Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

Under stressful conditions, presence of high levels of HER2 protein causes a decrease in autophagy

Research from The Cancer Institute of New Jersey (CINJ) on biological pathways that govern progression and treatment responsiveness of HER2 positive breast cancer is being presented at the 102nd Annual Meeting of the American Association for Cancer Research (AACR) being held in Orlando this week. CINJ is a Center of Excellence of UMDNJ-Robert Wood Johnson Medical School.

6 Apr 2011

NEB, Sequenom sign deal to commercialize research tools for epigenetics

New England Biolabs, Inc. and Sequenom, Inc. jointly announce that they have signed a licensing and co-marketing agreement to commercialize research tools for epigenetics.

From New England Biolabs 6 Apr 2011

Scientists develop new method to identify factors that suppress cancer gene expression

Tumor suppressor genes normally control the growth of cells, but cancer can spring up when these genes are silenced by certain chemical reactions that modify chromosomes.

6 Apr 2011

Ubiquitine D gene may be linked to celiac disease

Celiac disease (CD) involves intolerance to gluten and, consequently, suffering chronic illness in the small intestine. It is a genetic disorder, the immunological indications of which can be traced in the human body prior to the everyday activities of future sufferers being affected. For example, persons with genetic antecedents for CD develop antibodies against the gene tTG (the enzyme known as tissue transglutaminase), even before the illness becomes active, due to a cell reaction against gluten.

5 Apr 2011

Preliminary discovery may help individualize prostate cancer screening in the future

Prostate cancer is the second leading cause of cancer-related death among American men. Yet population-wide screening programs have not reduced the number of deaths from the disease. By focusing screening programs on the men who are at greatest risk for aggressive disease or diagnosis at a young age, researchers think they could improve mortality rates and personalize the screening approach.

5 Apr 2011

Scientists suggest genetic differences in breast tissue across ethnicities

Scientists from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are working on a series of genetic analyses that suggest the underlying differences among racial groups are present not just in tumors, but in normal tissue as well. Lisa Baumbach, Ph.D., associate research professor, and colleagues will present the full study results at the AACR 102nd Annual Meeting 2011, held here April 2-6.

5 Apr 2011

New computer-based system can distinguish similar secondary tumours

A new computer-based system discussed in the International Journal of Healthcare Technology and Management can distinguish between apparently similar secondary tumours and allow a cancer specialist to trace the metastases back to the site of the original cancer in the patient's body.

5 Apr 2011

Scientists identify novel gene markers for EGFR inhibition in patients

Scientists are continuing their work on the Biomarker-integrated Approaches of Targeted Therapy for Lung Cancer Elimination trial — known more commonly as the BATTLE trial — and presented updated results at the AACR 102nd Annual Meeting 2011, held here April 2-6.

4 Apr 2011

Rsearchers define new step that controls programmed cell death in cancer cells

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death.

2 Apr 2011

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell death. In contrast to other stress-induced genes, which dispense with the regular transcriptional entourage, p21Cip1 still requires SKIP, a transcription elongation factor that also helps with the editing of transcripts, to be expressed, found researchers at the Salk Institute for Biological Studies.

2 Apr 2011

Analysis of non-tumor tissue may be an effective option for diagnosis of prostate cancer

Researchers have found that it may not be necessary to look for tumors directly in patients with prostate cancer - analyzing non-tumor tissue may be an effective option, according to study results published in Cancer Research, a journal of the American Association for Cancer Research.

1 Apr 2011

Clontech launches new SMARTer Ultra Low RNA Kit

Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced the launch of its SMARTer Ultra Low RNA Kit for Illumina Sequencing, which was developed in collaboration with Illumina, Inc.

31 Mar 2011

Master regulators of cholesterol and fat play key role in liver fibrosis development

UCLA researchers have demonstrated that a key regulator of cholesterol and fat metabolism in the liver also plays an important role in the development of liver fibrosis - the build-up of collagen scar tissue that can develop into cirrhosis. Cirrhosis, in turn, is a major cause of premature death and is incurable without a liver transplant.

31 Mar 2011

Regulus obtains exclusive rights from NYU for miR-33a, 33b to treat metabolic diseases

Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative new medicines targeting microRNAs, today announced that it has obtained exclusive rights from New York University for intellectual property covering methods of use in modulating microRNA-33a and microRNA-33b for metabolic diseases such as atherosclerosis and metabolic syndrome.

31 Mar 2011

Labcyte launches 1536-well tissue-culture treated microplate for cell-based screening

Labcyte Inc. today launched a new 1536-well tissue-culture treated microplate for cell-based screening and discovery applications. By enabling cell culture directly in a high-density microplate, this new product expands cell-based assay miniaturization capabilities, such as direct PCR from cell cultures.

30 Mar 2011

Scientists to discover new estrogen receptor-signaling networks for breast cancer treatment

The quandary of breast cancer in women is deep: the female hormone, estrogen, is considered to be a quasi-fuel for developing breast cancer.

29 Mar 2011

WaferGen launches SmartChip Human microRNA Panel V2 for gene expression profiling

WaferGen Biosystems, Inc., a leading developer of state-of-the-art genomic analysis systems, today announced the launch of its industry-leading SmartChip Human microRNA Panel V2 for gene expression profiling on the SmartChip Real-Time PCR System.

28 Mar 2011

Metagenics announces 2011 schedule for educational programs in lifestyle medicine

Metagenics Inc., a nutrigenomics and lifestyle medicine company dedicated to reducing chronic illness and improving health, announced today the 2011 schedule for educational programs in lifestyle medicine as well as for certification programs for its FirstLine Therapy, a turnkey, lifestyle medicine program.

28 Mar 2011

Biognosys brings proteomic breakthroughs to mainstream users

Biognosys, a leading provider of targeted proteomics solutions, announces the software platform mProphet for large-scale applications in industrial and academic research. The software was recently published in «Nature Methods»: With the new tool researchers can analyze complex proteomics data and generate statistically validated results.

From Biognosys 25 Mar 2011

New study implicates microRNAs in panic disorder

A new study published in the current issue of Biological Psychiatry now implicates one type of molecular switch, microRNAs, in panic disorder.

25 Mar 2011

Gene Expression News and Research

Further Reading

Under stressful conditions, presence of high levels of HER2 protein causes a decrease in autophagy

NEB, Sequenom sign deal to commercialize research tools for epigenetics

Scientists develop new method to identify factors that suppress cancer gene expression

Ubiquitine D gene may be linked to celiac disease

Preliminary discovery may help individualize prostate cancer screening in the future

Scientists suggest genetic differences in breast tissue across ethnicities

New computer-based system can distinguish similar secondary tumours

Scientists identify novel gene markers for EGFR inhibition in patients

Rsearchers define new step that controls programmed cell death in cancer cells

Loss of SKIP sensitizes cancer cells to apoptotic effects of DNA damage-inducing anticancer drugs

Analysis of non-tumor tissue may be an effective option for diagnosis of prostate cancer

Clontech launches new SMARTer Ultra Low RNA Kit

Master regulators of cholesterol and fat play key role in liver fibrosis development

Regulus obtains exclusive rights from NYU for miR-33a, 33b to treat metabolic diseases

Labcyte launches 1536-well tissue-culture treated microplate for cell-based screening

Scientists to discover new estrogen receptor-signaling networks for breast cancer treatment

WaferGen launches SmartChip Human microRNA Panel V2 for gene expression profiling

Metagenics announces 2011 schedule for educational programs in lifestyle medicine

Biognosys brings proteomic breakthroughs to mainstream users

New study implicates microRNAs in panic disorder

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