Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

EGCG in green tea controls generation of metal-associated amyloids associated with Alzheimer's

Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.

6 Mar 2013

Idera announces new data from IMO-3100 and IMO-8400 preclinical study on psoriasis

Idera Pharmaceuticals, Inc. today announced the presentation of new data showing that its selective Toll-like receptor antagonists, IMO-3100 and IMO-8400, normalized the gene expression of important cytokines in a preclinical study of skin inflammation that is commonly used as a model of psoriasis.

4 Mar 2013

Positive results from NeuroDerm ND0612 Phase I trial on Parkinson's

NeuroDerm, Ltd. announced today the results of a Phase I safety and pharmacokinetic trial of ND0612, a novel drug formulation for the treatment of Parkinson's disease.

4 Mar 2013

Oxford researcher wins 2013 John Dystel Prize from AAN, National Multiple Sclerosis Society

The American Academy of Neurology and the National Multiple Sclerosis Society are awarding the 2013 John Dystel Prize for MS Research to George C. Ebers, MD, a leading researcher with the University of Oxford and Oxford University Hospitals Trust in Oxford, United Kingdom.

2 Mar 2013

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death.

2 Mar 2013

AAN to award 2013 Michael S. Pessin Stroke Leadership Prize to Amytis Towfighi

The American Academy of Neurology is awarding the 2013 Michael S. Pessin Stroke Leadership Prize to Amytis Towfighi, MD, with the University of Southern California and Rancho Los Amigos National Rehabilitation Center for her research in post-stroke preventive care.

2 Mar 2013

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

Researchers at the University of Florida and The Johns Hopkins University have developed a line of genetically altered mice that model the earliest stages of Alzheimer's disease. This model may help scientists identify new therapies to provide relief to patients who are beginning to experience symptoms.

1 Mar 2013

Amyloid plaques take about 15 years to build up and then plateau: Study

Researchers have identified a possible treatment window of several years for plaques in the brain that are thought to cause memory loss in diseases such as Alzheimer's. The Mayo Clinic study is published in the Feb. 27 online issue of Neurology, the medical journal of the American Academy of Neurology.

28 Feb 2013

Researchers to discuss health issues at Society of Toxicology's Annual Meeting and ToxExpo

Researchers will meet at the Society of Toxicology's Annual Meeting and ToxExpo March 10-16 to discuss a number of health concerns that have received growing public attention over the past several months.

27 Feb 2013

Researchers discover novel way to image the entire brain's glymphatic pathway

A novel way to image the entire brain's glymphatic pathway, a dynamic process that clears waste and solutes from the brain that otherwise might build-up and contribute to the development of Alzheimer's disease, may provide the basis for a new strategy to evaluate disease susceptibility, according to a research paper published online in The Journal of Clinical Investigation.

26 Feb 2013

WUSTL to develop 3-D computer models of brain biomechanics to better understand TBI

Washington University in St. Louis engineering researchers have received a five-year, $2.25 million grant to better understand traumatic brain injuries in efforts to improve methods for prevention and treatment.

25 Feb 2013

Researchers identify several genes associated with human neurological disorders

Scientists at the Marine Biological Laboratory (MBL) have identified several genes linked to human neurological disorders, including Alzheimer's disease, Parkinson's disease and spinal cord injury, in the sea lamprey, a vertebrate fish whose whole-genome sequence is reported this week in the journal Nature Genetics.

25 Feb 2013

Targeting CSF1R with selective inhibitors could help Alzheimer's

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases.

22 Feb 2013

Researchers use familial and sporadic patient-derived iPSCs to model Alzheimer's disease

Working with a group from Nagasaki University, a research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has announced in the Feb. 21 online publication of Cell Stem Cell has successfully modeled Alzheimer's disease (AD) using both familial and sporadic patient-derived induced pluripotent stem cells (iPSCs), and revealed stress phenotypes and differential drug responsiveness associated with intracellular amyloid beta oligomers in AD neurons and astrocytes.

21 Feb 2013

Resveratrol may protect against hearing and cognitive decline

Resveratrol, a substance found in red grapes and red wine, may have the potential to protect against hearing and cognitive decline, according to a published laboratory study from Henry Ford Hospital in Detroit.

21 Feb 2013

BCHE gene variant predicts extent of plaque deposits in Alzheimer's

A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer's disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer's -- but has uncovered an association with a second gene, called BCHE.

21 Feb 2013

Dietary antioxidants may not protect against stroke and dementia

Contrary to other research, a new study found that the total level of antioxidants in people's diets is not related to their risk of developing stroke or dementia.

21 Feb 2013

NINDS to award TSRI scientist with $3.5M Jacob K. Javits Neuroscience Investigator Award

Ron Davis, PhD, chair of the Neuroscience Department on the Florida campus of The Scripps Research Institute, has been selected to receive a prestigious $3.5 million Jacob K. Javits Neuroscience Investigator Award for his work on the complex biology of memory formation and the disorders that disrupt it.

21 Feb 2013

Methylene blue inactivates molecular residues that promote bonding of tau proteins

The study published in "Angewandte Chemie" might help to work out strategies for developing potential drugs. As the team of scientist including Markus Zweckstetter and Eckhard Mandelkow report, methylene blue inactivates molecular residues that promote the bonding of tau proteins.

21 Feb 2013

Insight into how NMDA receptors function

In a pair of new papers, researchers at the University of California, San Diego School of Medicine and the Royal Netherlands Academy of Arts and Sciences upend a long-held view about the basic functioning of a key receptor molecule involved in signaling between neurons, and describe how a compound linked to Alzheimer's disease impacts that receptor and weakens synaptic connections between brain cells.

20 Feb 2013

Alzheimer's Disease News and Research

Further Reading

EGCG in green tea controls generation of metal-associated amyloids associated with Alzheimer's

Idera announces new data from IMO-3100 and IMO-8400 preclinical study on psoriasis

Positive results from NeuroDerm ND0612 Phase I trial on Parkinson's

Oxford researcher wins 2013 John Dystel Prize from AAN, National Multiple Sclerosis Society

Researchers identify novel signaling pathway responsible for neuroprotective activity of parkin

AAN to award 2013 Michael S. Pessin Stroke Leadership Prize to Amytis Towfighi

Researchers develop new genetically altered mice that model earliest stages of Alzheimer's

Amyloid plaques take about 15 years to build up and then plateau: Study

Researchers to discuss health issues at Society of Toxicology's Annual Meeting and ToxExpo

Researchers discover novel way to image the entire brain's glymphatic pathway

WUSTL to develop 3-D computer models of brain biomechanics to better understand TBI

Researchers identify several genes associated with human neurological disorders

Targeting CSF1R with selective inhibitors could help Alzheimer's

Researchers use familial and sporadic patient-derived iPSCs to model Alzheimer's disease

Resveratrol may protect against hearing and cognitive decline

BCHE gene variant predicts extent of plaque deposits in Alzheimer's

Dietary antioxidants may not protect against stroke and dementia

NINDS to award TSRI scientist with $3.5M Jacob K. Javits Neuroscience Investigator Award

Methylene blue inactivates molecular residues that promote bonding of tau proteins

Insight into how NMDA receptors function

eBook: Advancing neurodegenerative research with iPSC-derived microglia models eBook

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