breakthrough in pancreatic cancer treatment: Inhibiting specific enzymes slows tumor progression

Study explores the intricate gut-brain-liver connection and its impact on health

MD Anderson and Rigel partner to expand olutasidenib evaluation in AML and other cancers

Study identifies targetable fusion RNAs in breast cancer

Study offers new hope for heart repair and regeneration with reduced mitochondrial activity

Many patients may not benefit from gene-editing treatments for sickle cell disease

VUB researchers develop a nanobody-based technology to prevent liver inflammation

Closing the gender gap in HIV treatment could slash infection rates in Uganda

Anastrozole efficacy in breast cancer prevention for high-risk women linked to estrogen levels

Liver trigger holds the key to boosting gene therapy success

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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