Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Alkermes reports topline results from phase 2 study of ALKS 5461 drug for major depressive disorder

Alkermes plc (NASDAQ: ALKS) today announced positive preliminary topline results from a phase 2 study of ALKS 5461, its novel drug compound for major depressive disorder (MDD) in patients who have an inadequate response to standard therapies for clinical depression.

22 Apr 2013

Junk DNA plays important role in brain development

Specific DNA once dismissed as junk plays an important role in brain development and might be involved in several devastating neurological diseases, UC San Francisco scientists have found.

16 Apr 2013

REFRESH study: RP5063 shows promise for schizophrenia and schizoaffective disorder

Reviva Pharmaceuticals, Inc., a privately held drug discovery and development company, today announces top-line results from REFRESH, a phase 2 clinical trial of RP5063 for the treatment of schizophrenia and schizoaffective disorder.

10 Apr 2013

TBI can increase depression, personality impulsivity, PTSD in PNES patients

A new study by a Rhode Island Hospital researcher has found that traumatic brain injury (TBI) can significantly increase the odds of having major depression, personality impulsivity and post-traumatic stress disorder (PTSD) in patients with psychogenic nonepileptic seizures (PNES).

9 Apr 2013

Patent covering methods of treating ALS receives notice of allowance

Neuralstem, Inc. announced today that it received a notice of allowance for patent application 12/404,841. This patent covers methods for treating amyotrophic lateral sclerosis (ALS or Lou Gehrig 's disease) with expanded spinal cord stem cells, including NSI-566.

6 Apr 2013

Biological psychiatry shares progress in identifying genomic predictors of antidepressant response

Antidepressants are commonly prescribed for the treatment of depression, but many individuals do not experience symptom relief from treatment.

30 Mar 2013

Research suggests depression can increase risk of heart problems later in life

Teens who were depressed as children are far more likely than their peers to be obese, smoke cigarettes and lead sedentary lives, even if they no longer suffer from depression.

16 Mar 2013

Weill Cornell receives NIMH grant to discover novel biomarkers for chronic fatigue syndrome

Weill Cornell Medical College has been awarded more than $1.9 million by the National Institute of Mental Health of the National Institutes of Health to lead an innovative research study using advanced neuroimaging and clinical evaluations of patients with chronic fatigue syndrome (CFS).

8 Mar 2013

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

A study published in the February 2013 issue of the Journal of the American Academy of Child and Adolescent Psychiatry found that children and adolescents with major depression or subthreshold forms of bipolar disorder - and who had at least one first-degree relative with bipolar disorder - responded better to a 12-session family-focused treatment than to a briefer educational treatment.

8 Mar 2013

Fractional anisotropy examines age-related decline in cerebral white matter in schizophrenia, MDD

Many lines of evidence indicate that schizophrenia is a disorder of neurodevelopment. For example, genes implicated in the heritable risk for schizophrenia are also implicated in the development of nerve cells and their connections.

7 Mar 2013

DBS helps anorexia patients achieve and maintain improvements in body weight, mood and anxiety

In a world first, a team of researchers at the Krembil Neuroscience Centre and the University Health Network have shown that Deep Brain Stimulation (DBS) in patients with chronic, severe and treatment-resistant Anorexia Nervosa (anorexia) helps some patients achieve and maintain improvements in body weight, mood, and anxiety.

6 Mar 2013

Misdiagnosed bipolar depression has subtle clinical features

Increased appetite, sleep, and weight gain, among other clinical features, can be used to help identify patients with bipolar disorder who have been misdiagnosed with major depressive disorder.

5 Mar 2013

Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

For the first time, scientists have discovered that five major psychiatric disorders—autism, attention deficit-hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder and schizophrenia—share several common genetic risk factors.

28 Feb 2013

Patients with untreated depression are poorly protected by shingles vaccination

Results from a new study published in Clinical Infectious Diseases suggest a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine.

16 Feb 2013

Depression reduces efficacy of shingles vaccine

Research suggests that the varicella zoster, or shingles, vaccine is less effective in older people with untreated depression.

15 Feb 2013

Nightmare of insomnia could explain suicide link in patients with depression

The link between insomnia and suicidal thoughts in patients with depression may be mediated by nightmares and dysfunctional beliefs and attitudes about sleep, research suggests.

15 Feb 2013

Physical activity may reduce risk of depression in patients undergoing bariatric surgery

Adults undergoing bariatric surgery who are more physically active are less likely to have depressive symptoms and to have recently received medication or counseling for depression or anxiety than their less active counterparts, according to new research led by the University of Pittsburgh Graduate School of Public Health.

15 Feb 2013

Targacept reports net loss of $15.9 million for fourth quarter 2012

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics, today reported its financial results for the fourth quarter and year ended December 31, 2012.

14 Feb 2013

New insights on role of placebo in depression

A randomized controlled trial published in one of the last issue of Psychotherapy and Psychosomatics unravels new insights on the role of placebo in depression.

10 Feb 2013

Weekend reading: Mental health discrimination; A doctor faces hard questions; Long-term outlook for health care jobs

"When I had cancer, I got cards and flowers," Karen Kangas' sign reads. "When I was diagnosed with bipolar disorder, I got no cards and a pink slip." A picture of Kangas holding the sign hangs in the state Capitol complex, part of an exhibit called "Discrimination: A Roadblock to Recovery."

9 Feb 2013

Major Depressive Disorder News and Research

Further Reading

Alkermes reports topline results from phase 2 study of ALKS 5461 drug for major depressive disorder

Junk DNA plays important role in brain development

REFRESH study: RP5063 shows promise for schizophrenia and schizoaffective disorder

TBI can increase depression, personality impulsivity, PTSD in PNES patients

Patent covering methods of treating ALS receives notice of allowance

Biological psychiatry shares progress in identifying genomic predictors of antidepressant response

Research suggests depression can increase risk of heart problems later in life

Weill Cornell receives NIMH grant to discover novel biomarkers for chronic fatigue syndrome

Family-focused therapy improves mood symptoms in youth at risk of bipolar disorder

Fractional anisotropy examines age-related decline in cerebral white matter in schizophrenia, MDD

DBS helps anorexia patients achieve and maintain improvements in body weight, mood and anxiety

Misdiagnosed bipolar depression has subtle clinical features

Autism, ADHD, bipolar disorder, major depressive disorder and schizophrenia share common genetic risk factors

Patients with untreated depression are poorly protected by shingles vaccination

Depression reduces efficacy of shingles vaccine

Nightmare of insomnia could explain suicide link in patients with depression

Physical activity may reduce risk of depression in patients undergoing bariatric surgery

Targacept reports net loss of $15.9 million for fourth quarter 2012

New insights on role of placebo in depression

Weekend reading: Mental health discrimination; A doctor faces hard questions; Long-term outlook for health care jobs

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