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Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States demonstrated that the acidic milieu of the nasal cavity is critical for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism.

14 Jun 2022

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

A new study published in the journal Reports focused on the hijacking of the pancreatic, endothelial, and gut GABA by SARS-CoV-2 and its associated pathology along with interventions.

10 Jun 2022

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

In a recent study posted to the medRxiv* pre-print server, researchers in the United Kingdom investigated the effect of two Pfizer/BioNTech BNT162b2 vaccine doses or Oxford/AstraZeneca AZ1222 coronavirus disease 2019 (COVID-19) vaccination and a subsequent BNT162b2 booster dose in a cohort of healthcare workers (HCWs) over six to nine months.

10 Jun 2022

Research suggests two protein coding genes can predict severe COVID-19

In a recent study posted to the medRxiv* pre-print server, researchers demonstrated that two genes, GTPase, IMAP Family Member 7 (GIMAP7), and sphingosine-1-phosphate receptor 2 (S1PR2), have the potential to predict severe coronavirus disease 2019 (COVID-19) with ~90% accuracy.

8 Jun 2022

Can dogs accurately detect COVID-19?

Researchers evaluate the accuracy of using dogs to smell and identify the presence of SARS-CoV-2 in infected and non-infected individuals.

6 Jun 2022

New findings reveal potential mechanisms for cellular defects in human laminopathies

A Northwestern Medicine study has uncovered distinct roles for major nuclear lamin isoforms in maintaining intracellular interactions and cellular mechanics, according to findings published in the Proceedings of the National Academy of Sciences.

1 Jun 2022

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Researchers identified a single viral gene product, the accessory factor ORF7a, facilitating SARS-CoV-2 immune evasion by downregulating the surface expression of MHC class I molecules.

1 Jun 2022

Effectiveness of copper nanoparticle-based spray coating against SARS-CoV-2

Researchers demonstrate how copper NPs can potentially be incorporated into filters, PPE, facemasks, and clothing to effectively inactivate SARS-CoV-2.

31 May 2022

2-Deoxy-D-glucose may inhibit coronaviruses and rhinoviruses

Scientists demonstrated the use of 2-deoxy-D-glucose (2-DG) as a wide-spectrum antiviral agent targeting viruses such as SARS-CoV-2.

27 May 2022

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Researchers reviewed available mucosal vaccines discussing the current challenges and ways to advance the existing approaches.

25 May 2022

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers observed SARS-CoV-2 downregulates the expression of MHC class I molecules.

23 May 2022

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical.

20 May 2022

Epistatic drift leads to unpredictability in protein evolution

A critical goal in genetics and evolution is predicting the effects of mutations that may happen in the future and inferring the effects of those that happened in the past.

19 May 2022

SARS-CoV-2 Omicron found to be more immune evasive than other variants among mild COVID-19 convalescent patients

Researchers evaluated the humoral and T lymphocyte immune responses against SARS-CoV-2 variants of concern among mild COVID-19 convalescent patients in South Australia.

19 May 2022

Study explores polyfunctionality of BNT162b2 COVID-19 vaccine-induced memory T-cells

Researchers assessed the impact of the BNT162b2 SARS-CoV-2 vaccine-induced memory T cells on the SARS-CoV-2 Omicron variant.

19 May 2022

Researchers examine link between long-term use of blood pressure drugs and breast cancer risk

Curtin University researchers will examine if the long-term use of a popular blood pressure medication increased the risk of breast cancer in almost 200,000 women as part of a new project supported by the Federal Government.

19 May 2022

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Researchers compared the immunogenicity of or and reactogenicity to the BNT162b2 vaccine in Japanese adults and elders.

16 May 2022

An Ad5 vectored COVID vaccine expressing an S1-N fusion protein

In a recent study posted to the bioRxiv* preprint server, researchers characterized the development of multiple adenovirus-vectored and subunit recombinant protein severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates.

12 May 2022

Clonality and magnitude of SARS-CoV-2-reactive CD4+ T cells in COVID-19 convalescent patients after vaccination

A new study has focussed on determining the clonality and levels of SARS-CoV-2-reactive CD4+ T cells in CCPs post-vaccination.

12 May 2022

The promise of RNA medicine is targeted and personalized

The development of messenger RNA (mRNA) vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has only increased the impetus in this field.

11 May 2022

Intracellular News and Research

Molecular snapshots of the productive infectious entry pathway of SARS-CoV-2 into cells

Association of neuronal and non-neuronal GABA with neuropsychiatric illness in COVID-19 patients

Study reports robust immunity to SARS-CoV-2 including Omicron BA.1 for all three primary vaccines

Research suggests two protein coding genes can predict severe COVID-19

Can dogs accurately detect COVID-19?

New findings reveal potential mechanisms for cellular defects in human laminopathies

Study shows the SARS-CoV-2 accessory protein ORF7a inhibits HLA-I surface expression levels in human cells

Effectiveness of copper nanoparticle-based spray coating against SARS-CoV-2

2-Deoxy-D-glucose may inhibit coronaviruses and rhinoviruses

Review addresses the need for innovative adjuvant approaches and delivery strategies for the advancement of new mucosal vaccines

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Epistatic drift leads to unpredictability in protein evolution

SARS-CoV-2 Omicron found to be more immune evasive than other variants among mild COVID-19 convalescent patients

Study explores polyfunctionality of BNT162b2 COVID-19 vaccine-induced memory T-cells

Researchers examine link between long-term use of blood pressure drugs and breast cancer risk

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

An Ad5 vectored COVID vaccine expressing an S1-N fusion protein

Clonality and magnitude of SARS-CoV-2-reactive CD4+ T cells in COVID-19 convalescent patients after vaccination

The promise of RNA medicine is targeted and personalized

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