Organoids News and Research

RSS

Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

UA researchers aim to predict and prevent fatal disease in premature babies

A new $1.9 million grant at the University of Arizona Steele Children's Research Center will help researchers discover ways to prevent a deadly disease that affects thousands of premature infants annually.

25 Apr 2018

Salk researchers develop new glioblastoma model using gene-edited organoids

Glioblastoma multiforme (GBM) is an incredibly deadly brain cancer and presents a serious black box challenge. It's virtually impossible to observe how these tumors operate in their natural environment and animal models don't always provide good answers.

25 Apr 2018

New 'lymphoma micro-reactor' device targets chemo-resistant tumors

Non-Hodgkin lymphoma, a cancer that is diagnosed in the U.S. more than 70,000 times annually, arises from overly proliferating immune cells within the body's lymph nodes, which are connected to a network of lymph vessels through which lymphatic fluid flows.

12 Apr 2018

New technique makes it possible to trace lineage of each cell

Every biology textbook states that cells are life's building blocks. But researchers are only now beginning to understand their diversity. Technologies such as RNA sequencing are revealing which genes are expressed in each individual cell.

9 Apr 2018

Scientists create organoids that could help guide bladder cancer treatment

Researchers have created patient-specific bladder cancer organoids that imitate many of the features of real tumors and may therefore be used to study how cancer evolves.

6 Apr 2018

Live-cell imaging capabilities of the InVi SPIM microscope announced by Luxendo

Luxendo, a Bruker company, today announced the extension of the InVi SPIM microscope to include full incubation capabilities, as well as flexible illumination and detection optics.

From Bruker 28 Mar 2018

Researchers identify salivary protein that protects the body from traveler's diarrhea

Researchers have identified a protein in saliva (histatin-5) that protects the body from traveler's diarrhea.

8 Mar 2018

Researchers describe important step toward gene therapy for patients with Sandhoff disease

Babies with the rare, deadly genetic disorder Sandhoff disease begin to miss developmental milestones just months after birth. Lacking muscle tone, they never learn to sit up, develop heads too large to lift and eventually suffer uncontrollable seizures. There is no cure.

22 Feb 2018

Tiny 'brains on chips' reveal mechanisms underlying brain's wrinkling process

Being born with a "tabula rasa" - a clean slate - in the case of the brain is something of a curse. Our brains are already wrinkled like walnuts by the time we are born. Babies born without these wrinkles - smooth brain syndrome - suffer from severe developmental deficiencies and their life expectancy is markedly reduced.

20 Feb 2018

Organ chip technology improves study of the intestine for personalized medicine

Researchers have developed an organ-on-a-chip device using donor-derived human intestinal cells that offers advantages over organoids and new possibilities for personalized medicine.

14 Feb 2018

Researchers develop most sophisticated mini-livers to date

Scientists at Wake Forest Institute for Regenerative Medicine have developed the most sophisticated mini-livers to date.

13 Feb 2018

Researchers grow hairy skin using mouse stem cells

Indiana University School of Medicine researchers have cultured the first lab-grown skin tissue complete with hair follicles.

3 Jan 2018

Macrophages play major role in helping early breast cancer cells spread even before tumor develops

Mount Sinai researchers have discovered that normal immune cells called macrophages, which reside in healthy breast tissue surrounding milk ducts, play a major role in helping early breast cancer cells leave the breast for other parts of the body, potentially creating metastasis before a tumor has even developed, according to a study published in Nature Communications.

2 Jan 2018

Researchers generate 3D cell cultures to investigate mechanisms of drug resistance in breast cancer

An international research team headed by the University of Bern and the Netherlands Cancer Institute has developed 3D cell cultures in which genes can be specifically modified. They allow the study of genes that may cause therapy resistance in breast cancer.

11 Dec 2017

3D mini brains put researchers on a fast track to repair the nervous system

The Houston Methodist Research Institute is making mini brains from human stem cells that put researchers on a fast track to repair the nervous system after injury or disease of the brain and spinal cord.

8 Dec 2017

CLOCK gene plays key role in regulating many genes important to brain evolution

Scientists have long sought to unravel the molecular mysteries that make the human brain special: What processes drove its evolution through the millennia? Which genes are critical to cognitive development?

6 Dec 2017

New study describes unique bioengineered tissue construct for modeling colorectal cancer

A new study describes a unique bioengineered tissue construct, or organoid, into which colorectal cancer cells are embedded, creating a model of the tumor and surrounding extracellular matrix.

6 Dec 2017

Immunologist focuses on initial stages of infection to fight against HIV

In a project funded by the Austrian Science Fund FWF, Doris Wilflingseder investigates the initial stages of infection - the time span when the immune system might still stop HIV.

28 Nov 2017

Drug used to prevent and treat malaria may also be effective for Zika virus

A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika virus.

17 Nov 2017

Human brain organoids in the making amidst ethical concerns

Scientists from Vienna have worked for four years and finally come up with a small blob of human brain tissue that has been created from stem cells. These human brain organoids as they are called, are capable of pulsing with electrical activity and also create new nerve cells or neurons.

8 Nov 2017