Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Study shows that periodontal treatment can reduce symptoms of prostatitis

Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology and Pathology at University Hospitals Case Medical Center.

6 May 2015

Ground-breaking study characterizes early-stage Alzheimer's abnormalities in the intact brain

Alzheimer's disease (AD) is a neurodegenerative condition that strikes at the heart of what makes us human: the ability to think, to feel, to remember and to communicate with those around us. The tragedy is compounded by the fact that there is currently no cure, no treatment, and no diagnostic method capable of identifying Alzheimer's at its early stages.

6 May 2015

Novel combination therapy shows promise in mouse models of advanced prostate cancer

Chemotherapy can be very effective against small prostate tumors. Larger prostate tumors, however, accumulate cells that suppress the body's immune response, allowing the cancer to grow despite treatment.

30 Apr 2015

Long-term survivors of esophageal cancer still face continued risks, study finds

Patients with esophageal cancer who survive 5 years after undergoing surgery might breathe a sigh of relief and become complacent about continued monitoring. In fact, there is little published information on the outcome of patients with locally advanced esophageal cancer (LAEC) who survive beyond the 5-year mark.

30 Apr 2015

Lung volume reduction surgery could improve lung function in emphysema patients

Emphysema is a chronic, progressive, obstructive lung disease in which the small sacs of the lung (alveoli) are destroyed, leading to air pockets and severe breathing difficulties. In 2011, 4.7 million Americans reported being diagnosed with emphysema, and in 2013 more than 8200 patients died from emphysema.

30 Apr 2015

McMaster researchers explore how surgeon's experience influences choice of surgery for patients

Researchers at McMaster University (Hamilton, ON) explored whether a surgeon's expertise influences procedural choice. The results of a new study of more than 8000 non-small cell lung cancer (NSCLC) patients undergoing surgical resection by 124 physicians showed that surgeons who perform more surgeries are less likely to perform high-risk pneumonectomies. Christian J. Finley, MD, MPH, will be presenting the results of this research at the 95th AATS Annual Meeting in Seattle, WA on April 28, 2015.

29 Apr 2015

Innovative, active post-discharge intervention program benefits thoracic surgery patients

Post-surgical hospital readmission after discharge and repeat emergency room (ER) visits are not unusual for patients who have undergone major thoracic surgery. Recognizing this problem, clinicians at McMaster University have implemented an innovative, active post-discharge intervention for thoracic surgery patients that is based on the principle of a "one team-one approach" that is initiated while the patient is still hospitalized.

29 Apr 2015

Lung cancer surgery patients at higher risk of developing venous thromboembolism

New evidence suggests that lung cancer surgery patients are at higher risk of developing venous thromboembolism, including deep vein thrombosis (DVT) and pulmonary embolism (PE), than previously thought, with elevated risks of complications or death. When thromboemboli occur, they may be asymptomatic or attributed to post-surgical pain or complications, and may reflect both the lung cancer itself as well as compromised lung function after surgery.

29 Apr 2015

Men undergoing circumcision may be at increased risk of infecting female partners with HIV

In the midst of an international campaign to slow the spread of HIV in sub-Saharan Africa, the World Health Organization recommends male circumcision (the surgical removal of foreskin from the penis) which reduces HIV acquisition by 50-60%.

29 Apr 2015

Young age and small body weight predispose pediatric CHD patients toward re-intervention

A retrospective review of 633 adults and children who underwent bioprosthetic pulmonary valve replacement (PVR) for congenital heart disease between 1996 and 2014 indicated that the risk of re-intervention was five times greater for children than adults, with the likelihood of re-intervention decreasing by 10% for each increasing year of age at surgery.

29 Apr 2015

Special issue of Gastroenterology highlights how food impacts health and disease

Patients are always interested in understanding what they should eat and how it will impact their health. Physicians are just as interested in advancing their understanding of the major health effects of foods and food-related diseases.

28 Apr 2015

NeoGenomics' revenue increases 27% to $23.0 million in first quarter 2015

NeoGenomics, Inc., a leading provider of cancer-focused genetic testing services today reported its results for the first quarter of 2015.

28 Apr 2015

PAML signs collaborative agreement with Axela

PAML announced today that the laboratory has entered into a collaborative agreement with Axela, Inc. to develop multiplex assays focused on immune status for vaccine preventable diseases. PAML is one of the nation's leading medical reference laboratories, and Axela focuses on multiplexed nucleic acid and protein analysis for clinical diagnostics.

28 Apr 2015

Researchers identify molecular switch for protein that causes HER2-positive breast cancer

Herceptin has been touted as a wonder drug for women with HER2-positive breast cancer, an aggressive form of the disease that is fueled by excess production of the HER2 protein. However, not all of these patients respond to the drug, and many who do respond eventually acquire resistance.

28 Apr 2015

Elekta introduces new Leksell Gamma Knife Icon to treat patients with brain disease

With the introduction of Elekta's new Leksell Gamma Knife Icon, the benefits of precision cranial radiosurgery are now available for more patients with a wider variety of tumor types and sizes.

From Elekta 25 Apr 2015

Study: Long-term exposure to air pollution can damage brain structures, impair cognitive function

Air pollution, even at moderate levels, has long been recognized as a factor in raising the risk of stroke. A new study led by scientists from Beth Israel Deaconess Medical Center and Boston University School of Medicine suggests that long-term exposure can cause damage to brain structures and impair cognitive function in middle-aged and older adults.

24 Apr 2015

AMP report provides overview of current research on minimally invasive 'liquid biopsy' approaches

The Association for Molecular Pathology, the premier global, non-profit organization serving molecular diagnostic professionals, today published a special article in The Journal of Molecular Diagnostics titled, "Do Circulating Tumor Cells, Exosomes, and Circulating Tumor Nucleic Acids Have Clinical Utility?" The report provides a thorough overview of research to-date on the minimally invasive "liquid biopsy" approaches to cancer diagnostics.

23 Apr 2015

First evidence-based guideline released to ensure patient safety

Today, the College of American Pathologists and the National Society for Histotechnology released the first evidence-based guideline to ensure patient safety through the uniform labeling of paraffin blocks and slides.

23 Apr 2015

ADCs based on alpha-amanatin may help treat colorectal cancer

For some time, cancer scientists have considered the toxin, alpha-amanatin derived from "death cap" mushrooms, as a possible cancer treatment. However, due to its penchant for causing liver toxicity, its potential as an effective therapy has been limited.

23 Apr 2015

New UM SOM study uncovers never-before-seen illness transmitted by ticks

Tick-borne diseases are a major public health problem around the world. Ticks carry and transmit a variety of microbes that cause disease. These illnesses, which include Lyme disease, Rocky Mountain spotted fever, and Tularemia, can cause a variety of symptoms, often serious and sometimes deadly.

23 Apr 2015

Pathology News and Research

Further Reading

Study shows that periodontal treatment can reduce symptoms of prostatitis

Ground-breaking study characterizes early-stage Alzheimer's abnormalities in the intact brain

Novel combination therapy shows promise in mouse models of advanced prostate cancer

Long-term survivors of esophageal cancer still face continued risks, study finds

Lung volume reduction surgery could improve lung function in emphysema patients

McMaster researchers explore how surgeon's experience influences choice of surgery for patients

Innovative, active post-discharge intervention program benefits thoracic surgery patients

Lung cancer surgery patients at higher risk of developing venous thromboembolism

Men undergoing circumcision may be at increased risk of infecting female partners with HIV

Young age and small body weight predispose pediatric CHD patients toward re-intervention

Special issue of Gastroenterology highlights how food impacts health and disease

NeoGenomics' revenue increases 27% to $23.0 million in first quarter 2015

PAML signs collaborative agreement with Axela

Researchers identify molecular switch for protein that causes HER2-positive breast cancer

Elekta introduces new Leksell Gamma Knife Icon to treat patients with brain disease

Study: Long-term exposure to air pollution can damage brain structures, impair cognitive function

AMP report provides overview of current research on minimally invasive 'liquid biopsy' approaches

First evidence-based guideline released to ensure patient safety

ADCs based on alpha-amanatin may help treat colorectal cancer

New UM SOM study uncovers never-before-seen illness transmitted by ticks

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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