Gene Editing News and Research

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New insights on replication-stress sensitivity in breast cancer cells

Oncotarget published "Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity" which reported that these authors recently documented that gain-of-function mutant p53 R273H in triple negative breast cancer cells interacts with replicating DNA and PARP1.

28 Jul 2021

Researchers develop ovarian tumor microenvironment-chip to test novel ways to treat the disease

In the evolving field of cancer biology and treatment, innovations in organ-on-a-chip microdevices allow researchers to discover more about the disease outside the human body.

23 Jul 2021

Study: Gene editing therapy for early-stage Huntington’s disease may have long-lasting benefits

In a new study on mice, Johns Hopkins Medicine researchers report that using MRI scans to measure blood volume in the brain can serve as a noninvasive way to potentially track the progress of gene editing therapies for early-stage Huntington's disease, a neurodegenerative disorder that attacks brain cells.

7 Jul 2021

Gene-edited cellular therapeutics can successfully treat cardiovascular and pulmonary diseases

Scientists at UC San Francisco have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases, potentially paving the way for developing less expensive cellular therapies to treat diseases for which there are currently few viable options.

6 Jul 2021

RNA-binding proteins represent a new class of drug targets for triple-negative breast cancer

In cancer research, it's a common goal to find something about cancer cells -- some sort of molecule -- that drives their ability to survive, and determine if that molecule could be inhibited with a drug, halting tumor growth. Even better: The molecule isn't present in healthy cells, so they remain untouched by the new therapy.

2 Jul 2021

ERS Genomics and Nippon Gene sign CRISPR/Cas9 license agreement

ERS Genomics Limited, which was formed to provide broad access to the foundational CRISPR/Cas9 intellectual property co-owned by Dr. Emmanuelle Charpentier, and Nippon Gene Co., Ltd (Nippon Gene), a manufacturer of genetic engineering research reagents and diagnostic reagents for humans, animals, and plants, today announced a non-exclusive license agreement granting Nippon Gene access to ERS Genomics’ CRISPR/Cas9 patent portfolio.

1 Jul 2021

Researchers develop engineered yeast probiotic for treatment of inflammatory bowel disease

The world of microbes living in the human gut can have far-reaching effects on human health. Multiple diseases, including inflammatory bowel disease (IBD), are tied to the balance of these microbes, suggesting that restoring the right balance could help treat disease.

28 Jun 2021

Olympus Wins a 2021 Edison Award for Automated Cell Culture System

Olympus is proud to announce its OLYMPUS Provi™ CM20 incubation monitoring system won a Bronze Edison Award in the Cellular Research and Disease Prevention category for its innovative design that automates the cell culture workflow.

From Evident Corporation - Life Sciences 25 Jun 2021

Study introduces a new, improved CRISPR 3.0 system in plants

In a study in Nature Plants, Yiping Qi, associate professor of Plant Science at the University of Maryland (UMD), introduces a new and improved CRISPR 3.0 system in plants, focusing on gene activation instead of traditional gene editing.

25 Jun 2021

PerkinElmer to buy SIRION Biotech

PerkinElmer Inc. agreed to buy SIRION Biotech GmbH, a provider of viral vector-based technologies that drive improved delivery performance for cell and gene therapies. The acquisition is expected to close during the third quarter of 2021.

From Revvity 24 Jun 2021

Heidelberg researchers replicate rare genetic defect in fish model

A rare genetic defect that affects the so-called ALG2 gene can cause serious metabolic diseases in humans. It does so through the defective formation of proteins and sugar molecules.

23 Jun 2021

Discovery provides new target to make melanomas more vulnerable to anti-cancer treatments

Hypoxia, or the inadequate oxygenation of a tissue, is a condition occurring frequently in all solid tumors such as melanoma skin cancer.

21 Jun 2021

Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2

A team of scientists from the University of Connecticut, USA, has developed a low-cost lab-on-paper technology to rapidly and easily detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The work has recently been published in a Royal Society of Chemistry’s Lab on a Chip journal.

18 Jun 2021

Immune cell-mimicking nanoparticles deliver drugs directly to inflamed lungs

Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. As a proof of concept, the researchers filled the nanoparticles with the drug dexamethasone and administered them to mice with inflamed lung tissue.

17 Jun 2021

Nanoparticle-based therapy alleviates pulmonary hypertension in mouse model of rare lung disease

The disease is so rare and complex that its acronym is hard to pronounce. But for infants unlucky enough to be born with this lung disease, the outcome is usually fatal.

14 Jun 2021

UCSF launches new initiative to propel the development of living therapeutics

UC San Francisco is launching a new initiative to propel the development of living therapeutics - a category of treatments broadly defined as human and microbial living cells that are selected, modified, or engineered to treat or cure disease - and bring them quickly to patients.

14 Jun 2021

Researchers develop new method to make CRISPR gene editing more precise

CRISPR Researchers from Aarhus University and University of Copenhagen have developed a new method, which makes CRISPR gene editing more precise than conventional methods.

10 Jun 2021

African cichlid fish could serve as a premier model of social disorders

Beau Alward, University of Houston assistant professor of psychology, who holds a joint appointment in biology and biochemistry and is director of the Social Neuroscience Lab, has received the Beckman Young Investigator Award by the Arnold and Mabel Beckman Foundation.

4 Jun 2021

Moffitt Cancer Center presents new data from dozens of clinical research studies at ASCO

Moffitt Cancer Center, a national leader in cancer care and research and the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida, is presenting new data from dozens of clinical research studies at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, the world's largest clinical cancer research meeting.

1 Jun 2021

New genetic editing tools could stop the spread of mosquito diseases

Since the onset of the CRISPR genetic editing revolution, scientists have been working to leverage the technology in the development of gene drives that target pathogen-spreading mosquitoes such as Anopheles and Aedes species, which spread malaria, dengue and other life-threatening diseases.

29 May 2021