Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Approval for the IMAGINE trial was granted by the Austin Health Research Ethics Committee in November 2011, with the first patients dosed in March the following year. However, well before the trial was approved, PBT2 had already shown promise in significantly changing Abeta levels in spinal fluid while improving cognition in a previous 12-week trial conducted in 2006.

28 Aug 2013

Study paves way for understanding the crucial role of lncRNA in human neurons

Scientists at A*STAR's Genome Institute of Singapore have discovered an unusual gene that controls the generation of neurons. This important finding, which is crucial in understanding serious diseases of the brain such as Alzheimer's disease, was reported in the 8th August 2013 issue of the prestigious scientific journal, Molecular Cell.

28 Aug 2013

Research shows specific form of memory associations is encoded in cerebral cortex

'Where' and 'how' memories are encoded in a nervous system is one of the most challenging questions in biological research. The formation and recall of associative memories is essential for an independent life. The hippocampus has long been considered a centre in the brain for the long-term storage of spatial associations.

28 Aug 2013

Research Institute at Nationwide Children's Hospital to receive transition-to-scale grants

he Saving Lives at Birth: A Grand Challenge for Development recently shortlisted 53 finalists from around the world from more than 400 entries. Only 22 teams were awarded grants for their bold, new ideas to save the lives of mothers and newborns in developing countries.

27 Aug 2013

State highlights: Iowa asks for federal waiver for state health coverage plan

Gov. Terry Branstad filed a waiver request with federal officials on Friday, seeking expedited approval for a statewide program to expand access to health care for thousands of lower-income Iowans.

27 Aug 2013

Comprehensive test of biomarkers have prognostic and diagnostic value in Parkinson's disease

Perelman School of Medicine researchers at the University of Pennsylvania report the first biomarker results reported from the Parkinson's Progression Markers Initiative (PPMI), showing that a comprehensive test of protein biomarkers in spinal fluid have prognostic and diagnostic value in early stages of Parkinson's disease.

27 Aug 2013

Sangamo BioSciences signs definitive agreement to buy Ceregene

Sangamo BioSciences, Inc. announced that it signed a definitive agreement to acquire Ceregene, Inc., a privately held biotechnology company focused on developing adeno-associated virus gene therapies.

26 Aug 2013

Scientists identify specific type of receptor that may aid in treatment of AD, Parkinson’s disease

Scientists at Washington University School of Medicine in St. Louis have found a way that corrupted, disease-causing proteins spread in the brain, potentially contributing to Alzheimer's disease, Parkinson's disease and other brain-damaging disorders.

26 Aug 2013

Ability to draw spontaneously may be preserved in brains of artists even after vascular dementia

The ability to draw spontaneously as well as from memory may be preserved in the brains of artists long after the deleterious effects of vascular dementia have diminished their capacity to complete simple, everyday tasks, according to a new study by physicians at St. Michael's Hospital.

26 Aug 2013

Article sheds new light on differences between normal aging and Alzheimer's disease

The ability of different regions of the brain to communicate gradually breaks down with aging and in Alzheimer's disease, but there are key differences between these two processes. Some of these differences are reported in a study that compared neural networks, signaling efficiency, and disruptions in connectivity in the brains of healthy elderly subjects and patients with Alzheimer's disease.

23 Aug 2013

Board of Directors approve interim report for second quarter 2013

DiaGenic: The interim report for the second quarter 2013 was approved by the Board of Directors on 22 August 2013. Please find the interim report and presentation attached.

23 Aug 2013

Navidea Biopharmaceuticals signs SPA agreements with FDA for NAV5001 Phase 3 program

Navidea Biopharmaceuticals, Inc., a biopharmaceutical company focused on precision diagnostic radiopharmaceuticals, today announced that it has reached agreement with the U.S. Food and Drug Administration for two special protocol assessments for the Company's pivotal Phase 3 program with NAV5001 as an aid in the differential diagnosis of Parkinsonian Syndromes from non-Parkinsonian tremor.

23 Aug 2013

Psychogenics Picks Up Alzheimer’s Animal Model From USF

PsychoGenics obtained an exclusive license from the University of South Florida to its APP/PS1 double transgenic mice, which co-express the M146L presenilin 1 (PS1) mutation and the double mutations at K670N/M671L (Swedish mutation) in the amyloid precursor protein (APP).

22 Aug 2013

Chronic traumatic encephalopathy may affect people's thinking, memory, behavior and mood

New research suggests that chronic traumatic encephalopathy, a brain disease associated with repeat brain trauma including concussions in athletes, may affect people in two major ways: initially affecting behavior or mood or initially affecting memory and thinking abilities.

22 Aug 2013

LBDA creates two LBD symptom checklists for physicians and patients

The Lewy Body Dementia Association announced today the launch of new resources for physicians and their patients. LBDA created two new LBD symptom checklists; an abbreviated checklist to assist in the reporting of LBD diagnostic symptoms and a more comprehensive checklist to help people already diagnosed with LBD or their caregivers to report new or concerning LBD symptoms as the disease progresses.

22 Aug 2013

Majority of Alzheimer's researchers support disclosure of results to study participants

A leading group of Alzheimer's researchers contends that, as biomarkers to detect signals of the disease improve at providing clinically meaningful information, researchers will need guidance on how to constructively disclose test results and track how disclosure impacts both patients and the data collected in research studies.

22 Aug 2013

Biomedical spectroscopy suggests excess copper may be neurotoxic in Alzheimer's patients

Metals such as iron, copper, and zinc are important for many biological processes. In recent years, studies have shown that these nutritionally-essential metals are elevated in human Alzheimer's disease (AD) brains and some animal models of AD. Scientists are now exploring whether these metals are causing the neurodegeneration seen in AD or are indicative of other ongoing pathologic processes.

22 Aug 2013

UCLA study suggests third possible cause for AD: Iron accumulation

Alzheimer's disease has proven to be a difficult enemy to defeat. After all, aging is the No. 1 risk factor for the disorder, and there's no stopping that.

21 Aug 2013

Combination of anti-nausea drug and turmeric spice target cancer cells

In a laboratory, preclinical study recently published by the journal Organic & Biomolecular Chemistry, Virginia Commonwealth University Massey Cancer Center researchers combined structural features from anti-nausea drug thalidomide with common kitchen spice turmeric to create hybrid molecules that effectively kill multiple myeloma cells.

20 Aug 2013

D-Pharm announces promising results with drug candidates in models of HAT and malaria

D-Pharm Ltd., announced today on-line publication of promising results with its drug candidates, DP-460 and DP-b99, in models of human African trypanosomiasis (HAT) and malaria.

20 Aug 2013

Alzheimer's Disease News and Research

Further Reading

Alzheimer’s drug trial: an interview with Geoffrey Kempler, Chairman & CEO Prana Biotechnology

Study paves way for understanding the crucial role of lncRNA in human neurons

Research shows specific form of memory associations is encoded in cerebral cortex

Research Institute at Nationwide Children's Hospital to receive transition-to-scale grants

State highlights: Iowa asks for federal waiver for state health coverage plan

Comprehensive test of biomarkers have prognostic and diagnostic value in Parkinson's disease

Sangamo BioSciences signs definitive agreement to buy Ceregene

Scientists identify specific type of receptor that may aid in treatment of AD, Parkinson’s disease

Ability to draw spontaneously may be preserved in brains of artists even after vascular dementia

Article sheds new light on differences between normal aging and Alzheimer's disease

Board of Directors approve interim report for second quarter 2013

Navidea Biopharmaceuticals signs SPA agreements with FDA for NAV5001 Phase 3 program

Psychogenics Picks Up Alzheimer’s Animal Model From USF

Chronic traumatic encephalopathy may affect people's thinking, memory, behavior and mood

LBDA creates two LBD symptom checklists for physicians and patients

Majority of Alzheimer's researchers support disclosure of results to study participants

Biomedical spectroscopy suggests excess copper may be neurotoxic in Alzheimer's patients

UCLA study suggests third possible cause for AD: Iron accumulation

Combination of anti-nausea drug and turmeric spice target cancer cells

D-Pharm announces promising results with drug candidates in models of HAT and malaria

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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