Pathophysiology News and Research

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Meta-analysis of latest second-line treatments for status epilepticus

Status epilepticus (SE) is the most common neurologic emergency, with rates estimated between 1.3 and 81 cases per 100,000 people per year.

27 May 2020

Study paves way to better understand the pathophysiology of schizophrenia

There is an extremely high probability that individuals with 22q11.2 microdeletion syndrome - a rare genetic disorder - will develop schizophrenia together with one of its most common symptoms, auditory hallucinations.

26 May 2020

Genetic discoveries show promise for developing new treatment targets for schizophrenia

In recent years, genome-wide association studies (GWAS) have identified many different genetic variants associated with schizophrenia.

22 May 2020

Canadian Glycomics Network welcomes $16.3 million renewed funding from NCE

The Networks of Centres of Excellence recently announced its continued support in Canadian glycomics research with a three-year investment of $16.3 million through the Canadian Glycomics Network (GlycoNet).

15 May 2020

Indo-Mediterranean style diets can cause decline in pre-heart failure, arrhythmias

The role of diets in the pathogenesis of cardiac dysfunction is controversial. However, it is well known that Western diet causes oxidative stress and has pro-inflammatory effects, whereas Mediterranean style diets are anti-inflammatory.

11 May 2020

Study demonstrates dynamic and broad-scale immune alterations in COVID-19 patient

A new case report released on the preprint server medRxiv* provides a detailed longitudinal analysis of the immune response associated with a fatal case of coronavirus disease (COVID-19). It highlights the need for addressing the source of hyper inflammation in the treatment approach.

10 May 2020

DFG to set up new clinical and research units

The Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) is setting up three new Research Units and one new Clinical Research Unit.

7 May 2020

Multicolor Immunohistochemistry (IHC): Going Beyond a Single Color

An interview with Dr. Will Howat at SfN 2018, discussing the possibilities and challenges of immunohistochemistry (IHC) beyond a single color!

From Abcam 1 May 2020

French scientists suggest nicotinic agonists could treat COVID-19

Contrary to the warnings issued by health agencies worldwide against cigarette smoking amid the coronavirus disease (COVID-19), a new paper suggests the possibility that nicotine, a component of tobacco, could prevent coronavirus infection.

28 Apr 2020

Fraunhofer SCAI is opening a new knowledge space with information and analysis tools on COVID-19

With the new website "covid19-knowledgespace.de", Fraunhofer SCAI - together with Fraunhofer IME, Fraunhofer IAIS, the Information Center for Life Sciences ZBMED and other research partners - is opening a new kind of knowledge space with analysis tools and information on COVID-19.

24 Apr 2020

A new, potential treatment for nonalcoholic steatohepatitis with fibrosis

In the 2020 April 21 issue of Journal of Hepatology, a research group from the Department of Hepatology in Osaka City University Graduate School of Medicine, Japan reported that a new insight into the pathophysiology of human nonalcoholic steatohepatitis (NASH) with fibrosis and suggested a possibility of the new therapy using cytoglobin (CYGB) inducer for clinical application.

21 Apr 2020

Landmark 30-year study describes clinical course of patients with Crigler-Najjar syndrome

A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome.

17 Apr 2020

COVID-19 and type 2 diabetes have shared disease pathways, study finds

Individuals with diabetes are at increased risk for bacterial, parasitic and viral infections. New research published in Endocrine Reviews, a journal of the Endocrine Society, illuminates how intersections of the coronavirus infection (COVID-19) and type 2 diabetes may require new approaches in treatment for hospitalized patients.

15 Apr 2020

Chemists identify a drug to rescue winter depression-like behavior

A group of animal biologists and chemists at the Institute of Transformative Bio-Molecules, Nagoya University, has used a chemical genomics approach to explore the underlying mechanism of winter depression-like behavior and identified a drug that rescues winter depression-like behavior in medaka fish.

13 Apr 2020