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Specific variant of the HLA-DPB1 gene linked with poor response to allergen immunotherapy

Although sublingual immunotherapy (SLIT) has become an effective treatment option for many allergies, about 20-30% of patients don’t respond to SLIT for Japanese cedar pollinosis–a highly common disease.

7 Mar 2022

World Trade Center responders have increased levels of mutations that escalate blood cancer risk

Scientists from Vanderbilt-Ingram Cancer Center (VICC) collaborated with researchers from New York to determine that 9/11 first responders to the World Trade Center have increased levels of mutations that escalate their risk for blood cancers or cardiovascular disease, according to a study published March 7 in Nature Medicine.

7 Mar 2022

Study explores differentially expressed immune genes for COVID-19 patient stratification

In a new study, researchers determined the transcriptional signatures associated with the severity of COVID-19.

7 Mar 2022

Common rapid antigen tests detect Delta and Omicron SARS-CoV-2 strains effectively

A recent study by US researchers shows how the performance of rapid antigen tests to diagnose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not inferior among individuals infected with the Omicron variant compared to the Delta variant. The study is currently available on the medRxiv* preprint server while it undergoes peer review.

7 Mar 2022

Diabetes and the mTOR pathway in COVID-19 patients

A new study discusses the possible etiopathogenetic mechanisms associated with diabetes that could enhance the severity of COVID-19.

6 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

A recent study explores the effect of sleep and circadian rhythm dispersion on mouse lung transcriptome after six of hours sleep deprivation.

6 Mar 2022

New technique can upregulate specific genes without permanently altering the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

6 Mar 2022

Cell-hobbling fibrils found across diverse neurodegenerative diseases

Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.

4 Mar 2022

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

A new DNA test, developed by researchers at the Garvan Institute of Medical Research in Sydney and collaborators from Australia, UK and Israel, has been shown to identify a range of hard-to-diagnose neurological and neuromuscular genetic diseases quicker and more-accurately than existing tests.

4 Mar 2022

Researchers discover functional links between potassium channel gene variants and neonatal epilepsy

Northwestern Medicine scientists have discovered functional links between dozens of potassium channel gene variants and neonatal epilepsy, according to a study published in JCI Insight.

4 Mar 2022

A new method to produce complex natural products in amoebae

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute in Jena, Germany has developed a new method to produce complex natural products in amoebae.

4 Mar 2022

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

A high-fat diet is not enough to cause short-term fatty liver disease. However, if this diet is combined with the intake of beverages sweetened with liquid fructose, the accumulation of fats in the liver accelerates and hypertriglyceridemia —a cardiovascular risk factor— can appear.

4 Mar 2022

Potential molecular and clinical biomarkers of COVID-19 severity

Researchers have reviewed the currently published data examining the potential molecular and clinical biomarkers of COVID-19 severity.

4 Mar 2022

Researchers discover a nuclear import mechanism essential for organ growth and development

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have identified a nuclear import mechanism essential for organ growth and development. Manipulation of this mechanism has potential applications in the control of organ growth and organ regeneration.

4 Mar 2022

Genes News and Research

Specific variant of the HLA-DPB1 gene linked with poor response to allergen immunotherapy

World Trade Center responders have increased levels of mutations that escalate blood cancer risk

Study explores differentially expressed immune genes for COVID-19 patient stratification

Common rapid antigen tests detect Delta and Omicron SARS-CoV-2 strains effectively

Diabetes and the mTOR pathway in COVID-19 patients

Combating COVID cytokine storm with targeted nucleic acid therapies

Disruption of sleep and circadian rhythm can increase the chances of contracting a virus

New technique can upregulate specific genes without permanently altering the genome

Cell-hobbling fibrils found across diverse neurodegenerative diseases

New DNA test can quickly and accurately identify a range of hard-to-diagnose genetic diseases

Researchers discover functional links between potassium channel gene variants and neonatal epilepsy

A new method to produce complex natural products in amoebae

High-fat diet combined with liquid fructose intake accelerates fat accumulation in the liver

Potential molecular and clinical biomarkers of COVID-19 severity

Researchers discover a nuclear import mechanism essential for organ growth and development

Patterns of bat β-coronaviruses evolution

Using oral blood pressure drug to treat Type 1 diabetes shows benefits for at least two years

Study shows targeting DDX3 with RK-33 reduced the viral load in four isolates of SARS-CoV-2

Whole-genome sequencing project sheds new light on the diversity of Candida glabrata

Assessing the potential of IFNa subtypes in suppressing SARS-CoV-2

eBook: Using iPSCs models for human disease research and drug discovery eBook

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