Clinical Trial News and Research

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Common antibiotic appears to boost the effect of radiation on tumor cells

The antibiotic vancomycin alters the gut microbiome in a way that can help prime the immune system to more effectively attack tumor cells after radiation therapy.

9 Dec 2019

Penn researchers receive nearly $5 million to reduce opioid cravings

Opioid overdoses take the lives of tens of thousands of Americans annually. Two researchers from Penn State College of Medicine have received nearly $5 million from the National Institutes of Health to study whether an already-approved drug can be used to reduce cravings and prevent relapse in those struggling with opioid addiction.

9 Dec 2019

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

A new study by Yale Cancer Center researchers shows understanding treatment patterns for patients with acute myeloid leukemia is vital to develop strategies to improve outcomes.

9 Dec 2019

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Cancer immunology drugs, which harness the body's immune system to better attack cancer cells, have significantly changed the face of cancer treatment. People with aggressive cancers are now living longer, healthier lives. Unfortunately, cancer immunology therapy only works in a subset of patients.

9 Dec 2019

Venetoclax in combination with azacytidine aids therapy for myelodysplastic syndromes

A new study by Yale Cancer Center and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.

9 Dec 2019

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Women who receive palbociclib (Ibrance) to treat their advanced breast cancer and have a gene alteration that can lead to a condition known as benign ethnic neutropenia (BEN), can safely receive the drug without major concerns of developing infections associated with neutropenia, or low white blood cell counts, say Georgetown Lombardi Comprehensive Cancer Center researchers.

9 Dec 2019

Adding venetoclax to transplant conditioning regimen shows promise in patients with myeloid cancers

For patients with high-risk myeloid cancers undergoing a donor stem cell transplant, adding the targeted drug venetoclax to a reduced-intensity drug regimen prior to transplant is safe and does not impair the ability of the donor cells to take root in recipients' bodies, a study led by Dana-Farber Cancer Institute researchers suggests.

8 Dec 2019

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) today announced results from an extended follow-up analysis of patients in its randomized Phase 3 clinical trial, E1912.

8 Dec 2019

Innovative consortium will provide access to newest clinical trials and medical breakthroughs

New Jersey residents will have access to the newest clinical trials and medical breakthroughs as a result of an innovative consortium between Rutgers University, Princeton University and the New Jersey Institute of Technology.

8 Dec 2019

Pilot clinical trial tests new treatment for type 1 diabetes

Type 1 diabetes is a chronic condition in which the body's own immune system attacks and destroys beta cells in the pancreas. Once the beta cells are destroyed, the pancreas can no longer produce insulin. Currently, there is no cure for T1D and treatment focuses on managing blood sugar levels.

6 Dec 2019

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Patients with nonalcoholic steatohepatitis, a chronic liver disease and a leading cause for liver transplantation in the U.S., currently lack an approved drug therapy, but this may soon change.

6 Dec 2019

Shorter course of high-dose radiation treatment shows promise in breast cancer patients

A shorter course of higher-dose radiation treatment to part of the breast is showing promise in women with early-stage breast cancer who undergo breast conserving surgery, says a study led by Hamilton researchers.

6 Dec 2019

Mologic starts major clinical trial to validate point-of-care COPD exacerbation alert system

Mologic Ltd, a leading developer of lateral flow and rapid diagnostic technologies, today announced that it has started a major clinical trial to validate the Company’s urine-based multi-biomarker self-test, Headstart, for the early detection of exacerbations in patients living with moderate to severe Chronic Obstructive Pulmonary Disease .

6 Dec 2019

$Novel agent opens up new treatment option for patients with refractory myeloma$

Novel agent opens up new treatment option for patients with refractory myeloma

A novel agent called Selinexor has opened up new options for the treatment of patients with refractory myeloma. This was the conclusion of a major international clinical trial in which also the Karl Landsteiner University of Health Sciences in Krems, Austria participated.

6 Dec 2019

New analysis suggests link between cholesterol levels and long-term risk for cardiovascular disease

The most comprehensive analysis of its kind suggests that there is a strong link between non-HDL cholesterol levels and long-term risk for cardiovascular disease in people aged under 45 years, not just at older ages.

5 Dec 2019

Time-restricted eating can help treat metabolic syndrome

Metabolic syndrome affects nearly 30 percent of the U.S. population, and increases the risk for type 2 diabetes, heart disease and stroke. But lifestyle interventions such as adopting a healthy diet and increasing physical exercise are difficult to maintain and, even when combined with medication, are often insufficient to fully manage the disease.

5 Dec 2019

Drug used to treat Parkinson’s shows potential as a dementia treatment

Drug used to treat hallucinations and delusions in Parkinson's shows promise as treatment for dementia-related psychosis (DRP).

5 Dec 2019

ADDF announces new awards through its Diagnostics Accelerator initiative

The Alzheimer's Drug Discovery Foundation announced six new investments totaling $6 million through its Diagnostics Accelerator initiative.

4 Dec 2019

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Kidney cancer patients who had already tried two or three different treatments had improved chances of preventing cancer progression with an experimental drug called tivozanib compared to an alternative approved by the U.S. Food and Drug Administration, according to a City of Hope-led study.

4 Dec 2019

Common drug for nerve pain could help restore upper limb function after spinal cord injury

Long-term treatment with gabapentin, a commonly prescribed drug for nerve pain, could help restore upper limb function after a spinal cord injury, new research in mice suggests.

3 Dec 2019

Clinical Trial News and Research

Common antibiotic appears to boost the effect of radiation on tumor cells

Penn researchers receive nearly $5 million to reduce opioid cravings

Yale study highlights the need to develop effective, less toxic approaches to treat AML patients

Study shows how a new combination approach helps overcome resistance to cancer immunotherapy

Venetoclax in combination with azacytidine aids therapy for myelodysplastic syndromes

Study shows safety of palbociclib for advanced breast cancer patients with unique gene alteration

Adding venetoclax to transplant conditioning regimen shows promise in patients with myeloid cancers

Ibrutinib-based therapy provides superior clinical outcomes in majority of CLL patients

Innovative consortium will provide access to newest clinical trials and medical breakthroughs

Pilot clinical trial tests new treatment for type 1 diabetes

Clinical trial demonstrates safety and effectiveness of oral drug to treat NASH

Shorter course of high-dose radiation treatment shows promise in breast cancer patients

Mologic starts major clinical trial to validate point-of-care COPD exacerbation alert system

Novel agent opens up new treatment option for patients with refractory myeloma

New analysis suggests link between cholesterol levels and long-term risk for cardiovascular disease

Time-restricted eating can help treat metabolic syndrome

Drug used to treat Parkinson’s shows potential as a dementia treatment

ADDF announces new awards through its Diagnostics Accelerator initiative

Experimental drug better for repeat kidney cancer patients than FDA-approved equivalent

Common drug for nerve pain could help restore upper limb function after spinal cord injury

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