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Centauri Therapeutics receives an additional $5.1 M from CARB-X to progress ABX-01 lead compound to first in human clinical trials

Centauri Therapeutics Limited ('Centauri'), an immunotherapy company with a unique and proprietary platform technology applicable across a wide range of therapeutic indications, announced today that CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) has provided an additional $5.1 M in funding for the development of their lead compound.

29 Jul 2025

Gut mycobiota could help predict disability in multiple sclerosis

Gut fungal communities may impact multiple sclerosis severity, offering new insights into MS pathogenesis and potential microbiome-based treatment strategies.

29 Jul 2025

What’s better for your gut: lean beef or chicken? Science weighs in

A crossover trial in healthy young adults found that both lean chicken and beef diets reduced gut microbial richness, but only chicken caused significant diversity loss. The study highlights that lean local beef may have a milder impact on the gut microbiome than chicken.

29 Jul 2025

How a leaky gut could be putting your heart at risk

Researchers reviewed recent studies showing that gut dysbiosis contributes to heart failure by weakening the gut barrier, enabling harmful metabolites like TMAO to trigger inflammation and cardiac damage. The review highlights a bidirectional “gut-heart axis” and points to new avenues for dietary and microbial therapies.

28 Jul 2025

Study maps RNA shape-shifting mechanisms in human and bacterial cells

Apart from carrying the information to encode proteins in, RNA molecules can adopt intricate 2D and 3D structures.

28 Jul 2025

Bacterial self-defense may hold clues to tackling antibiotic resistance

Researchers at the University of Southampton have worked out how bacteria defend themselves against viruses called phages and the new insights could be key to tackling antibiotic resistance.

28 Jul 2025

New swallowable sensor pill reveals gut inflammation with a simple color change

Researchers have developed an ingestible biosensor pill (PRIM) that detects intestinal inflammation by releasing a blue dye in response to elevated reactive oxygen species, providing a simple, at-home visual indicator.

27 Jul 2025

Low-gluten diets disrupt gut health by depleting key bacteria

Long-term gluten reduction may disrupt gut microbiota balance, reducing beneficial bacteria and increasing ethanol, linked to inflammation and metabolic risks.

24 Jul 2025

Gut bacteria send direct signals to the brain to stop you from overeating

Researchers have discovered a novel gut-brain sensory circuit in mice where specialized colonic cells sense bacterial flagellin and rapidly suppress feeding via the vagus nerve. This "neurobiotic sense" operates independently of immune pathways, revealing a direct neural mechanism for microbiota-host communication.

24 Jul 2025

Research uncovers a 'neurobiotic sense' that lets the brain respond to gut microbe signals

In a breakthrough that reimagines the way the gut and brain communicate, researchers have uncovered what they call a "neurobiotic sense," a newly identified system that lets the brain respond in real time to signals from microbes living in our gut.

23 Jul 2025

Oral microbiome changes explain blood pressure reduction from beetroot juice

The blood pressure lowering effect of nitrate-rich beetroot juice in older people may be due to specific changes in their oral microbiome, according to the largest study of its kind.

23 Jul 2025

Everyday diet ingredients like caffeine can affect bacterial antibiotic resistance

Ingredients of our daily diet - including caffeine - can influence the resistance of bacteria to antibiotics. This has been shown in a new study by a team of researchers at the Universities of Tübingen and Würzburg led by Professor Ana Rita Brochado.

23 Jul 2025

Deep-sea bacterial compound triggers pyroptosis to fight cancer

Promoting pyroptosis-an inflammatory form of programmed cell death-has become a promising treatment strategy for cancer.

23 Jul 2025

Probiotic bacteria found to reshape cell behavior in vitro

This study reveals how probiotic bacteria directly influence brain cell function, highlighting gut-brain communication and potential therapeutic applications.

23 Jul 2025

New insights reveal how FtsZ and ZapA cooperate during bacterial cell division

Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes.

22 Jul 2025

Restricted diet triggers drop in microbial diversity without convergence

According to a recent exploratory study published in eGastroenterology, the answer is more complex than expected. Researchers from KU Leuven and collaborating institutions conducted a tightly controlled dietary intervention, known as the "Oatmeal Study", to examine whether restricting food variety could induce convergence in the gut microbiota across individuals.

22 Jul 2025

Probiotic strains have different effects on gut recovery after antibiotics

All probiotics are not created equal, according to new research from North Carolina State University. In a mouse model, researchers found that different probiotic strains can either accelerate or delay the gut microbiome's recovery after antibiotic treatment.

21 Jul 2025

Fluorescent bacteria enable real-time tumor visualization during surgery

Accurate removal of tumors is the most critical aspect of cancer surgery, yet it remains a significant challenge in clinical practice.

21 Jul 2025

Creatine tops the list as researchers review new ways to fight osteosarcopenia

This review explores how creatine, HMB, prebiotics, and probiotics may support muscle and bone health in older adults with osteosarcopenia. While creatine shows the strongest evidence, all interventions require further research to determine their optimal use.

21 Jul 2025

AI turns old diabetes drug Halicin into a potent weapon against superbugs

Researchers found that Halicin, an AI-identified drug, effectively inhibited most multidrug-resistant bacteria except Pseudomonas aeruginosa. The study highlights Halicin’s broad-spectrum antibacterial potential and the transformative role of artificial intelligence in antibiotic discovery.

20 Jul 2025