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Study lays foundation for translating mitochondrial biology into clinical applications

A study led by The University of Texas MD Anderson Cancer Center furthered understanding about mitochondria, the cell components known as the "powerhouse of the cell." Knowing more about the genome is crucial given that mitochondria play important roles in tumorigenesis.

6 Feb 2020

Researchers discover new mutational phenomenon chromothripsis in cancer

Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.

6 Feb 2020

New insight into genomic alterations associated with telomere maintenance mechanisms in cancer

To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various different ways.

6 Feb 2020

Analyzing cancer-specific alterations found in tumor's RNA

Researchers at EMBL-EBI were among the leaders of a large international consortium that carried out a joint analysis of data from over 1000 donors of more than 25 cancer types, studying data on their whole genomes along with tumor transcriptome data, which indicates the genes that are active within a tumor.

6 Feb 2020

Researchers study how structural variations in the genome can lead to cancer

Structural variations in genomes can arise from deleting, amplifying, or reordering genomic segments ranging from a few thousand letters of the genetic code to whole chromosomes.

6 Feb 2020

First comprehensive survey of viruses found within different cancers

Researchers from the University of East Anglia have helped to carry out the first comprehensive survey of viruses found within different types of cancer.

5 Feb 2020

Cancer mutations may arise decades before diagnosis

Researchers at EMBL's European Bioinformatics Institute and the Francis Crick Institute have analyzed the whole genomes of over 2600 tumors from 38 different cancer types to determine the chronology of genomic changes during cancer development.

5 Feb 2020

Researchers discover new genetic drivers of cancer

The discovery of genetic drivers of cancer can have critical implications for the diagnosis and treatment of cancer patients, yet genome analysis has focused primarily on only 1-2% of the whole genome - the part that contains the code for making proteins.

5 Feb 2020

Study sheds new light on genetic relationship between three mood disorders

Researchers shed new light on the genetic relationship between three mood disorders associated with depression--major depression and bipolar disorder types 1 and 2, in a new study in the journal Biological Psychiatry, published by Elsevier.

5 Feb 2020

Prenatal single cell blood test for gene defects

With the current state of knowledge regarding genetic testing, non-invasive prenatal testing (NIPT) is in favor for genetic testing in unborn babies, using fragments of DNA circulating in the mother’s blood.

4 Feb 2020

RNA affecting skin cancer progression discovered

Researchers at the University of Turku, Turku University Central Hospital, and Western Cancer Center have discovered a new RNA molecule, PRECSIT, which regulates the growth and invasion of squamous cell carcinoma of the skin.

4 Feb 2020

Single-cell DNA assessment method can detect fetal genetic abnormalities

Non-invasive prenatal tests are used for fetal genetic disease screening in pregnant women. In contrast, invasive tests like amniocentesis carry the risk of causing fetal harm.

4 Feb 2020

New technology provides point of care insights to Rush oncologists

Rush University Medical Center is the first health care organization to launch medical record company Epic's module for genomic results, giving providers the tools they need to tailor patient care at the molecular level.

4 Feb 2020

Researchers discover fundamental mechanism that regulates gene activity in cells

Researchers at Johns Hopkins Bloomberg School of Public Health have discovered a fundamental mechanism that regulates gene activity in cells.

4 Feb 2020

Measuring 'stickiness' of cancer cells could improve prognostic evaluation of tumors

A team of researchers led by the University of California San Diego has created a device that measures how "sticky" cancer cells are, which could improve prognostic evaluation of patient tumors. The device is built with a microfluidic chamber that sorts cells by their physical ability to adhere to their environment.

3 Feb 2020