Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Mass spectrometry-based tool successfully used in brain cancer surgery

A tool to help brain surgeons test and more precisely remove cancerous tissue was successfully used during surgery, according to a Purdue University and Brigham and Women's Hospital study.

4 Jul 2014

Loss of p62 protein in cells and tissue surrounding a tumor can influence tumor growth

A team of scientists from Sanford Burnham Medical Research Institute has found that the loss of a protein called p62 in the cells and tissue surrounding a tumor can enhance the growth and progression of tumors.

4 Jul 2014

Galderma's trifarotene molecule gets FDA Orphan Drug Designation for treatment of congenital ichthyosis

Galderma announces that the U.S. FDA granted Orphan Drug Designation status for the company's trifarotene molecule for the treatment of congenital ichthyosis. Based on this decision, Galderma plans to implement a clinical development plan, reinforcing its commitment to exploring new treatment options for rare diseases, as well as meeting the needs of all patients with skin diseases over the course of their lives.

2 Jul 2014

Researchers receive over $1M to study molecular foundations of pancreatic cancer

Alexandros Tzatsos, M.D., Ph.D., assistant professor of anatomy and regenerative biology at the George Washington University School of Medicine and Health Sciences, was awarded over one million dollars in grants from the National Institutes of Health to study the molecular foundations of pancreatic cancer.

1 Jul 2014

Focal choroidal excavation’s coexistence with other choroidal diseases impairs vision

Focal choroidal excavation appears to be relatively common and can have a detrimental effect on vision, a study of Korean patients suggests.

1 Jul 2014

Researchers identify new protein as possible therapeutic target for pancreatic cancer

Researchers from IMIM (Hospital del Mar Medical Research Institute) have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer.

1 Jul 2014

Synthetic Biologics supports SYN-004 C.difficile preventative program with formation of Clinical Advisory Board

Synthetic Biologics, Inc., a developer of novel anti-infective biologic and drug candidates targeting specific pathogens that cause serious infections and diseases, announced today the formation of a Clinical Advisory Board (CAB) to support development of SYN-004, the Company's lead anti-infective product candidate for the prevention of the devastating effects of Clostridium difficile (C. difficile)

30 Jun 2014

Outpatient hysteroscopy before IVF doesn't seem to improve IVF results

A large multicentre trial seems finally to have resolved one of IVF's long-running controversies - whether the outlook for women with a poor IVF record can be improved by routine hysteroscopy performed before further IVF treatment.

30 Jun 2014

EMA CHMP recommends marketing authorization for GE's VIZAMYL for PET imaging to detect beta amyloids

GE Healthcare today announced the receipt of a positive opinion from the European Medicines Agency's Committee for Medicinal Products for Human Use. This opinion recommends the granting of a marketing authorisation for VIZAMYL (Flutemetamol F18 injection), a radiopharmaceutical medicinal product indicated for Positron Emission Tomography imaging of beta amyloid neuritic plaque density in the brains of adult patients with cognitive impairment who are being evaluated for Alzheimer's disease and other causes of cognitive impairment.

30 Jun 2014

Non-Hodgkin lymphoma subgroups found to have different survival rates

A Mayo Clinic-led group of researchers has discovered three subgroups of a single type of non-Hodgkin lymphoma that have markedly different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of novel genetic tests, which the research team recommends giving to all patients with ALK-negative anaplastic large-cell lymphoma (ALCL). Findings are published in the journal Blood.

27 Jun 2014

Administering low doses of thyroid hormone to rats with diabetes prevents deterioration of heart function

Administering low doses of a thyroid hormone to rats with diabetes helps restore hormone levels in their hearts and prevented deterioration of heart function and pathology, according to a new study by NYIT College of Osteopathic Medicine Professor and Biomedical Sciences Chair A. Martin Gerdes.

26 Jun 2014

Combination of MRI and PET imaging techniques can prevent second breast biopsy

Following a diagnosis of breast cancer, one of the hardest tasks is to distinguish the benign nodes in the breast from the malignant tumours, and this usually requires a tissue sample (biopsy) to be taken.

26 Jun 2014

Frederic Bushman gets Pioneer Award from Human Gene Therapy

Frederic D. Bushman, PhD's (University of Pennsylvania Perelman School of Medicine) early pioneering work in understanding how HIV reproduces by inserting its genetic material into the DNA of a host cell led to key advances in the ability to move pieces of DNA and whole genes between cells.

25 Jun 2014

BioLineRx announces in-licensing of BL-1110 compound for treatment of neuropathic pain

BioLineRx Ltd., a clinical-stage biopharmaceutical company dedicated to identifying, in-licensing and developing promising therapeutic candidates, announced today it has in-licensed BL-1110, a novel compound for the treatment of neuropathic pain.

23 Jun 2014

Definiens closes €15M financing round to expand into digital tissue diagnostics

Definiens AG, which offers a unique approach to tissue diagnostics aimed at helping physicians improve treatment, said that it has closed a round of financing for € 15 million.

23 Jun 2014

National, state air pollution controls decrease death rates in North Carolina

National and state air pollution controls that went into effect in the early 1990s coincide with decreasing death rates from emphysema, asthma and pneumonia among people in North Carolina, according to a study led by Duke University researchers.

23 Jun 2014

Chinese FDA accepts Lee's IND for Phase 2 dry eye study

RegeneRx Biopharmaceuticals, Inc. and Lee's Pharmaceutical Holdings Ltd. today jointly announced that the Chinese FDA has accepted a Phase II IND for RGN-259 (thymosin beta 4-based, preservative-free eye drops) to be tested in patients with moderate to severe dry eye syndrome in China.

23 Jun 2014

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Pancreatic cancer tumors addicted to mutant Kras signaling for their growth and progression have a ready-made substitute to tap if they're ever forced to go cold-turkey on the mutant oncogene, scientists at The University of Texas MD Anderson Cancer Center report in the journal Cell.

20 Jun 2014

Schizophrenia focus narrowed to dentate gyrus

The dentate gyrus is a likely site of pathology underlying schizophrenia, shows a study published in Molecular Psychiatry.

19 Jun 2014

Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Pathology News and Research

Further Reading

Mass spectrometry-based tool successfully used in brain cancer surgery

Loss of p62 protein in cells and tissue surrounding a tumor can influence tumor growth

Galderma's trifarotene molecule gets FDA Orphan Drug Designation for treatment of congenital ichthyosis

Researchers receive over $1M to study molecular foundations of pancreatic cancer

Focal choroidal excavation’s coexistence with other choroidal diseases impairs vision

Researchers identify new protein as possible therapeutic target for pancreatic cancer

Synthetic Biologics supports SYN-004 C.difficile preventative program with formation of Clinical Advisory Board

Outpatient hysteroscopy before IVF doesn't seem to improve IVF results

EMA CHMP recommends marketing authorization for GE's VIZAMYL for PET imaging to detect beta amyloids

Non-Hodgkin lymphoma subgroups found to have different survival rates

Administering low doses of thyroid hormone to rats with diabetes prevents deterioration of heart function

Combination of MRI and PET imaging techniques can prevent second breast biopsy

Frederic Bushman gets Pioneer Award from Human Gene Therapy

BioLineRx announces in-licensing of BL-1110 compound for treatment of neuropathic pain

Definiens closes €15M financing round to expand into digital tissue diagnostics

National, state air pollution controls decrease death rates in North Carolina

Chinese FDA accepts Lee's IND for Phase 2 dry eye study

Yap1 oncogene drives recurrence and progression of pancreatic cancer

Schizophrenia focus narrowed to dentate gyrus

Single dose restores normal cellular signaling in mouse model of autism

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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