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What are the current challenges and future directions of mRNA nanomedicine?

Researchers presented challenges related to the clinical translation of messenger ribonucleic acid (mRNA) technology, recent innovations and future directions to improve the clinical efficacy of mRNA nanomedicine.

15 Nov 2022

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

Researchers proposed that vaccines targeting the immunosubdominant yet conserved hemagglutinin (HA) stem could trigger broadly neutralizing antibodies (bnAbs) against influenza A viruses.

15 Nov 2022

A novel mRNA-based vaccine candidate against the rabies virus

Scientists have developed a novel mRNA-based vaccine candidate against the rabies virus. The vaccine induces a strong antibody response and exhibits high protective efficacy against lethal rabies infection in mice and dogs. A full report about the vaccine has been published in the Virology Journal.

14 Nov 2022

How mRNA vaccines work without an added adjuvant

In a recent study published in the Immunity journal, researchers explored the current knowledge of the mechanism employed by messenger ribonucleic acid (mRNA) vaccines to elicit innate immune activation.

13 Nov 2022

Well-equipped gut-friendly bacteria hold promise for improving IBD treatments

Like elite firefighters headed into the wilderness to combat an uncontrolled blaze, probiotic bacteria do a better job quelling gut inflammation when they're equipped with the best gear.

11 Nov 2022

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

A multidisciplinary team of Weill Cornell Medicine researchers have received a five-year $5.7 million grant from the National Cancer Institute at the National Institutes of Health to fund a center aimed at developing messenger RNA (mRNA) vaccines to deter cancer development in at-risk groups.

11 Nov 2022

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers developed and assessed the immunogenicity of nanoparticles expressing spike trimers from coronaviruses (CoVs).

10 Nov 2022

IVI and Lemonex sign MOU to join forces on vaccine development

The International Vaccine Institute announced on November 10 it signed a memorandum of understanding (MOU) with Lemonex, a company specializing in RNA gene therapy development, and agreed to seek cooperation in research and development.

10 Nov 2022

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes.

10 Nov 2022

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

A team from UNIGE and LMU developed a transport nanoparticle to make an anti-inflammatory drug much more effective and less toxic.

9 Nov 2022

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

In a recent study posted to the Research Square* preprint server and under review at the Nature Portfolio journal, researchers reported activation and maturation of antigen-presenting cells (APCs) by lipid nanoparticles (LNPs).

9 Nov 2022

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

Researchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines.

7 Nov 2022

A review of vaccines against the respiratory syncytial virus

This study reviewed the epidemiology, molecular characteristics, populations affected by the virus, and vaccines against RSV.

3 Nov 2022

New method to improve nanoparticle coating may enhance tumor targeting

A new technique to improve the coating of nanoparticles used in cancer therapy may enhance tumour targeting, a new study carried out in collaboration between the University of Eastern Finland and Anhui Medical University in China concludes.

31 Oct 2022

Ceria nanoparticles interfere with biological processes just like native enzymes

Bacteria love moist surfaces. Once they have settled there, they do not live as solitary organisms but form larger communities that are embedded in a protective film.

28 Oct 2022

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

A Ludwig Cancer Research study has developed a novel nanotechnology that triggers potent therapeutic anti-tumor immune responses and demonstrated its efficacy in mouse models of multiple cancers.

28 Oct 2022

OSU researchers take major step toward improving, lengthening the lives of cystic fibrosis patients

Researchers at Oregon State University and Oregon Health & Science University have taken a key step toward improving and lengthening the lives of cystic fibrosis patients, who experience chronically clogged airways and a dramatically shortened life expectancy.

27 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Two related studies, one in humans and the other in rats, found that the cardiovascular effects of cigarettes and e-cigarettes are strikingly similar, and these harmful effects on blood vessel function are likely caused by airway irritation due to inhalation of a foreign substance, rather than a specific component of the cigarette smoke or e-cigarette vapor (aerosol), according to new research published today in the American Heart Association's peer-reviewed journal Arteriosclerosis, Thrombosis and Vascular Biology.

27 Oct 2022

Long-term use of e-cigs and regular cigarettes may have damaging effects on the blood vessels

Long-term use of electronic cigarettes (e-cigs), or vaping, can significantly impair the function of the body's blood vessels, increasing the risk for cardiovascular disease.

26 Oct 2022

Nanoparticles News and Research

What are the current challenges and future directions of mRNA nanomedicine?

Hemagglutinin stem immunogens may hold the key for broad protection against influenza A viruses

A novel mRNA-based vaccine candidate against the rabies virus

How mRNA vaccines work without an added adjuvant

Well-equipped gut-friendly bacteria hold promise for improving IBD treatments

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

IVI and Lemonex sign MOU to join forces on vaccine development

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

Empty lipid nanoparticles trigger maturation and activation of antigen-presenting cells

Beyond vaccines: emerging technologies capable of unlocking the promise of biologically targeted mRNA therapeutics

A review of vaccines against the respiratory syncytial virus

New method to improve nanoparticle coating may enhance tumor targeting

Ceria nanoparticles interfere with biological processes just like native enzymes

Novel nanotechnology triggers potent therapeutic anti-tumor immune responses against multiple cancers

OSU researchers take major step toward improving, lengthening the lives of cystic fibrosis patients

Advanced type of nanoparticle could help fight hard-to-treat cancers

Studies find cardiovascular effects of cigarettes and e-cigarettes to be strikingly similar

Long-term use of e-cigs and regular cigarettes may have damaging effects on the blood vessels

Ultimate guide to the essential tools for the characterization of proteins, polymers and nanoparticles eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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