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Finding has major ramifications for ongoing drug development against MLL-rearranged leukemia

A massive research effort over more than a quarter century has tried to make personalized blood stem cells for use in treating leukemias, among many other uses.

17 Jan 2020

Harmful genetic mutations in healthy donors' stem cells may create problems in AML patients

A stem cell transplant - also called a bone marrow transplant - is a common treatment for blood cancers, such as acute myeloid leukemia.

16 Jan 2020

B cell count tells how certain cancers will respond to immunotherapy

Some melanomas, sarcomas and renal cell carcinomas, but not all, have been found to respond dramatically to new drugs called immune checkpoint blockers, which exploit the body’s known capability to mount an immune response against the foreign antigen-bearing tumor cells.

15 Jan 2020

HIV 'hotspots' do not necessarily fuel the epidemic

Areas of high HIV prevalence, known as 'hotspots', do not necessarily fuel the epidemic in the wider population, say researchers.

14 Jan 2020

Overactivation of neuroimmune gene leads to schizophrenia-like changes in mice

Excessive activity of an immune system gene previously linked to schizophrenia reproduces neural and behavioral aspects of the disease in mice, according to a new study publishing on January 14 in the open-access journal PLOS Biology by Ashley Comer and Alberto Cruz-Martín of Boston University and colleagues.

14 Jan 2020

New tool could speed up neuroscience research into pheromones

Researchers at Worcester Polytechnic Institute have developed a tool to identify molecular receptors in worms that are involved in sensing pheromones related to mating, an advance that could speed up neuroscience research into pheromones by eliminating months of work.

14 Jan 2020

Bath scientists identify promising route to develop new treatments for skin cancer

A promising route to develop new treatments for skin cancer has been identified by University of Bath scientists, who have found a molecule that suppresses melanoma tumor growth.

14 Jan 2020

CHOP-led study reveals how genetic variations can influence variety of common diseases

While subtle differences in the number of genes copied from one individual and passed down to the next can be found in many healthy people, their role in disease may be much greater than previously thought.

14 Jan 2020

ERS Genomics signs licensing agreement with Daiichi Sankyo

ERS Genomics today announced the signing of a license agreement with Daiichi Sankyo, a global pharmaceutical company with corporate origins in Japan.

14 Jan 2020

Horizon Discovery to offer novel base editing technology for clinical research

Horizon Discovery today announced that it will provide access to a novel base editing technology licensed from Rutgers for exclusive use in therapeutic, diagnostic and services applications.

From Revvity 14 Jan 2020

New computer algorithm enables prediction of gestational diabetes

A new computer algorithm enables prediction, in the early stages of pregnancy or even before pregnancy has occurred, of which women are at a high risk of gestational diabetes.

13 Jan 2020

Researchers identify new pathway as biological target for colon cancer

Researchers have found a way to help make chemotherapy more effective in treating colon cancer. They identified a new pathway (RICTOR/mTORC2) as a biological target for the disease.

13 Jan 2020

The International Consortium Claims Medical Breakthrough in Malaria Research

An international consortium led by researchers in Sweden and Switzerland has conducted a genome-wide study that the team is calling a “medical breakthrough” in malaria research.

13 Jan 2020

Genes determining the browning of white fat finds study

The fat cells of the body play an essential role in the storage of energy and its release when necessary. Research has shown that apart from energy storage, these adipocytes or fat cells also play a role in hormonal balance and metabolism-regulating hunger. A new study titled, “Systems-genetics-based inference of a core regulatory network underlying white fat browning”, was published in the latest issue of the journal Cell Report.

13 Jan 2020