Clinical Trial News and Research

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NIAID to fund VTEU program and its companion leadership group

The National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, today announced the establishment of the Infectious Diseases Clinical Research Consortium, a clinical trials network that will encompass the Institute's long-standing Vaccine and Treatment Evaluation Units (VTEUs) and create a new consortium leadership group

20 Dec 2019

Common immune cell linked to failure of checkpoint inhibitors in lung cancer patients

For many lung cancer patients, the best treatment options involve checkpoint inhibitors. These drugs unleash a patient's immune system against their disease and can yield dramatic results, even in advanced cancers.

19 Dec 2019

Penn researchers use MRI scans to predict 10-year breast cancer recurrence

Diverse diseases like breast cancer can present challenges for clinicians, specifically on a cellular level. While one patient's tumor may differ from another's, the cells within the tumor of a single patient can also vary greatly.

19 Dec 2019

Experimental Zika vaccine improves fetal outcomes in rhesus macaque model

An experimental Zika vaccine lowered levels of virus in pregnant monkeys and improved fetal outcomes in a rhesus macaque model of congenital Zika virus infection, according to a new study in Science Translational Medicine.

19 Dec 2019

Powdered watermelon supplements provide health benefits to obese mice

Eating watermelon in the form of powdered supplements helped adult obese mice avoid some detrimental health effects of an unhealthy diet, according to a new Oregon State University study.

19 Dec 2019

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

The U.S. Food & Drug Administration granted accelerated approval to the drug enfortumab vedotin (EV) to treat adult patients with advanced urothelial or bladder cancer.

19 Dec 2019

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

19 Dec 2019

An innovative treatment for joint pain

Tired of living with painful arthritic knees, 54-year-old Deborah Brown's interest was piqued when she saw a recruitment flyer for a clinical trial on an innovative pain treatment at The University of Texas Health Science Center at Houston (UTHealth).

18 Dec 2019

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Mastectomy has historically been the standard treatment for breast cancer patients experiencing recurrence after an initial lumpectomy and whole-breast radiation. Now, a phase 2 clinical trial led by Douglas W. Arthur, M.D., chair and professor in the Department of Radiation Oncology at VCU Massey Cancer Center and VCU School of Medicine, has demonstrated an effective alternative.

18 Dec 2019

Scientists evaluate HIV/AIDS, diabetes and organ transplant drugs as possible therapies for Alzheimer's

More than ever before, Alzheimer's researchers understand that a variety of approaches will be needed - most likely used in combination - for effective treatment of the disease.

18 Dec 2019

U-M receives $20 million gift to support research and development of life-saving therapies

The University of Michigan has received a $20 million gift from the Maxine and Stuart Frankel Foundation of Bloomfield Hills, Michigan, to support the research and development of life-saving therapies at Michigan Medicine in collaboration with other institutions.

18 Dec 2019

Cancer drug shows promise in battling Parkinson’s disease

Parkinson’s disease (PD) is a lifelong condition that affects the nerve cells in the brain that produce dopamine. As a result, people with this neurodegenerative disease experience tremors, changes in speech, gait issues, and muscle rigidity. Though it has no cure, a new drug used to treat cancer shows promise in treating Parkinson’s.

17 Dec 2019

Zebrafish 'avatars' help distinguish radiosensitive from radioresistant tumors

Radiotherapy can effectively reduce or even eliminate some tumors; others, however, show enduring resistance. Considering the potentially harmful side effects of radiotherapy, clinicians agree that it is paramount to be able to determine if a patient will benefit from radiotherapy before exposing them to any of the associated risks.

17 Dec 2019

Stroke drug improves stem cell therapy in rat spinal cord injury models

Four months after treating them, Yasuhiro Shiga, MD, PhD, checked on his rats. Walking into the lab, he carried minimal expectations.

17 Dec 2019

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).

17 Dec 2019

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

A clinical trial investigating the repurposed cancer drug nilotinib in people with Parkinson's disease finds that it is reasonably safe and well tolerated.

17 Dec 2019

Type of upper airway bacteria could influence asthma severity

A new study raises the possibility of modulating asthma symptoms via the bacteria that commonly live in the upper airway. The work, which was published on December 16, 2019, in the journal Nature Communications, shows that in children who have mild to moderate asthma, the microbiome of the upper airway could determine how severe the symptoms are.

16 Dec 2019

Study suggests link between bacteria in the upper airway and asthma severity

A new study led by Washington University School of Medicine in St. Louis suggests there is a link between bacteria that live in the upper airway and the severity of asthma symptoms among children with mild to moderate asthma.

16 Dec 2019

NIH provides up to $102.5 million in renewed funding for Antibacterial Resistance Leadership Group

As antibiotic-resistant bacteria become more urgent threats worldwide, the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, will provide up to $102.5 million in renewed funding over seven years for the Antibacterial Resistance Leadership Group.

14 Dec 2019

Government insured patients with breast cancer at increased risk of death

A retrospective study of nearly 9800 women with breast cancer who participated in randomized clinical trials was presented today at the 2019 San Antonio Breast Cancer Symposium.

13 Dec 2019

Clinical Trial News and Research

NIAID to fund VTEU program and its companion leadership group

Common immune cell linked to failure of checkpoint inhibitors in lung cancer patients

Penn researchers use MRI scans to predict 10-year breast cancer recurrence

Experimental Zika vaccine improves fetal outcomes in rhesus macaque model

Powdered watermelon supplements provide health benefits to obese mice

FDA approves new drug to treat adults with advanced urothelial or bladder cancer

Researchers discover a way to move precision immunotherapy forward for multiple myeloma

An innovative treatment for joint pain

Clinical study demonstrates effective alternative to mastectomy for recurrent breast cancer

Scientists evaluate HIV/AIDS, diabetes and organ transplant drugs as possible therapies for Alzheimer's

U-M receives $20 million gift to support research and development of life-saving therapies

Cancer drug shows promise in battling Parkinson’s disease

Zebrafish 'avatars' help distinguish radiosensitive from radioresistant tumors

Stroke drug improves stem cell therapy in rat spinal cord injury models

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Study shows nilotinib drug is safe and well tolerated in patients with Parkinson's disease

Type of upper airway bacteria could influence asthma severity

Study suggests link between bacteria in the upper airway and asthma severity

NIH provides up to $102.5 million in renewed funding for Antibacterial Resistance Leadership Group

Government insured patients with breast cancer at increased risk of death

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