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Mount Sinai study identifies potential new treatment target for aggressive bladder cancer

A potential new target for treatment has been identified in an aggressive form of bladder cancer, Mount Sinai researchers report.

4 Jul 2018

Mayo researchers determine how DNA repair protein gets to the site of damage

Damage to DNA is a daily occurrence but one that human cells have evolved to manage. Now, in a new paper published in Nature Structural & Molecular Biology, Mayo researchers have determined how one DNA repair protein gets to the site of DNA damage. The authors say they hope this discovery research will help identify new therapies for ovarian cancer.

3 Jul 2018

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

Focal malformations of cortical development are a heterogeneous group of brain cortical abnormalities.

2 Jul 2018

New biomarker paves way for personalized bladder cancer treatments

Researchers have identified a potential new target for the treatment of a particularly aggressive form of bladder cancer, in the form of microRNA.

2 Jul 2018

Clinical judgment of doctors not reliable to predict MRH in older adults post-hospital discharge

Medication-related harm is common in older adults following hospital discharge. A new British Journal of Clinical Pharmacology study has examined whether doctors can predict which older patients will experience MRH requiring care following hospital discharge, and whether clinical experience and confidence in prediction influence the accuracy of predictions.

2 Jul 2018

Antioxidant-enriched vitamin may decrease exacerbations in cystic fibrosis patients

An antioxidant-enriched vitamin may decrease respiratory exacerbations in people with cystic fibrosis(CF), according to new research published online in April in the American Journal of Respiratory and Critical Care Medicine.

2 Jul 2018

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells.

30 Jun 2018

Duke Regional Hospital implements Glytec's eGMS to personalize insulin therapy

With national statistics indicating that one of every three hospitalized patients requires insulin therapy during their stay, administering the right dose at the right time in accordance with best practices is integral to safe, effective care and speedy recovery

30 Jun 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

New therapeutic may help drug addicts avoid future drug use

A new therapeutic may help reverse chemical imbalances made to the brain by habitual drug use and could one day help recovering drug addicts avoid future drug use.

30 Jun 2018

Modified natural killer cells may be new player in CAR-T immunotherapies

Emerging CAR-T immunotherapies leverage modified versions of patient's T-cells to target and kill cancer cells.

29 Jun 2018

New mouse model could shed light on autism subtype

Researchers at the UC Davis MIND Institute have created a mouse model for maternal antibody- related (MAR) autism spectrum disorder that closely mimics the physiology and behaviors seen in people with this form of ASD.

29 Jun 2018

Survey: Psoriasis patients may face a long journey to achieve goal of clear skin

Novartis announced today the publication of global Clear about Psoriasis survey data in the Journal of the European Academy of Dermatology and Venereology. The publication highlights that despite clear or almost clear skin being more achievable than ever before, patients may face a long journey to attain this reality.

From Novartis 29 Jun 2018

Researchers reveal complexity of NMDA receptor drug discovery target

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression.

28 Jun 2018

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

A DNA-level biomarker (MGMT promoter methylation) can be used to help predict survival outcomes in patients with high-risk, low-grade gliomas, according to a new study conducted through the NRG Oncology/RTOG collaborative clinical trials group and led by scientists at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

28 Jun 2018

Geriatric assessments could fine-tune cancer care for older adults

In a move to improve cancer care for older adults, the American Society of Clinical Oncology is recommending that all patients age 65 and older receive a geriatric assessment when considering or undergoing chemotherapy.

28 Jun 2018

Researchers develop new approach for studying Cryptosporidium in healthy human tissues

Washington State University researchers have developed a new approach for studying Cryptosporidium, a waterborne gastrointestinal parasite now recognized as one of the leading causes of potentially life-threatening diarrheal disease in young children worldwide.

26 Jun 2018

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

A genetically modified poliovirus therapy developed at Duke Cancer Institute shows significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent in a phase 1 clinical trial.

26 Jun 2018

New nuclear medicine approach shows potential for precision treatment of solid tumors

A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children.

26 Jun 2018

Researchers discover immune profile for effective cancer immunotherapy

In a new study published online June 25, 2018 in Nature Medicine, UC San Francisco researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs known as checkpoint inhibitors.

25 Jun 2018

Therapeutics News and Research

Mount Sinai study identifies potential new treatment target for aggressive bladder cancer

Mayo researchers determine how DNA repair protein gets to the site of damage

Researchers identify molecular mechanism leading to cortical malformation from brain-only mutations

New biomarker paves way for personalized bladder cancer treatments

Clinical judgment of doctors not reliable to predict MRH in older adults post-hospital discharge

Antioxidant-enriched vitamin may decrease exacerbations in cystic fibrosis patients

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Duke Regional Hospital implements Glytec's eGMS to personalize insulin therapy

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

New therapeutic may help drug addicts avoid future drug use

Modified natural killer cells may be new player in CAR-T immunotherapies

New mouse model could shed light on autism subtype

Survey: Psoriasis patients may face a long journey to achieve goal of clear skin

Researchers reveal complexity of NMDA receptor drug discovery target

Genetic biomarker can help predict survival outcomes in patients with certain gliomas

Geriatric assessments could fine-tune cancer care for older adults

Researchers develop new approach for studying Cryptosporidium in healthy human tissues

Phase 1 clinical trial of poliovirus therapy shows long-term survival benefit for recurrent glioblastoma

New nuclear medicine approach shows potential for precision treatment of solid tumors

Researchers discover immune profile for effective cancer immunotherapy

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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