Pathophysiology News and Research

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Analysis of antioxidants, stress markers in the blood could lead to new diagnostic tool for breast cancer

A new study that analyzes levels of antioxidants and stress markers in the blood could lead to a new diagnostic tool for breast cancer. The research will be presented this week in Philadelphia at the American Physiological Society's annual meeting at Experimental Biology 2022.

2 Apr 2022

New antidiabetic substance preserves the activity of beta cells, prevents high blood glucose in mice

High blood glucose is responsible for several complications in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden have identified a new antidiabetic substance that preserves the activity of insulin-producing beta cells and prevents high blood glucose in mice.

30 Mar 2022

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Of the estimated five million patients in the U.S. diagnosed with heart failure annually, nearly half will have heart failure with preserved ejection fraction (HFpEF). Also known as diastolic heart failure, HFpEF occurs when the heart's lower left chamber loses its ability to relax and fill up with enough blood in between in each heartbeat.

23 Mar 2022

Detection of immune and clotting dysfunction in plasma and saliva after SARS-CoV-2 infection

It is becoming increasingly clear that individuals recovering from acute coronavirus disease (COVID-19) may develop post-acute sequelae (Post-Acute Coronavirus Syndrome, PACS).

23 Mar 2022

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Researchers determined the immune signature of the multisystem inflammatory syndrome in children among hospitalized children diagnosed with SARS‐CoV‐2 infection.

16 Mar 2022

Antibody treatment improves symptoms of neuromyelitis optica in a rat model

Autoimmune diseases are the molecular equivalent of "friendly fire": the body attacks itself instead of harmful invaders.

11 Mar 2022

Causal links between severe COVID-19 and blood proteins identified via proteome-wide Mendelian randomization in new study

A recent study was based on Mendelian randomization analyses conducted between high levels of numerous blood proteins and COVID-19.

9 Mar 2022

AI-ECG algorithms can enhance detection and treatment of hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden death in adolescents and initial detection is often difficult.

8 Mar 2022

Biomedical characterization of quantitative proteomics in a hospitalized cohort of COVID-19 patients

A recent study assessed neutrophil extracellular trap formation and antiviral host response in high-risk COVID-19 patients.

8 Mar 2022

Study offers insight into molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

7 Mar 2022

Targeting necroptosis using a necroptosis inhibitor lessens myositis-induced muscle weakness

A new study has suggested that treatment to target necroptosis in muscle fibers using a necroptosis inhibitor lessens myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. This has been shown to be a promising strategy for treating polymyositis.

2 Mar 2022

Vaccination reduces risk of long-COVID

A new study posted on the medRxiv* preprint server investigated the difference between the likelihood of symptoms, 12 weeks after SARS-CoV-2 infection, among individuals who received two COVID-19 vaccination doses and unvaccinated individuals.

27 Feb 2022

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

A broad evaluation of autoimmune disease-associated autoantibodies that have been observed in COVID-19 patients was performed.

22 Feb 2022

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

More than 50,000 bone marrow-derived stem cell transplants are performed worldwide each year to treat a wide range of conditions, including brain diseases.

21 Feb 2022

The impact of SARS-CoV-2 on lipids

SARS-CoV-2 appears to alter host lipid biosynthesis by relying on certain human metabolic pathways to survive and multiply effectively.

20 Feb 2022

Study characterizes brain changes in adolescents affected by juvenile fibromyalgia

Juvenile fibromyalgia is a syndrome characterized by a chronic pain affecting the whole body. It also causes fatigue as well as sleep and mood disorders.

17 Feb 2022

Frequency and function of SARS-CoV-2-specific T cells in individuals with pulmonary PASC

Researchers examined patients with pulmonary PASC of SARS-CoV-2 to determine the frequency and function of SARS-CoV-2-specific T cells in their blood.

17 Feb 2022

New Olympus Discovery Center opens to advance human disease research

Olympus is proud to announce the opening of the Olympus Discovery Center at Texas A&M Health to support research focused on treating, alleviating and preventing human diseases.

17 Feb 2022

New cell model for Alzheimer's disease could be useful in early diagnosis and testing of new therapies

Researchers at the University of Eastern Finland have developed and characterized a new cell model for Alzheimer's disease that has wide utility for research and could prove useful in early diagnosis and testing of new therapies.

16 Feb 2022

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

There is currently no effective treatment for facioscapulohumeral muscular dystrophy (FSHD), one of the most common neuromuscular diseases, which is caused by an abnormal expression of the transcription factor DUX4.

15 Feb 2022

Pathophysiology News and Research

Analysis of antioxidants, stress markers in the blood could lead to new diagnostic tool for breast cancer

New antidiabetic substance preserves the activity of beta cells, prevents high blood glucose in mice

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Detection of immune and clotting dysfunction in plasma and saliva after SARS-CoV-2 infection

Multisystem inflammatory syndrome as a late complication in COVID-19 infected children

Antibody treatment improves symptoms of neuromyelitis optica in a rat model

Causal links between severe COVID-19 and blood proteins identified via proteome-wide Mendelian randomization in new study

AI-ECG algorithms can enhance detection and treatment of hypertrophic cardiomyopathy

Biomedical characterization of quantitative proteomics in a hospitalized cohort of COVID-19 patients

Study offers insight into molecular biology of the brain in bipolar disorder patients

Targeting necroptosis using a necroptosis inhibitor lessens myositis-induced muscle weakness

Vaccination reduces risk of long-COVID

Spectrum of autoantibodies linked to autoimmune diseases in patients with different COVID-19 clinical outcomes

Researchers discover how pre-transplant chemotherapy facilitates the replacement of microglial cells

The impact of SARS-CoV-2 on lipids

Study characterizes brain changes in adolescents affected by juvenile fibromyalgia

Frequency and function of SARS-CoV-2-specific T cells in individuals with pulmonary PASC

New Olympus Discovery Center opens to advance human disease research

New cell model for Alzheimer's disease could be useful in early diagnosis and testing of new therapies

Novel promising biomarker correlates with the severity of facioscapulohumeral muscular dystrophy

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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